Match!
Steven A. Goldman
University of Rochester Medical Center
558Publications
92H-index
47.8kCitations
Publications 527
Newest
#1Elizabeth B Juneman (VA: United States Department of Veterans Affairs)
#2Reza ArsanjaniH-Index: 4
Last.Elizabeth Juneman (VA: United States Department of Veterans Affairs)
view all 7 authors...
This study was designed to determine the potential therapeutic effects of a new sodium-hydrogen exchanger (NHE-1) inhibitor in the rat coronary artery ligation model of chronic heart failure. After the induction of acute myocardial infarction, rats were entered into a randomly designed pilot dose study from 0.3 mg/kg, 1.0 mg/kg, and 3.0 mg/kg. Solid state micrometer hemodynamics, echocardiographic, and pressure-volume relationships were measured after 6 weeks of treatment. Treatment with this NH...
Source
Source
Source
Summary The cellular neurobiology of schizophrenia remains poorly understood. We discuss neuroimaging studies, pathological findings, and experimental work supporting the idea that glial cells might contribute to the development of schizophrenia. Experimental studies suggest that abnormalities in the differentiation competence of glial progenitor cells lead to failure in the morphological and functional maturation of oligodendrocytes and astrocytes. We propose that immune activation of microglia...
1 CitationsSource
#1Martha S. Windrem (UR: University of Rochester)H-Index: 22
#2Steven J. SchanzH-Index: 7
Last.Steven A. GoldmanH-Index: 92
view all 7 authors...
Human glial progenitor cells (hGPCs) can completely myelinate the brains of congenitally hypomyelinated shiverer mice, rescuing the phenotype and extending or normalizing the lifespan of these mice. We asked if implanted hGPCs might be similarly able to broadly disperse and remyelinate the diffusely and/or multicentrically-demyelinated adult CNS. In particular, we asked if fetal hGPCs could effectively remyelinate both congenitally hypomyelinated adult axons, and axons acutely demyelinated in ad...
Source
#1Jordan J. Lancaster (UA: University of Arizona)H-Index: 6
#2Pablo Sanchez (UA: University of Arizona)H-Index: 2
Last.Steven A. Goldman (UA: University of Arizona)H-Index: 92
view all 10 authors...
Background To treat chronic heart failure (CHF), we developed a robust, easy to handle bioabsorbable tissue-engineered patch embedded with human neonatal fibroblasts and human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs). This patch was implanted on the epicardial surface of the heart covering the previously infarcted tissue. Methods Sprague-Dawley rats (6-8 weeks old) underwent sham surgery (n = 12) or left coronary artery ligation (n = 45). CHF rats were randomized 3 weeks ...
Source
#1Ikeotunye Royal Chinyere (UA: University of Arizona)H-Index: 1
#2Mathew D. Hutchinson (UA: University of Arizona)H-Index: 35
Last.Elizabeth Juneman (UA: University of Arizona)H-Index: 9
view all 6 authors...
Introduction While radiofrequency ablation has revolutionized the management of tachyarrhythmias, the rate of arrhythmia recurrence is a large drawback. Successful substrate identification is param...
Source
#1Hiroko Nobuta (UCSF: University of California, San Francisco)H-Index: 14
#2Nan Yang (Stanford University)H-Index: 34
Last.Marius Wernig (Stanford University)H-Index: 51
view all 16 authors...
Summary Pelizaeus-Merzbacher disease (PMD) is an X-linked leukodystrophy caused by mutations in Proteolipid Protein 1 (PLP1), encoding a major myelin protein, resulting in profound developmental delay and early lethality. Previous work showed involvement of unfolded protein response (UPR) and endoplasmic reticulum (ER) stress pathways, but poor PLP1 genotype-phenotype associations suggest additional pathogenetic mechanisms. Using induced pluripotent stem cell (iPSC) and gene-correction, we show ...
Source
#2Jen Watson KoevaryH-Index: 1
Last.Steven A. GoldmanH-Index: 92
view all 6 authors...
Source
#1Ike Chinyere (UA: University of Arizona)H-Index: 1
#2Jordan J. Lancaster (UA: University of Arizona)H-Index: 6
Last.Elizabeth Juneman (UA: University of Arizona)H-Index: 9
view all 6 authors...
Source
12345678910