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Raj Mani
University of Southampton
86Publications
10H-index
331Citations
Publications 86
Newest
Published on Mar 4, 2019in bioRxiv
Daniel J Page (University of Southampton), Claire E. Clarkin10
Estimated H-index: 10
(University of Southampton)
+ 3 AuthorsNicholas D. Evans17
Estimated H-index: 17
(University of Southampton)
The retention and sustained activity of therapeutic proteins at delivery sites are goals of regenerative medicine. Vascular endothelial growth factor (VEGF) has significant potential in promoting the growth and regeneration of blood vessels but is intrinsically labile. This is exacerbated by the inflammatory microenvironments at sites requiring regeneration. For VEGF to be efficacious it may require a carrier that stabilises it, protects it from degradation and retains it at a site of interest. ...
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J. Holmes6
Estimated H-index: 6
,
Sandra Schuh4
Estimated H-index: 4
(Augsburg College)
+ 2 AuthorsJulia Welzel21
Estimated H-index: 21
(Augsburg College)
Chronic wounds such as venous leg ulcers invariably heal slowly and recur. In the case of venous leg ulcers, poor healing of chronic wounds is variously attributed to ambulatory hypertension, impaired perfusion and diffusion, presence of chronic inflammation at wound sites, lipodermatosclerosis, and senescence. The aim of this study was to investigate whether a new technique, optical coherence tomography (OCT), which permits imaging of blood capillaries in the peri-wound skin, can provide new in...
1 Citations Source Cite
Published on Jan 1, 2019
Ravi Mani (Brighton and Sussex Medical School), Kittipan Rerkasem19
Estimated H-index: 19
(Chiang Mai University),
Raj Mani10
Estimated H-index: 10
(University of Southampton)
The theme of this book is compression which is a mainstay of treatment for venous leg ulcers. In other parts of this book, there are descriptions of how elasticated garments are used, the evidence of success to heal wounds as well as the shortcomings of this technique that beg questions of how compression may be delivered using other methods. These include surgery to treat incompetence in the superficial veins, advances on traditional bandages and intermittent pneumatic compression (IPC). Initia...
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Published on Jan 1, 2019
Boonying Siribumrungwong10
Estimated H-index: 10
(Thammasat University Hospital),
Saritphat Orrapin2
Estimated H-index: 2
(Thammasat University Hospital)
+ 1 AuthorsKittipan Rerkasem19
Estimated H-index: 19
Venous leg ulcer is an important health problem worldwide in which compression therapy has been recommended as first line standard treatment. However, some patients fail after compression therapy or have poor compliance with it. In this chapter, we discussed about other alternative treatments especially surgical therapy along with theirs evidence-based recommendations according to pathophysiology of venous leg ulcer.
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Published on Jan 1, 2019
Hugo Partsch15
Estimated H-index: 15
(Medical University of Vienna),
Raj Mani10
Estimated H-index: 10
(University of Southampton)
Compression is the mainstay of management of ambulatory venous hypertension, the most common sequel of which is venous leg ulceration. The logic for selecting compression is based on physical principles governing tension, pressure, volume as elegantly enshrined in the works of French mathematician philosophers Laplace and prior to him, Pascal. The application of Laplace’s law for using compression bandages to manage limb swelling consequent to unrelieved venous pressures and sequelae are describ...
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Published on Jan 1, 2019
Naseer Ahmad (University of Manchester), Frank Lee Bowling (University of Manchester), Raj Mani10
Estimated H-index: 10
(University of Southampton)
The burden of chronic wounds is rising and therefore significant on both individuals and society. Whilst the mainstay of leg ulcer care is compression, the provision of this service is actually sporadic. This inequity is partly responsible for varying outcomes of care. In order to improve outcomes, a detailed understanding of the patient journey through a ‘whole systems analysis’ is required. Here, a detailed analysis of the processes and organisations the patient comes into contact with are und...
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Raj Mani10
Estimated H-index: 10
(University of Southampton)
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Massimo Papi1
Estimated H-index: 1
,
Kittipan Rerkasem19
Estimated H-index: 19
(Chiang Mai University),
Raj Mani10
Estimated H-index: 10
(University of Southampton)
1 Citations Source Cite
Kittipan Rerkasem19
Estimated H-index: 19
(Chiang Mai University),
Massimo Papi1
Estimated H-index: 1
,
Raj Mani10
Estimated H-index: 10
(University of Southampton)
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Kittipan Rerkasem19
Estimated H-index: 19
(Chiang Mai University),
Massimo Papi1
Estimated H-index: 1
,
Raj Mani10
Estimated H-index: 10
(University of Southampton)
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