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Tsutomu Wada
University of Toyama
73Publications
28H-index
2,078Citations
Publications 73
Newest
#1Kanta KonH-Index: 3
#2Hiroshi TsunekiH-Index: 28
Last.Toshiyasu SasaokaH-Index: 35
view all 12 authors...
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#1Tsutomu Wada (University of Toyama)H-Index: 28
#2Hiroshi Tsuneki (University of Toyama)H-Index: 28
Last.Toshiyasu Sasaoka (University of Toyama)H-Index: 35
view all 3 authors...
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#1Tsutomu WadaH-Index: 28
#2Yasuhiro OnogiH-Index: 3
Last.Toshiyasu SasaokaH-Index: 35
view all 8 authors...
White adipose tissue (WAT) expands with angiogenesis. We have demonstrated that adipose-tissue-macrophages (ATMs) highly express platelet-derived growth factor (PDGF)-B in obesity, and exposure of PDGF-B stimulates detachment of pericytes (PCs) from vessels. Since vessel-attached PCs inhibit endothelial cell growth, the detachment restarts angiogenesis. In the present study, we aimed to clarify the significance of ATMs on adipose angiogenesis. Intraperitoneal injection of liposome-encapsulated c...
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#1Hiroshi Tsuneki (University of Toyama)H-Index: 28
#2Hitomi Yoshida (University of Toyama)H-Index: 1
Last.Toshiyasu Sasaoka (University of Toyama)H-Index: 35
view all 10 authors...
Abstract Brain-derived neurotrophic factor (BDNF), an essential factor for maintaining brain functions, has been reported to be reduced in various neurological diseases, including Alzheimer's disease and major depression. Therefore, new drugs to increase the BDNF expression need to be developed. Since phosphatidylinositol (3,4,5)-trisphosphate, a membrane signaling molecule produced by phosphoinositide 3 (PI3)-kinase in the BDNF signaling, is a candidate target of SH2 domain-containing inositol ...
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#1Tsutomu Wada (University of Toyama)H-Index: 28
#2Azusa Sameshima (University of Toyama)H-Index: 3
Last.Shigeru Saito (University of Toyama)H-Index: 70
view all 8 authors...
Obesity and diabetes increase the risk of depression, and the incidence of these conditions increases rapidly after menopause, but few animal models of postmenopausal obesity have been available. We developed a mouse model of postmenopausal obesity that exhibited anxiety and depressive phenotypes in behavioral tests. To examine the effect of estradiol (E2) in the model, we prepared 4 experimental groups: 1) control, sham-operated female C57BL/6 mice fed a regular diet; 2) OVX-HF, ovariectomized ...
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#1Kanta KonH-Index: 3
#2Hiroshi TsunekiH-Index: 28
Last.Toshiyasu SasaokaH-Index: 35
view all 6 authors...
Decreased estrogen is a crucial pathogenic factor for type 2 diabetes in postmenopausal women; however, the precise mechanism remains unknown. Orexin is a major hypothalamic neuropeptides regulating energy/glucose metabolism, and its anti-obese effect is more evident in females. We therefore investigated whether estrogen prevents obesity and glucose intolerance through interaction with the orexin system. Ovariectomized (OVX) mice and female orexin knockout (OXKO) mice were prepared to examine th...
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#1Tsutomu WadaH-Index: 28
#2Eri WatanabeH-Index: 1
Last.Toshiyasu SasaokaH-Index: 35
view all 6 authors...
Adipose tissue (AT) expands with angiogenesis in obesity. Mature vessels in the epididymal white adipose tissue (eWAT) are tightly wrapped with pericytes (PCs), which attenuates endothelial (ECs) proliferation. We found that obesity-associated increase of PDGF-B promoted detachment of PCs from nature vessels; thereby vessels were prone to neoangiogenesis. In this study, we aimed to clarify the role of stromal cell derived factor 1 (SDF1), another proangiogenic factor in the AT development in obe...
Source
#1Yasuhiro OnogiH-Index: 3
#2Tsutomu WadaH-Index: 28
Last.Toshiyasu SasaokaH-Index: 35
view all 7 authors...
The vascular network develops with remodeling in adipose tissue (AT) during obesity. We have found that PDGF-B detaches pericytes from the vasculature, which plays a crucial role in angiogenesis during obesity. The expression of PDGF-B was significantly elevated in obesity-associated infiltrated CD11c-positive (+) AT macrophages (ATMs). Interestingly, the expression was low in both CD11c + ATMs and CD206 + ATMs of lean mice. Since glycolytic and oxidative metabolism are key metabolic programs th...
Source
#1Hiroshi Tsuneki (University of Toyama)H-Index: 28
#2Tsutomu Wada (University of Toyama)H-Index: 28
Last.Toshiyasu Sasaoka (University of Toyama)H-Index: 35
view all 3 authors...
Abstract Sleep, a mysterious behavior, has recently been recognized as a crucial factor for health and longevity. The daily sleep/wake cycle provides the basis of biorhythms controlling whole-body homeostasis and homeodynamics; therefore, disruption of sleep causes several physical and psychological disorders, including cardiovascular disease, obesity, diabetes, cancer, anxiety, depression, and cognitive dysfunction. However, the mechanism linking sleep disturbances and sleep-related disorders r...
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