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George M Church G M
765Publications
135H-index
70.6kCitations
Publications 765
Newest
Published on Mar 27, 2019in BMC Medicine 9.09
Tim K. Mackey21
Estimated H-index: 21
,
Tsung-Ting Kuo12
Estimated H-index: 12
(University of California, San Diego)
+ 6 AuthorsMaria Palombini1
Estimated H-index: 1
Blockchain is a shared distributed digital ledger technology that can better facilitate data management, provenance and security, and has the potential to transform healthcare. Importantly, blockchain represents a data architecture, whose application goes far beyond Bitcoin – the cryptocurrency that relies on blockchain and has popularized the technology. In the health sector, blockchain is being aggressively explored by various stakeholders to optimize business processes, lower costs, improve p...
1 Citations Source Cite
Published on Feb 27, 2019in Genome Medicine 8.90
Emilie S. Zoltick4
Estimated H-index: 4
(Boston University),
Michael D. Linderman21
Estimated H-index: 21
(Icahn School of Medicine at Mount Sinai)
+ 12 AuthorsC. Thomas Caskey45
Estimated H-index: 45
(Baylor College of Medicine)
Background Increasing numbers of healthy individuals are undergoing predispositional personal genome sequencing. Here we describe the design and early outcomes of the PeopleSeq Consortium, a multi-cohort collaboration of predispositional genome sequencing projects, which is examining the medical, behavioral, and economic outcomes of returning genomic sequencing information to healthy individuals.
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Published on Jun 9, 2019in bioRxiv
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Published on May 16, 2019
Eric D. Kelsic6
Estimated H-index: 6
,
George M Church G M135
Estimated H-index: 135
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Published on May 12, 2019in bioRxiv
Namita Bhan11
Estimated H-index: 11
(Northwestern University),
Jonathan Strutz1
Estimated H-index: 1
(Northwestern University)
+ 5 AuthorsKeith Edward Jaggard Tyo20
Estimated H-index: 20
(Northwestern University)
Recording biological signals can be difficult in three-dimensional matrices, such as tissue. We present a DNA polymerase-based strategy that records temporal biosignals locally into DNA to be read out later, which could obviate the need to extract information from tissue on the fly. We use a template-independent DNA polymerase, terminal deoxynucleotidyl transferase (TdT) that probabilistically adds dNTPs to single-stranded DNA (ssDNA) substrates without a template. We show that in vitro, the dNT...
1 Citations Source Cite
Published on May 1, 2019in Genome Research 10.10
Kornel Labun2
Estimated H-index: 2
(University of Bergen),
Xiaoge Guo1
Estimated H-index: 1
(Wyss Institute for Biologically Inspired Engineering)
+ 3 AuthorsEivind Valen27
Estimated H-index: 27
(University of Bergen)
We present ampliCan, an analysis tool that unites identification, quantification and visualization of genuine genome editing events from CRISPR amplicon sequencing data. ampliCan overcomes methodological challenges suffered by other tools to estimate the true mutational efficiency in a high-throughput automated fashion. ampliCan controls for biases at every step of the analysis and generates reports that allow users to quickly identify successful editing events or potential issues with their exp...
2 Citations Source Cite
Charleston Noble5
Estimated H-index: 5
(Harvard University),
John Min5
Estimated H-index: 5
(Massachusetts Institute of Technology)
+ 7 AuthorsKevin M. Esvelt16
Estimated H-index: 16
(Massachusetts Institute of Technology)
If they are able to spread in wild populations, CRISPR-based gene-drive elements would provide new ways to address ecological problems by altering the traits of wild organisms, but the potential for uncontrolled spread tremendously complicates ethical development and use. Here, we detail a self-exhausting form of CRISPR-based drive system comprising genetic elements arranged in a daisy chain such that each drives the next. “Daisy-drive” systems can locally duplicate any effect achievable by usin...
32 Citations Source Cite
Published on Apr 8, 2019in Nature microbiology 14.17
Henry H. Lee5
Estimated H-index: 5
(Harvard University),
Nili Ostrov5
Estimated H-index: 5
(Harvard University)
+ 3 AuthorsGeorge M Church G M135
Estimated H-index: 135
(Wyss Institute for Biologically Inspired Engineering)
The fast-growing Gram-negative bacterium Vibrio natriegens is an attractive microbial system for molecular biology and biotechnology due to its remarkably short generation time1,2 and metabolic prowess3,4. However, efforts to uncover and utilize the mechanisms underlying its rapid growth are hampered by the scarcity of functional genomic data. Here, we develop a pooled genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) interference (CRISPRi) screen to identify a minim...
1 Citations Source Cite
Published on Apr 8, 2019in Nucleic Acids Research 11.56
Margret R. Hoehe34
Estimated H-index: 34
(Max Planck Society),
Ralf Herwig42
Estimated H-index: 42
(Max Planck Society)
+ 4 AuthorsThomas Huebsch4
Estimated H-index: 4
(Max Planck Society)
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