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Riffat Ahmed
Oregon National Primate Research Center
14Publications
10H-index
870Citations
Publications 14
Newest
Published on Mar 1, 2019in Nature43.07
Eunju Kang13
Estimated H-index: 13
(Oregon National Primate Research Center),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
Published on Sep 11, 2018
Hong Ma27
Estimated H-index: 27
,
Nuria Marti-Gutierrez1
Estimated H-index: 1
+ 27 AuthorsRiffat Ahmed10
Estimated H-index: 10
Published on Jul 24, 2018in PLOS ONE2.78
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Yeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
+ 12 AuthorsHayley Darby1
Estimated H-index: 1
(Oregon National Primate Research Center)
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2–34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve...
Published on Aug 1, 2017in Nature43.07
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(OHSU: Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(OHSU: Oregon Health & Science University)
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
Published on Jan 1, 2017in Cell Stem Cell21.46
Hong Ma27
Estimated H-index: 27
(OHSU: Oregon Health & Science University),
Ryan C. O’Neil4
Estimated H-index: 4
(UCSD: University of California, San Diego)
+ 23 AuthorsYeonmi Lee6
Estimated H-index: 6
(OHSU: Oregon Health & Science University)
Summary Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT). The reconstructed oocytes supported the formation of de novo meiotic spindles and, after fertilization with sperm, meiosis completion and ...
Published on Dec 1, 2016in Nature43.07
Eunju Kang13
Estimated H-index: 13
(UOU: University of Ulsan),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(OHSU: Oregon Health & Science University)
Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.
Published on May 1, 2016in Cell Stem Cell21.46
Eunju Kang13
Estimated H-index: 13
(Oregon National Primate Research Center),
Xinjian Wang20
Estimated H-index: 20
(Cincinnati Children's Hospital Medical Center)
+ 20 AuthorsYing Li14
Estimated H-index: 14
(Oregon National Primate Research Center)
Summary The genetic integrity of iPSCs is an important consideration for therapeutic application. In this study, we examine the accumulation of somatic mitochondrial genome (mtDNA) mutations in skin fibroblasts, blood, and iPSCs derived from young and elderly subjects (24–72 years). We found that pooled skin and blood mtDNA contained low heteroplasmic point mutations, but a panel of ten individual iPSC lines from each tissue or clonally expanded fibroblasts carried an elevated load of heteroplas...
Published on Sep 1, 2015in Mitochondrion3.45
Amy Koski5
Estimated H-index: 5
(OHSU: Oregon Health & Science University),
Hong Ma27
Estimated H-index: 27
(OHSU: Oregon Health & Science University)
+ 23 AuthorsXinjian Wang20
Estimated H-index: 20
(Cincinnati Children's Hospital Medical Center)
Published on Aug 1, 2015in Nature43.07
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Clifford D.L. Folmes17
Estimated H-index: 17
(Mayo Clinic)
+ 23 AuthorsRiffat Ahmed10
Estimated H-index: 10
(OHSU: Oregon Health & Science University)
Mitochondria have a major role in energy production via oxidative phosphorylation, which is dependent on the expression of critical genes encoded by mitochondrial (mt)DNA. Mutations in mtDNA can cause fatal or severely debilitating disorders with limited treatment options. Clinical manifestations vary based on mutation type and heteroplasmy (that is, the relative levels of mutant and wild-type mtDNA within each cell). Here we generated genetically corrected pluripotent stem cells (PSCs) from pat...
Published on Jul 1, 2014in Nature43.07
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Robert Morey9
Estimated H-index: 9
(UCSD: University of California, San Diego)
+ 23 AuthorsKaren Sabatini6
Estimated H-index: 6
(UCSD: University of California, San Diego)
Genome-wide analysis of matched human IVF embryonic stem cells (IVF ES cells), induced pluripotent stem cells (iPS cells) and nuclear transfer ES cells (NT ES cells) derived by somatic cell nuclear transfer (SCNT) reveals that human somatic cells can be faithfully reprogrammed to pluripotency by SCNT; NT ES cells and iPS cells derived from the same somatic cells contain comparable numbers of de novo copy number variations, but whereas DNA methylation and transcriptome profiles of NT ES cells and...
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