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Chow H. Lee
University of Northern British Columbia
Messenger RNAMolecular biologyBiochemistryRNABiology
21Publications
9H-index
312Citations
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Publications 22
Newest
#1Almas Yaqoob (UNBC: University of Northern British Columbia)H-Index: 1
#2Wai Ming Li (UNBC: University of Northern British Columbia)H-Index: 2
Last. Chow H. Lee (UNBC: University of Northern British Columbia)H-Index: 9
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In our search for bioactive mushrooms native to British Columbia, we determined that the ethanol extracts from fruiting bodies of the terrestrial polypore Albatrellus flettii had potent anti-cell viability activity. Using bioassay-guided fractionation, mass spectrometry and nuclear magnetic resonance, we successfully isolated three known compounds (grifolin, neogrifolin and confluentin). These compounds represent the major anti-cell viability components from the ethanol extracts of A. flettii. W...
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#1Sumreen JavedH-Index: 1
#2Wai Ming LiH-Index: 2
Last. Chow H. LeeH-Index: 9
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The aim of this study was to investigate the anti-inflammatory activity of a previously un-studied wild mushroom, Echinodontium tinctorium, collected from the forests of north-central British Columbia. The lipopolysaccharide (LPS)-induced RAW264.7 macrophage model was used to study the in vitro anti-inflammatory activity. The crude alkaline extract demonstrated potent anti-inflammatory activity, and was further purified using a “bio-activity-guided-purification” approach. The size-exclusion and ...
1 CitationsSource
#1Sumreen JavedH-Index: 1
#2Kevin J. MitchellH-Index: 29
Last. Geoffrey W. PayneH-Index: 11
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2 CitationsSource
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#1Sebastian Mackedenski (UNBC: University of Northern British Columbia)H-Index: 4
#2Chuyi Wang (UNBC: University of Northern British Columbia)H-Index: 1
Last. Chow H. Lee (UNBC: University of Northern British Columbia)H-Index: 9
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Insulin-like growth factor 2 mRNA-binding protein-1 (IMP1) has high affinity for KRAS mRNA, and it can regulate KRAS expression in cells. We first characterized the molecular interaction between IMP1 and KRAS mRNA. Using IMP1 variants with a point mutation in the GXXG motif at each KH domain, we showed that all KH domains play a critical role in the binding of KRAS RNA. We mapped the IMP1-binding sites on KRAS mRNA and show that IMP1 has the highest affinity for nts 1–185. Although it has lower ...
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#1Ankush Barad (UNBC: University of Northern British Columbia)H-Index: 2
#2Sebastian Mackedenski (UNBC: University of Northern British Columbia)H-Index: 4
Last. Chow H. Lee (UNBC: University of Northern British Columbia)H-Index: 9
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• Polysaccharide (GIPinv) with anti-cancer activity was purified from Paxillus involutus .
4 CitationsSource
Last. Chow H. LeeH-Index: 9
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2 CitationsSource
Last. Chow H. LeeH-Index: 9
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#1Kashif Mehmood (UNBC: University of Northern British Columbia)H-Index: 2
#2Daud Akhtar (UNBC: University of Northern British Columbia)H-Index: 1
Last. Chow H. Lee (UNBC: University of Northern British Columbia)H-Index: 9
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The stabilization of glioma-associated oncogene 1 (GLI1) mRNA by coding region determinant binding protein (CRD-BP) through the Wnt/ β -catenin signaling pathway is implicated in the proliferation of colorectal cancer and basal cell carcinoma. Here, we set out to characterize the physical interaction between CRD-BP and GLI1 mRNA so as to find inhibitors for such interaction. Studies using CRD-BP variants with a point mutation in the GXXG motif at each KH domain showed that KH1 and KH2 domain are...
4 CitationsSource
#1Sebastian Mackedenski (UNBC: University of Northern British Columbia)H-Index: 4
#2Chow H. Lee (UNBC: University of Northern British Columbia)H-Index: 9
The Coding Region Determinant-Binding Protein (CRD-BP) is an RNA-binding protein which, among other functions, provides a protective effect for select target mRNA transcripts against degradation, effectively increasing their half-life leading to elevated level of gene expression. CRD-BP was first identified due to its inherent ability to bind to a specific coding region of c-myc mRNA. It has further been demonstrated to convey a protective effect to target transcripts, including GLI1, MITF, CD44...
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