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Paola Venditti
University of Naples Federico II
85Publications
26H-index
2,460Citations
Publications 85
Newest
From their discovery in biological systems, reactive oxygen species (ROS) have been considered key players in tissue injury for their capacity to oxidize biological macromolecules [...]
Unaccustomed and/or exhaustive exercise generates excessive free radicals and reactive oxygen and nitrogen species leading to muscle oxidative stress-related damage and impaired contractility. Conversely, a moderate level of free radicals induces the body’s adaptive responses. Thus, a low oxidant level in resting muscle is essential for normal force production, and the production of oxidants during each session of physical training increases the body’s antioxidant defenses. Mitochondria, NADPH o...
Abstract The cholesterol metabolite 24(S)-hydroxycholesterol (24S-OHC) allows cholesterol excretion from the brain and was suggested to be critically involved in physiological as well as neurodegenerative processes. It induces on human neuronal cell cultures a dose dependent toxicity associated with increased reactive oxygen species production. Since glial cells play a key role in assisting neuronal function, here we investigated the effects of increased concentrations of 24S-OHC on a glial cell...
#1Paola VendittiH-Index: 26
#2Tanea T. Reed (EKU: Eastern Kentucky University)H-Index: 7
Last.Sergio Di MeoH-Index: 14
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AbstractIn addition to insulin, glycemic control involves thyroid hormones. However, an excess of thyroid hormone can disturb the blood glucose equilibrium, leading to alterations of carbohydrate metabolism and, eventually, diabetes. Indeed, experimental and clinical hyperthyroidism is often accompanied by abnormal glucose tolerance. A common characteristic of hyperthyroidism and type 2 diabetes is the altered mitochondrial efficiency caused by the enhanced production of reactive oxygen and nitr...
#1Gaetana Napolitano (University of Naples Federico II)H-Index: 7
#2Paola Venditti (University of Naples Federico II)H-Index: 26
Last.Claudio Agnisola (University of Naples Federico II)H-Index: 16
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Rapid fluctuations of the oxygen content of both natural and anthropogenic origin are relatively common in freshwater environments. Fish adaptation to these conditions implies tolerance of both low levels of oxygen availability and reoxygenation. Hypoxia tolerance in fish has been widely studied, but the involvement of mitochondria in the response of fish to rapid hypoxia/reoxygenation stress is less known. Zebrafish, a floodplain species, is likely facing significant changes in dissolved oxygen...
Abstract We investigated the effects of thyroid state on the mechanisms underlying rat heart mitochondrial capacity to remove H 2 O 2 produced by an exogenous source. The removal rates were higher in the presence of respiratory substrates independently from thyroid state and were higher in hyperthyroid than in hypothyroid preparations. The thyroid state-linked changes in H 2 O 2 removal rates, mirrored those in H 2 O 2 release rates, showing that endogenous and exogenous H 2 O 2 do not compete f...
#1Gaetana Napolitano (University of Naples Federico II)H-Index: 7
#2Daniela Barone (University of Naples Federico II)H-Index: 5
Last.Paola Venditti (University of Naples Federico II)H-Index: 26
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We studied the effects of adrenaline administration and depletion (induced by reserpine) on rat liver oxidative metabolism. We showed that adrenaline increases, and reserpine decreases aerobic capacity (inferred by cytochrome oxidase activity) in tissue modifying the hepatic content of mitochondrial proteins without changing mitochondrial aerobic capacity. The changes in tissue cytochrome oxidase activity, which agreed with the expression levels of factors involved in mitochondrial biogenesis, s...
#1Sergio Di MeoH-Index: 14
#2Tanea T. Reed (EKU: Eastern Kentucky University)H-Index: 7
Last.Victor M. Victor (University of Valencia)H-Index: 37
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#1Paola VendittiH-Index: 26
#2Yong Zhang (Tianjin University of Sport)H-Index: 12
Last.José Magalhães (University of Porto)H-Index: 27
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