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Ashraf Shamaa
Cairo University
27Publications
4H-index
145Citations
Publications 27
Newest
Published on May 1, 2019in Research in Veterinary Science 1.75
Ahmed N. Abdallah1
Estimated H-index: 1
,
Ashraf Shamaa4
Estimated H-index: 4
,
Omar S. El-Tookhy3
Estimated H-index: 3
Abstract Multiple sclerosis (MS) is a progressive demyelinating disease of the central nervous system that destroys oligodendrocytes. This work aims to evaluate the treatment of experimentally induced MS in dogs using laser activated non-expanded adipose derived stem cells. The results showed amelioration of the clinical signs over time confirmed by the resolution of the previous lesions on MRI. Positive migration of the injected cells to the site of lesion, increased remyelination detected by M...
Published on Apr 1, 2019in Biomedicine & Pharmacotherapy 3.74
Maha Abdelmonem1
Estimated H-index: 1
(Cairo University),
Nancy N. Shahin6
Estimated H-index: 6
(Cairo University)
+ 3 AuthorsAmira A. Shaheen10
Estimated H-index: 10
(Cairo University)
Abstract Stem cell therapy represents a promising therapeutic avenue for cardiac disorders, including heart failure. Although stem cell transplantation showed encouraging preliminary results, the outcomes of clinical studies are still unsatisfactory. This study aimed to compare the outcomes of two therapeutic approaches, in vivo co-delivery of sodium hydrogen sulfide (NaHS) concomitant with bone marrow-derived mesenchymal stem cell (BMSC) transplantation and in vitro preconditioning of BMSCs wit...
Published on Dec 1, 2018in Canadian Journal of Physiology and Pharmacology 2.04
Manal Moustafa Mahmoud2
Estimated H-index: 2
(Cairo University),
Asmaa Mohammed Shamseldeen (Cairo University)+ 3 AuthorsDoaa M. Gharib2
Estimated H-index: 2
(Cairo University)
Volume overload is a common phenomenon in patients with chronic kidney disease that is associated with cardiovascular risk factors. However, its contribution to the development of adverse cardiovascular outcomes in those patients is not fully understood. Thus, the present work investigated the effect of salt-induced volume overload on cardiac functions and geometry in a rat model of chronic kidney disease. Thirty adult male Sprague–Dawley rats were randomly divided. One set of animals received a...
Published on Dec 1, 2018in Scientific Reports 4.01
Sekaran Saravanan2
Estimated H-index: 2
(UM: University of Manitoba),
Niketa Sareen3
Estimated H-index: 3
(UM: University of Manitoba)
+ 9 AuthorsMeenal Moudgil2
Estimated H-index: 2
(UM: University of Manitoba)
Abnormal conduction and improper electrical impulse propagation are common in heart after myocardial infarction (MI). The scar tissue is non-conductive therefore the electrical communication between adjacent cardiomyocytes is disrupted. In the current study, we synthesized and characterized a conductive biodegradable scaffold by incorporating graphene oxide gold nanosheets (GO-Au) into a clinically approved natural polymer chitosan (CS). Inclusion of GO-Au nanosheets in CS scaffold displayed two...
Published on Jun 1, 2018in Journal of Musculoskeletal Research
Dina Sabry19
Estimated H-index: 19
(Cairo University),
Ashraf Shamaa4
Estimated H-index: 4
(Cairo University)
+ 5 AuthorsAzza Elamir1
Estimated H-index: 1
(FU: Fayoum University)
Mesenchymal stem cells (MSCs) releases in culture extracellular vesicles called microvesicles (MVs). MVs have beneficial cytokines that prevent progression of the disease and help in the regeneration process. This study is aimed to evaluate the effect of MSCs derived MVs in repair of induced chondral defect in a dog model. Methods: Chondral defects were created surgically (3mm×1mm) in both femoral condyles of nine dogs, autologous MSCs were isolated and MVs were prepared and injected intraarticu...
Published on Jan 1, 2018in Biomedical Research-tokyo 1.22
Dina Sabry19
Estimated H-index: 19
,
Abeer Mostafa3
Estimated H-index: 3
+ 6 AuthorsWarda A. Khalifa
Background: Intrauterine adhesions (IUA) remain a major cause of infertility. The prevalence of IUA varies geographically and keeps increasing over the last few decades due to increased hysteroscopic surgeries. Therefore, IUA management has received considerable attention. However, the management of IUAs still presents a big challenge: the recurrence rate could be up to 62.5% in severe IUAs. Intrauterine adhesion (IUA) occurs as a result of endometrial destruction by surgical interventions or in...
Published on Jan 1, 2018
Nesrine Ebrahim3
Estimated H-index: 3
(Banha University),
Mohamed Salem5
Estimated H-index: 5
(Banha University)
+ 1 AuthorsAshraf Shamaa4
Estimated H-index: 4
(Cairo University)
Background Hypoxic-ischemic encephalopathy (HIE) in neonates is a serious disorder, and till now, no curable treatment is available. Aim The present study was conducted to evaluate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) in attenuating the experimentally induced brain HIE in neonatal rats. Materials and methods Totally, 45 healthy neonatal rats (7 days old) were divided into three groups: group I was the control group. In group II (encephalopathy group), ra...
Published on Nov 30, 2017in International journal of stem cells
Omar S. El-Tookhy3
Estimated H-index: 3
(Cairo University),
Ashraf Shamaa4
Estimated H-index: 4
(Cairo University)
+ 2 AuthorsOmnia M. Azzam1
Estimated H-index: 1
The present study investigated whether MSCs derived microvesicles (MVs) or (Exosomes) can exert therapeutic effects on an experimental model of cutaneous injury and explored the underlying involving mechanisms.Three bilateral full thickness circular wounds were created on the back of two groups of dogs using 2-cm dermal punch. The wounds were at least 2.5 cm apart. Saline was subcutaneously injected in 4 places around each wound area in group-I (control), whereas an equal volume of exosomal solu...
Published on Oct 31, 2017in Bioscience Reports 2.54
Dina Sabry19
Estimated H-index: 19
(Cairo University),
Abeer Mostafa3
Estimated H-index: 3
(Cairo University)
+ 4 AuthorsAshraf Shamaa4
Estimated H-index: 4
(Cairo University)
Endometrial fibrosis is the presence of intrauterine adhesions (IUAs) after any uterine surgery or curettage and it results in infertility and recurrent pregnancy loss. We evaluated the role of human mesenchymal stem cells (hMSCs) as a therapeutic agent of endometrial fibrosis. We also compared the effect of MSCs with the effect of estrogen and neupogen either each alone or as a combined therapy with MSCs. This experimental study was performed on 84 albino rats which were divided into seven grou...
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