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Ashraf Shamaa
Cairo University
28Publications
5H-index
172Citations
Publications 28
Newest
#1Ahmed N. AbdallahH-Index: 2
#2Ashraf Shamaa (Cairo University)H-Index: 5
Last.Omar El-Tookhy (Cairo University)H-Index: 3
view all 3 authors...
Abstract Multiple sclerosis (MS) is a progressive demyelinating disease of the central nervous system that destroys oligodendrocytes. This work aims to evaluate the treatment of experimentally induced MS in dogs using laser activated non-expanded adipose derived stem cells. The results showed amelioration of the clinical signs over time confirmed by the resolution of the previous lesions on MRI. Positive migration of the injected cells to the site of lesion, increased remyelination detected by M...
1 CitationsSource
#1Maha Abdelmonem (Cairo University)H-Index: 1
#2Nancy N. Shahin (Cairo University)H-Index: 6
Last.Amira A. Shaheen (Cairo University)H-Index: 10
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Abstract Stem cell therapy represents a promising therapeutic avenue for cardiac disorders, including heart failure. Although stem cell transplantation showed encouraging preliminary results, the outcomes of clinical studies are still unsatisfactory. This study aimed to compare the outcomes of two therapeutic approaches, in vivo co-delivery of sodium hydrogen sulfide (NaHS) concomitant with bone marrow-derived mesenchymal stem cell (BMSC) transplantation and in vitro preconditioning of BMSCs wit...
1 CitationsSource
#1Nesrine EbrahimH-Index: 3
Last.Ashraf ShamaaH-Index: 5
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Source
#1Manal M. Mahmoud (Cairo University)H-Index: 2
#2Asmaa Mohammed Shamseldeen (Cairo University)H-Index: 1
Last.Doaa M. Gharib (Cairo University)H-Index: 2
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Volume overload is a common phenomenon in patients with chronic kidney disease that is associated with cardiovascular risk factors. However, its contribution to the development of adverse cardiovas...
Source
#1S. Saravanan (UM: University of Manitoba)H-Index: 18
#2Niketa Sareen (UM: University of Manitoba)H-Index: 4
Last.Sanjiv Dhingra (UM: University of Manitoba)H-Index: 18
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Abnormal conduction and improper electrical impulse propagation are common in heart after myocardial infarction (MI). The scar tissue is non-conductive therefore the electrical communication between adjacent cardiomyocytes is disrupted. In the current study, we synthesized and characterized a conductive biodegradable scaffold by incorporating graphene oxide gold nanosheets (GO-Au) into a clinically approved natural polymer chitosan (CS). Inclusion of GO-Au nanosheets in CS scaffold displayed two...
10 CitationsSource
#1Manal M. MahmoudH-Index: 2
Last.Ashraf ShamaaH-Index: 5
view all 4 authors...
Source
#1Dina Sabry (Cairo University)H-Index: 20
#2Ashraf Shamaa (Cairo University)H-Index: 5
Last.Azza Elamir (FU: Fayoum University)H-Index: 2
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Mesenchymal stem cells (MSCs) releases in culture extracellular vesicles called microvesicles (MVs). MVs have beneficial cytokines that prevent progression of the disease and help in the regeneration process. This study is aimed to evaluate the effect of MSCs derived MVs in repair of induced chondral defect in a dog model. Methods: Chondral defects were created surgically (3mm×1mm) in both femoral condyles of nine dogs, autologous MSCs were isolated and MVs were prepared and injected intraarticu...
Source
Background: Intrauterine adhesions (IUA) remain a major cause of infertility. The prevalence of IUA varies geographically and keeps increasing over the last few decades due to increased hysteroscopic surgeries. Therefore, IUA management has received considerable attention. However, the management of IUAs still presents a big challenge: the recurrence rate could be up to 62.5% in severe IUAs. Intrauterine adhesion (IUA) occurs as a result of endometrial destruction by surgical interventions or in...
Source
#1Nesrine Ebrahim (Banha University)H-Index: 3
#2Mohamed Salem (Banha University)H-Index: 2
Last.Ashraf Shamaa (Cairo University)H-Index: 5
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Background Hypoxic-ischemic encephalopathy (HIE) in neonates is a serious disorder, and till now, no curable treatment is available. Aim The present study was conducted to evaluate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) in attenuating the experimentally induced brain HIE in neonatal rats. Materials and methods Totally, 45 healthy neonatal rats (7 days old) were divided into three groups: group I was the control group. In group II (encephalopathy group), ra...
1 CitationsSource
#1Omar El-Tookhy (Cairo University)H-Index: 3
#2Ashraf Shamaa (Cairo University)H-Index: 5
Last.Omnia M. AzzamH-Index: 1
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The present study investigated whether MSCs derived microvesicles (MVs) or (Exosomes) can exert therapeutic effects on an experimental model of cutaneous injury and explored the underlying involving mechanisms.Three bilateral full thickness circular wounds were created on the back of two groups of dogs using 2-cm dermal punch. The wounds were at least 2.5 cm apart. Saline was subcutaneously injected in 4 places around each wound area in group-I (control), whereas an equal volume of exosomal solu...
5 CitationsSource
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