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Erika Kleiderman
McGill University
20Publications
5H-index
116Citations
Publications 20
Newest
Erika Kleiderman5
Estimated H-index: 5
(McGill University),
Ian Stedman (York University)
Human germline genome editing may prove to be especially poignant for members of the rare disease community, many of whom are diagnosed with monogenic diseases. This community lacks broad representation in the literature surrounding genome editing, notably in Canada, yet is likely to be directly affected by eventual clinical applications of this technology. Although not generalizable, the literature does offer some commonalities regarding the experiences of rare disease patients. This manuscript...
Published on Jul 20, 2019in Journal of Medical Ethics2.19
Erika Kleiderman5
Estimated H-index: 5
(McGill University),
Vardit Ravitsky14
Estimated H-index: 14
(UdeM: Université de Montréal),
Bartha Maria Knoppers49
Estimated H-index: 49
(McGill University)
Current advances in assisted reproductive technologies aim to promote the health and well-being of future children. They offer the possibility to select embryos with the greatest potential of being born healthy (eg, preimplantation genetic testing) and may someday correct faulty genes responsible for heritable diseases in the embryo (eg, human germline genome modification (HGGM)). Most laws and policy statements surrounding HGGM refer to the notion of ‘serious’ as a core criterion in determining...
Published on Jul 10, 2019in Frontiers of Medicine in China
Tania Bubela2
Estimated H-index: 2
(SFU: Simon Fraser University),
Erika Kleiderman5
Estimated H-index: 5
(McGill University)
+ 4 AuthorsBartha Maria Knoppers49
Estimated H-index: 49
(McGill University)
Canada’s Assisted Human Reproduction Act is long overdue for Parliamentary review. We argue that the current regulation of research using human reproductive materials is not proportionate, not responsive to the uncertain threats posed to human and environmental health and safety, and is not considerate of diverse values in a democratic society. We propose tailored regulatory carve-outs for in vitro research for currently prohibited activities, such as gene editing, and for the exercise of Minist...
Published on Nov 1, 2018in European Journal of Medical Genetics2.02
Anna Middleton16
Estimated H-index: 16
(University of Cambridge),
Richard Milne6
Estimated H-index: 6
(University of Cambridge)
+ 11 AuthorsJames A. Smith65
Estimated H-index: 65
With the use of genetic technology, researchers have the potential to inform medical diagnoses and treatment in actionable ways. Accurate variant interpretation is a necessary condition for the utility of genetic technology to unfold. This relies on the ability to access large genomic datasets so that comparisons can be made between variants of interest. This can only be successful if DNA and medical data are donated by large numbers of people to 'research', including clinical, non-profit and fo...
Published on Jan 28, 2019in Canadian Medical Association Journal6.94
Bartha Maria Knoppers49
Estimated H-index: 49
(McGill University),
Erika Kleiderman5
Estimated H-index: 5
(McGill University)
KEY POINTS The response to the announcement in China on Nov. 25, 2018, of the “first clustered regularly interspaced short palindromic repeats [CRISPR] babies”[1][1] is reminiscent of that surrounding the 1978 birth by in vitro fertilization of Louise Brown, the “first test-tube baby.” Will
Vardit Ravitsky14
Estimated H-index: 14
(UdeM: Université de Montréal),
Minh Thu Nguyen2
Estimated H-index: 2
(McGill University)
+ 3 AuthorsBartha Maria Knoppers49
Estimated H-index: 49
(McGill University)
Abstract The use of pre-implantation genetic diagnosis (PGD) is increasing as the list of indications it can test for constantly expands. This raises new challenges for clinicians and prospective parents regarding possible uses and calls for guidance. Policy approaches towards PGD vary greatly worldwide. The 2004 Canadian Assisted Human Reproduction Act does not provide guidance, except for prohibiting non-medical sex selection. Criminal legislation is an unsuitable policy instrument to regulate...
Published on Dec 1, 2018in Human Genomics2.54
Adrian Thorogood9
Estimated H-index: 9
(McGill University),
Jason Bobe6
Estimated H-index: 6
(ISMMS: Icahn School of Medicine at Mount Sinai)
+ 8 AuthorsMj Murtagh22
Estimated H-index: 22
(Newcastle University)
There is a growing support for the stance that patients and research participants should have better and easier access to their raw (uninterpreted) genomic sequence data in both clinical and research contexts. We review legal frameworks and literature on the benefits, risks, and practical barriers of providing individuals access to their data. We also survey genomic sequencing initiatives that provide or plan to provide individual access. Many patients and research participants expect to be able...
Published on Dec 1, 2018in Stem Cell Research & Therapy4.63
Erika Kleiderman5
Estimated H-index: 5
(McGill University),
Audrey Boily1
Estimated H-index: 1
(McGill University)
+ 1 AuthorsBartha Maria Knoppers49
Estimated H-index: 49
(McGill University)
In the context of regenerative medicine and cellular therapies, the treatment under study often targets a less common disease or condition for which recruitment of a large number of research participants at any given site is challenging, if not impossible. One way to overcome this challenge is with a multi-centre clinical trial. This manuscript first aims to briefly outline the existing ethical, legal and social implications as well as the regulatory frameworks associated with multi-centre regen...
Published on Sep 1, 2018in Regenerative Medicine2.38
Seydina B. Touré2
Estimated H-index: 2
(McGill University),
Erika Kleiderman5
Estimated H-index: 5
(McGill University),
Bartha Maria Knoppers49
Estimated H-index: 49
(McGill University)
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