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Rebecca M. E. Steketee
Erasmus University Rotterdam
18Publications
7H-index
325Citations
Publications 19
Newest
#1Elisabeth J. Vinke (EUR: Erasmus University Rotterdam)H-Index: 1
#2Wyke Huizinga (EUR: Erasmus University Rotterdam)H-Index: 5
view all 12 authors...
textabstractBrain imaging data are increasingly made publicly accessible and volumetric imaging measures derived from population-based cohorts may serve as normative data for individual patient diagnostic assessment. Yet, these normative cohorts are usually not a perfect reflection of a patient’s base population, nor are imaging parameters such as field strength or scanner type similar. In this proof of principle study, we assessed differences between reference curves of subcortical structure vo...
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Phenocopy frontotemporal dementia (phFTD) shares core characteristics with behavioral variant frontotemporal dementia (bvFTD), yet without associated cognitive deficits and brain abnormalities on conventional magnetic resonance imaging (MRI), and without progression. Using advanced MRI techniques, we previously observed subtle structural and functional brain changes in phFTD similar to bvFTD. The aim of the current study was to follow these as well as cognition in phFTD over time, by means of a ...
Source
#1Rozanna MeijboomH-Index: 6
#2Rebecca M. E. Steketee (EUR: Erasmus University Rotterdam)H-Index: 7
Last.Marion Smits (EUR: Erasmus University Rotterdam)H-Index: 33
view all 8 authors...
Objectives This study explored group-wise quantitative measures of tract-specific white matter (WM) microstructure and functional default mode network (DMN) connectivity to establish an initial indication of their clinical applicability for early-stage and follow-up differential diagnosis of Alzheimer’s disease (AD) and behavioural variant frontotemporal dementia (bvFTD).
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#1Lieke H.H. Meeter (EUR: Erasmus University Rotterdam)H-Index: 8
#2Rebecca M. E. Steketee (EUR: Erasmus University Rotterdam)H-Index: 7
Last.John VanSwieten (EUR: Erasmus University Rotterdam)H-Index: 71
view all 47 authors...
Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we inves...
1 CitationsSource
#1Jan Petr (RIT: Rochester Institute of Technology)H-Index: 1
Last.Iris Asllani (RIT: Rochester Institute of Technology)H-Index: 5
view all 9 authors...
Objective Partial volume (PV) correction is an important step in arterial spin labeling (ASL) MRI that is used to separate perfusion from structural effects when computing the mean gray matter (GM) perfusion. There are three main methods for performing this correction: (1) GM-threshold, which includes only voxels with GM volume above a preset threshold; (2) GM-weighted, which uses voxel-wise GM contribution combined with thresholding; and (3) PVC, which applies a spatial linear regression algori...
2 CitationsSource
#1Meike W. Vernooij (EUR: Erasmus University Rotterdam)H-Index: 52
#2Bas Jasperse (EUR: Erasmus University Rotterdam)H-Index: 3
Last.Wiro J. Niessen (TU Delft: Delft University of Technology)H-Index: 7
view all 10 authors...
Objectives: To assesses whether automated brain image analysis with quantification of structural brain changes improves diagnostic accuracy in a memory clinic setting. Methods: In 42 memory clinic patients, we evaluated whether automated quantification of brain tissue volumes, hippocampal volume and white matter lesion volume improves diagnostic accuracy for Alzheimer's disease (AD) and frontotemporal dementia (FTD), compared to visual interpretation. Reference data were derived from a dementia-...
4 CitationsSource
#1Esther E. Bron (EUR: Erasmus University Rotterdam)H-Index: 13
#2Marion Smits (EUR: Erasmus University Rotterdam)H-Index: 33
Last.Stefan Klein (EUR: Erasmus University Rotterdam)H-Index: 31
view all 9 authors...
Objectives To investigate the added diagnostic value of arterial spin labelling (ASL) and diffusion tensor imaging (DTI) to structural MRI for computer-aided classification of Alzheimer's disease (AD), frontotemporal dementia (FTD), and controls.
20 CitationsSource
#2Meike W. VernooijH-Index: 52
Last.Marion SmitsH-Index: 33
view all 11 authors...
Source
#1Rozanna Meijboom (EUR: Erasmus University Rotterdam)H-Index: 6
#2Rebecca M. E. Steketee (EUR: Erasmus University Rotterdam)H-Index: 7
Last.Marion Smits (EUR: Erasmus University Rotterdam)H-Index: 33
view all 9 authors...
Objectives Phenocopy frontotemporal dementia (phFTD) is a rare and poorly understood clinical syndrome. PhFTD shows core behavioural variant FTD (bvFTD) symptoms without associated cognitive deficits and brain abnormalities on conventional MRI and without progression. In contrast to phFTD, functional connectivity and white matter (WM) microstructural abnormalities have been observed in bvFTD. We hypothesise that phFTD belongs to the same disease spectrum as bvFTD and investigated whether functio...
7 CitationsSource
#1Rozanna Meijboom (EUR: Erasmus University Rotterdam)H-Index: 6
#2Rebecca M. E. Steketee (EUR: Erasmus University Rotterdam)H-Index: 7
Last.Marion Smits (EUR: Erasmus University Rotterdam)H-Index: 33
view all 6 authors...
Semantic dementia (SD) and behavioral variant frontotemporal dementia (bvFTD), subtypes of frontotemporal dementia, are characterized by distinct clinical symptoms and neuroimaging features, with predominant left temporal grey matter (GM) atrophy in SD and bilateral or right frontal GM atrophy in bvFTD. Such differential hemispheric predilection may also be reflected by other neuroimaging features, such as brain connectivity. This study investigated white matter (WM) microstructure and functiona...
1 CitationsSource
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