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Bhaskar Dasgupta
Southend University Hospital NHS Foundation Trust
Physical therapyGiant cell arteritisPolymyalgia rheumaticaDiabetes mellitusMedicine
140Publications
35H-index
5,214Citations
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Publications 229
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#2Frances Borg (Southend University Hospital NHS Foundation Trust)H-Index: 3
Last. Bhaskar Dasgupta (Southend University Hospital NHS Foundation Trust)H-Index: 35
view all 8 authors...
We thank Ghajari and Sabour for their interest in our work and appreciation of our study.1 We have reported that the extent of vascular inflammation on ultrasound, as quantified by the halo score, is associated with ocular ischaemia in patients with giant cell arteritis (GCA).2 Furthermore, we investigated the diagnostic accuracy of the halo score for a clinical diagnosis of GCA, as well as a positive temporal artery biopsy.2 Here, we discuss the points raised by the authors. First, the authors ...
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#1John H. Stone (Harvard University)H-Index: 72
#2Helen Spotswood (Hoffmann-La Roche)H-Index: 4
Last. Carlo SalvaraniH-Index: 73
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Background: In part 1 of the 52-week, double-blind GiACTA trial, tocilizumab (TCZ) every week (QW) or every other week (Q2W) + prednisone tapering reduced the risk for flare versus placebo (PBO) + 26-week prednisone tapering among patients with new-onset giant cell arteritis (GCA) at baseline. Among patients with relapsing GCA, TCZ QW but not Q2W + prednisone reduced the risk for flare versus both PBO groups, and there was separation in the time to flare between the TCZ QW and Q2W groups.1 Objec...
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#1Alwin Sebastian (Southend University Hospital NHS Foundation Trust)
#2Abdul Kayani (Southend University Hospital NHS Foundation Trust)H-Index: 1
Last. Bhaskar Dasgupta (Southend University Hospital NHS Foundation Trust)H-Index: 35
view all 4 authors...
Background: Clinical presentation of GCA is protean. It is vital to make a secure diagnosis, exclude mimics urgently and avoid inappropriate steroids to minimise side effects. Fast track GCA clinics (FTC) provide rapid specialist assessment with temporal and axillary US (1). EULAR recommendations support US as first-choice test. A pre-test probability score (PTPS) stratifies patients to low (LC), intermediate (IC) and high-risk (HC) categories. Objectives: To validate a diagnostic GCA algorithm ...
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#1Jared Ching (MRC Mitochondrial Biology Unit)
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Abstract Giant cell arteritis (GCA) is the most common systemic vasculitis in the elderly 7 and is a potentially life-threatening ophthalmic emergency that can result in irreversible blindness without prompt treatment. Blindness is most commonly associated with acute onset, irreversible arteritic ischemic optic neuropathy (AION). Without treatment, second eye involvement may occur, resulting in bilateral blindness. Patients with established visual loss are treated with high dose steroids and gen...
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#2Frances Borg (Southend University Hospital NHS Foundation Trust)H-Index: 3
Last. Bhaskar Dasgupta (Southend University Hospital NHS Foundation Trust)H-Index: 35
view all 8 authors...
Objectives Ultrasound of temporal and axillary arteries may reveal vessel wall inflammation in patients with giant cell arteritis (GCA). We developed a ultrasound scoring system to quantify the extent of vascular inflammation and investigated its diagnostic accuracy and association with clinical factors in GCA. Methods This is a prospective study including 89 patients suspected of having GCA, of whom 58 had a confirmed clinical diagnosis of GCA after 6 months follow-up. All patients underwent bi...
3 CitationsSource
#1Bernhard Hellmich (University of Tübingen)H-Index: 37
#2Ana Filipa ÁguedaH-Index: 5
Last. Raashid Luqmani (University of Oxford)H-Index: 54
view all 26 authors...
Background Since the publication of the European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis (LVV) in 2009, several relevant randomised clinical trials and cohort analyses have been published, which have the potential to change clinical care and therefore supporting the need to update the original recommendations. Methods Using EULAR standardised operating procedures for EULAR-endorsed recommendations, the EULAR task force undertook a systemati...
48 CitationsSource
#1Sara Monti (UNIPV: University of Pavia)H-Index: 23
#2Cristina Ponte (IMM: Instituto de Medicina Molecular)H-Index: 6
Last. Raashid Luqmani (NOC: Nuffield Orthopaedic Centre)H-Index: 54
view all 13 authors...
OBJECTIVES: To develop a quantitative score based on colour duplex sonography (CDS) to predict the diagnosis and outcome of GCA. METHODS: We selected patients with positive CDS and confirmed diagnosis of GCA recruited into the TA Biopsy (TAB) vs Ultrasound in Diagnosis of GCA (TABUL) study and in a validation, independent cohort. We fitted four CDS models including combinations of the following: number and distribution of halos at the TA branches, average and maximum intima-media thickness of TA...
1 CitationsSource
#1Alwin Sebastian (Southend University Hospital NHS Foundation Trust)
#2Abdul Kayani (Southend University Hospital NHS Foundation Trust)H-Index: 1
Last. Bhaskar Dasgupta (Southend University Hospital NHS Foundation Trust)H-Index: 35
view all 3 authors...
We are grateful for the interest in our article and agree with Milchert et al 1 that the slope sign deserves a precise definition. Intimal medial thickness (IMT) of the axillary artery is the current way of assessing large vessel giant cell arteritis (LV-GCA) by ultrasound (US), with a cut-off value of greater than 1.0 mm suggesting LV-GCA.2 Other causes of arterial wall thickening can mimic vasculitis such as atherosclerosis and it …
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#1Bhaskar Dasgupta (Southend University Hospital NHS Foundation Trust)H-Index: 35
#2Kate SmithH-Index: 1
Last. Richard J. Wakefield (University of Leeds)H-Index: 58
view all 5 authors...
Ultrasound (US) scanning in the diagnosis of large vessel giant cell arteritis (LV-GCA) is becoming more prevalent, with the advantage of being non-invasive and free of ionising radiation.1 The recent European League against Rheumatism (EULAR) recommendations suggest that US should be the first-line investigation for cases of suspected GCA where adequate equipment and expertise is available.2 3 US is also having a more prominent role in disease monitoring. Biologics such as Tocilizumab have now ...
2 CitationsSource
#1K SmithH-Index: 68
#1Paul A. Lyons (University of Cambridge)H-Index: 42
Last. Catriona WallaceH-Index: 1
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This work was funded primarily by Project Grants from Arthritis Research UK (20593 to Drs. Smith and Lyons) and the British Heart Foundation (PG/13/64/30435 to Drs. Smith and Lyons). Additional support was provided by the NIHR Cambridge Biomedical Research Centre, the West Anglia Comprehensive Research Network, a Medical Research Council Programme Grant (MR/L019027/1 to Dr. Smith), a Wellcome Trust Investigator Award (200871/Z/16/Z to Dr. Smith), a NIHR Senior Investigator Award (to Dr. Smith), ...
11 CitationsSource
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