P. Zeitler
University of Colorado Denver
EndocrinologyType 2 diabetesType 2 Diabetes MellitusDiabetes mellitusMedicine
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Publications 8
#1P. Zeitler (University of Colorado Denver)H-Index: 5
#2Silva A. Arslanian (University of Pittsburgh)H-Index: 65
Last. David Maahs (Lucile Packard Children's Hospital)H-Index: 49
view all 9 authors...
8 CitationsSource
#1Lorraine E. Levitt Katz (Children's Hospital of Philadelphia)H-Index: 24
#2Fida Bacha (BCM: Baylor College of Medicine)H-Index: 33
Last. Janet H. Silverstein (UF: University of Florida)H-Index: 49
view all 199 authors...
Objectives Data regarding atherogenic dyslipidemia and the inflammation profile in youth with type 2 diabetes is limited and the effect of insulin therapy on these variables has not previously been studied in youth. We determined the impact of insulin therapy on lipid and inflammatory markers in youth with poorly controlled type 2 diabetes. Study design In the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) multicenter trial, 285 participants failed to sustain glycemic con...
3 CitationsSource
#1Petter Bjornstad (Anschutz Medical Campus)H-Index: 20
#2Edward Nehus (Cincinnati Children's Hospital Medical Center)H-Index: 12
Last. Janet H. SilversteinH-Index: 49
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Background Diabetic kidney disease is a major cause of premature mortality in type 2 diabetes mellitus (T2DM). Worsening insulin sensitivity independent of glycemic control may contribute to the development of diabetic kidney disease. We investigated the longitudinal association of insulin sensitivity with hyperfiltration and increased albumin excretion in adolescents with T2DM. Study Design Observational prospective cohort study. Setting & Participants 532 TODAY (Treatment Options for Type 2 Di...
11 CitationsSource
#1Samuel S. Gidding (Alfred I. duPont Hospital for Children)H-Index: 60
#2Fida Bacha (BCM: Baylor College of Medicine)H-Index: 33
Last. Janet H. Silverstein (UF: University of Florida)H-Index: 49
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Objectives To examine cardiac biomarkers over time in youth-onset type 2 diabetes, and relate serum concentrations to cardiovascular disease risk factors, and left ventricular structure and function. Study design TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) was a multicenter randomized trial of 3 treatments including 521 participants with type 2 diabetes, aged 10-17 years, and with 2-6 years of follow-up. Participants were 36% male, obese, and ethnically diverse. Annual...
2 CitationsSource
#1Megan M. Kelsey (CU: University of Colorado Boulder)H-Index: 11
#2Mitchell E. Geffner (SC: University of Southern California)H-Index: 39
Last. Janet H. Silverstein (UF: University of Florida)H-Index: 49
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#1Kristen J. Nadeau (University of Colorado Denver)H-Index: 31
#2P. Zeitler (University of Colorado Denver)H-Index: 5
Last. Judith G. Regensteiner (University of Colorado Denver)H-Index: 62
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Context: The incidence of pediatric type 2 diabetes (T2D) is rising, with unclear effects on the cardiovascular system. Cardiopulmonary fitness, a marker of morbidity and mortality, is abnormal in adults with T2D, yet the mechanisms are incompletely understood. Objective: We hypothesized that cardiopulmonary fitness would be reduced in youth with T2D in association with insulin resistance (IR) and cardiovascular dysfunction. Design, Setting, and Participants: We conducted a cross-sectional study...
123 CitationsSource
#1Dana Dabelea (University of Colorado Denver)H-Index: 69
Last. Richard F. Hamman (University of Colorado Denver)H-Index: 83
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OBJECTIVE—Limited data exist on the association between in utero exposure to maternal diabetes and obesity and type 2 diabetes in diverse youth. These associations were explored in African-American, Hispanic, and non-Hispanic white youth participating in the SEARCH Case-Control Study. RESEARCH DESIGN AND METHODS—A total of 79 youth with type 2 diabetes and 190 nondiabetic control youth aged 10–22 years attended a research visit. In utero exposures to maternal diabetes and obesity were recalled b...
226 CitationsSource
ABSTRACTBackground:Nonalcoholic fatty liver disease, a cause of chronic liver disease in obese adults also occurs in obese children. In susceptible populations, fatty liver progresses to nonalcoholic steatohepatitis and eventually to fibrosis and cirrhosis. Nonalcoholic steatohepatitis is associated
101 CitationsSource