Adam Steensberg
University of Copenhagen
Interleukin 6EndocrinologyPhysical exerciseGlycogenSkeletal muscle
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Publications 56
#2Adam SteensbergH-Index: 41
Last. Kirsten MøllerH-Index: 37
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#1Bente K. PedersenH-Index: 2
#2Adam SteensbergH-Index: 41
Last. Halkjaer-Kristensen JH-Index: 25
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#1Adam SteensbergH-Index: 41
#2Anders Dyhr ToftH-Index: 11
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You might find this additional info useful...This article cites€15 articles, 7 of which you can access for free at: article has been cited by€18 other HighWire-hosted articles: Updated information and services including high resolution figures, can be found at: material and information about Journal of Applied Physiology c...
#1Anders Dyhr Toft (UCPH: University of Copenhagen)H-Index: 11
#2A Falahati (Novo Nordisk)H-Index: 6
Last. Adam Steensberg (UCPH: University of Copenhagen)H-Index: 41
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The objective of this study was to use a novel and non-invasive model to explore whether: (1) exercise-induced increases in systemic levels of interleukin-6 (IL-6) and other cytokines can be ascribed to local production in working muscle; and (2) how acute release of retained blood from an exercised limb impacts on metabolites in the systemic circulation. On two experimental days, at least 3 weeks apart, six healthy moderately trained male subjects performed one-legged knee-extensor exercise for...
22 CitationsSource
#1Thorbjorn Akerstrom (UCPH: University of Copenhagen)H-Index: 21
#2Adam Steensberg (UCPH: University of Copenhagen)H-Index: 41
Last. Bente Klarlund Pedersen (UCPH: University of Copenhagen)H-Index: 116
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Retraction: The following article from The Journal of Physiology, ‘Exercise induces interleukin-8 expression in human skeletal muscle’, by Thorbjorn C. A. Akerstrom, Adam Steensberg, Pernille Keller, Charlotte Keller, Milena Penkowa and Bente Klarlund Pedersen, published in The Journal of Physiology 563(2): 507–516, and online ahead of print on 23 December 2004 (doi:10.1113/jphysiol.2004.077610), has been retracted by agreement between Thorbjorn C. A. Akerstrom, Adam Steensberg, Pernille Keller,...
#1Gerrit van Hall (UCPH: University of Copenhagen)H-Index: 33
#2Adam Steensberg (UCPH: University of Copenhagen)H-Index: 41
Last. Bente Klarlund Pedersen (UCPH: University of Copenhagen)H-Index: 116
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Context: IL-6 is a key modulator of immune function and suggested to be involved in skeletal muscle wasting as seen in sepsis. Objective: Our objective was to determine the role of IL-6 in human in vivo systemic and skeletal muscle amino acid metabolism and protein turnover. Subjects and Methods: There were 12 healthy men infused for 3 h with saline (saline, n = 6) or recombinant human IL (rhIL)-6 (n = 6). Systemic and muscle protein turnover was determined with a combination of tracer dilution ...
65 CitationsSource
#1Adam Steensberg (UCPH: University of Copenhagen)H-Index: 41
#2Charlotte Keller (UCPH: University of Copenhagen)H-Index: 37
Last. Mikael Sander (UCPH: University of Copenhagen)H-Index: 10
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Previous studies have described the magnitude and time course by which several genes are regulated within exercising skeletal muscle. These include interleukin-6 (IL-6), interleukin-8 (IL-8), heme oxygenase-1 (HO-1), and heat shock protein-72 (HSP72), which are involved in secondary signaling and preservation of intracellular environment. However, the primary signaling mechanisms coupling contraction to transcription are unknown. We hypothesized that exercise-induced nitric oxide (NO) production...
65 CitationsSource
#1Adam Steensberg (UCPH: University of Copenhagen)H-Index: 41
#2Mads K. Dalsgaard (UCPH: University of Copenhagen)H-Index: 17
Last. Bente Klarlund Pedersen (UCPH: University of Copenhagen)H-Index: 116
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Abstract During exercise the concentration of interleukin (IL)-6 and of heat shock protein (HSP) 72 increases in plasma, especially in fasting subjects. Both IL-6 and HSP72 are involved in a variety of metabolic and immunological processes, including some within the central nervous system and, accordingly, they are present not only in plasma but also in the cerebrospinal fluid (CSF). To evaluate whether, the two pools equilibrate we determined the levels of IL-6 and HSP72 in CSF, at a time when ...
43 CitationsSource
#1Charlotte KellerH-Index: 37
#2Ylva Hellsten (UCPH: University of Copenhagen)H-Index: 53
Last. Bente Klarlund PedersenH-Index: 116
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Abstract Interleukin-6 increases in skeletal muscle during exercise, and evidence points to Ca 2+ as an initiator of IL-6 production. However, the signalling pathway whereby this occurs is unknown. One candidate for Ca 2+ -mediated IL-6 induction is calcineurin, an activator of NF-AT. Here we investigated whether skeletal myocytes produce IL-6 in a Ca 2+ /calcineurin-dependent manner, and whether TNF-α, an inducer of IL-6, is affected by these stimuli. Human skeletal muscle cell cultures were st...
53 CitationsSource
#1Peter KrustrupH-Index: 60
#2Magni MohrH-Index: 37
Last. Jens BangsboH-Index: 72
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Purpose: To examine muscle and blood metabolites during soccer match play and relate it to possible changes in sprint performance. Methods: Thirty-one Danish fourth division players took part in three friendly games. Blood samples were collected frequently during the game, and muscle biopsies were taken before and after the game as well as immediately after an intense period in each half. The players performed five 30-m sprints interspersed by 25-s recovery periods before the game and immediatel...
446 CitationsSource