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Teresa Kral
Wroclaw University of Environmental and Life Sciences
24Publications
9H-index
237Citations
Publications 24
Newest
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 33
view all 3 authors...
The aim of the study was to investigate and compare the interaction of tributyltin (TBTA) and triphenyltin (TPhTA) 2-[4 (dimethylamino)phenylazo]benzoates complexes with the lipid membrane and plasmid DNA. Both TBTA and TPhTA belong to the group of promising anticancer agents. Differential scanning calorimetry method was employed to examine the heat signal associated with phase transitions of liposomes formed from dipalmitoylphosphatidylcholine (DPPC) or DPPC/cholesterol and modified with TBTA a...
2 CitationsSource
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 33
view all 3 authors...
Structural properties of plasmid DNA and model lipid membrane treated with newly synthesized platinum(II) complex cis-[PtCl2{P(CH2CH2COOH)3}2] (cis-DTCEP for short) were studied and compared with effects of anticancer drug cisplatin, cis-[Pt(NH3)2Cl2] (cis-DDP for short). Time Correlated Single Photon Counting Fluorescence Correlation Spectroscopy (TCSPC-FCS) was employed to study interactions between those platinum complexes and DNA. The TCSPC-FCS results suggest that bonding of cis-DTCEP deriv...
3 CitationsSource
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 33
view all 7 authors...
Abstract New butyltin complexes with 2-sulfobenzoic acid: [Sn(C4H9)2{O3SC6H4COO-2}(H2O)]·(C2H5OH) (DBTsbz), [Sn(C4H9)3{O3SC6H4COOH-2}] (TBTsbz) and [Sn2(C4H9)6{μ-O3SC6H4COO-2}] (DTBTsbz) are very effective cytotoxic agents against tumor cells. The molecular interaction of these complexes with lipid membranes and DNA has been investigated. The IR spectra and changes of 1H, 13C chemical shifts suggest that SO3 and COO groups of 2-sulfobenzoato ligand interact with O atom of glycerin fragment of DP...
7 CitationsSource
#1Teresa KralH-Index: 9
#2Hanna PruchnikH-Index: 11
Last.Martin HofH-Index: 33
view all 3 authors...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 11
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 33
view all 3 authors...
Organotin(IV) complexes show a wide variety of biological activity: bactericidal, fungicidal, caricidal, and pesticidal. Many of them are more effective than traditional heavy metal anticancer drugs. The aim of the present study was to investigate the interaction of a new dibutyltin complex with citric acid (DBTC) with lipid membrane and plasmid DNA. The effect of this compound on the multilamellar liposomes formed with dipalmitoylphosphatidylcholine, dimyristoylphosphatidylcholine, and dimyrist...
5 CitationsSource
#1Paweł Misiak (Wroclaw University of Environmental and Life Sciences)H-Index: 5
#2Kazimiera A. Wilk (Wrocław University of Technology)H-Index: 22
Last.Bożenna Różycka-Roszak (Wroclaw University of Environmental and Life Sciences)H-Index: 12
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Abstract New linear cationic surfactants – 2-(alkyldimethylammonio)ethylgluconamide bromides, denoted as C n GAB, n = 10, 12, 14 and 16 – were synthesized from natural resources and characterized with respect to their potential as gene-delivery agents in gene therapy applications. Interactions with plasmid DNA and with model membranes were studied both experimentally and theoretically. The compounds with n = 12, 14 and 16 show exponentially increasing ability to fully condense DNA. C 16 GAB cond...
14 CitationsSource
#1Marie BretonH-Index: 5
Last.Nathalie MignetH-Index: 19
view all 9 authors...
We assessed in this work how a chemical structure di erence could in" uence a supramolecular organiza- tion and then its biological properties. In our case study, we considered two amphiphilic lipidic gene vectors. The chemical dierence was situated on their hydrophilic part which was eitherapureneutralthioureaheadoramixtureofthreethiourea function derivatives, thiourea, iminothiol, and charged imi- nothiol. This small di$ erence was obtained thanks to the last chemicaldeprotectionconditionso...
7 CitationsSource
#1Gaelle Pembouong (French Institute of Health and Medical Research)H-Index: 2
#2Nelly Morellet (French Institute of Health and Medical Research)H-Index: 26
Last.Nathalie Mignet (French Institute of Health and Medical Research)H-Index: 19
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Abstract Poloxamers are triblock copolymers made of poly(ethylene glycol)–(poly(propylene glycol))–poly(ethylene glycol). They have been shown to enhance gene transfer in the muscle, and co-administration of polymers and DNA appeared to be crucial to obtain this effect. It is questionable then if some interaction occurs between polymers and DNA. Polymer interaction with membranes represents a second crucial point due to the central hydrophobic part of the triblock copolymers. Besides, the questi...
25 CitationsSource
#1Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
#2Jeanne LeblondH-Index: 12
Last.Nathalie MignetH-Index: 19
view all 6 authors...
Lipopolythioureas (LPT) are original non cationic systems representing an alternative to cationic lipids. Their high transfection efficiency prompted us to investigate further their biophysical properties, and in particular how thiourea lipids interact with DNA. The interaction of lipopolythiourea with DNA was investigated by fluorescence correlation microscopy (FCS). Influence of the lipid length and nature of the thiourea head on the thiourea/DNA interaction were studied. FCS revealed a strong...
15 CitationsSource
#1Jana Humpolíčková (CAS: Academy of Sciences of the Czech Republic)H-Index: 18
#2Miroslav Štěpánek (Charles University in Prague)H-Index: 13
Last.Martin Hof (CAS: Academy of Sciences of the Czech Republic)H-Index: 33
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The compaction of DNA plays a role in the nuclei of several types of cells and becomes important in the non-viral gene therapy. Thus, it is in the scope of research interest. It was shown, that spermine-induced compaction of large DNA molecules occurs in a discrete “all-or-non” regime, where the coexistence of free and folded DNA molecules was observed. In the case of intermediate-sized DNA molecules (~10 kbp), so far, it was stated that the mechanism of folding is continuous. Here, we show, tha...
9 CitationsSource
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