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Khadija Shahid
Riphah International University
11Publications
3H-index
31Citations
Publications 11
Newest
#1Adnan Jehangir (University of Health Sciences Lahore)
#2Muhammad Shahzad (University of Health Sciences Lahore)H-Index: 12
Last.Farhana Ayub (Riphah International University)
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Oleanolic acid (OA) is a hydroxyl pentacyclic triterpene acid (HTAs) used in various ailments. Inflammatory diseases may be profoundly influenced by iron (Fe) and zinc (Zn) status. We studied the anti-asthmatic effects of two metal complexes (Fe and Zn) of OA in the ovalbumin (OVA)-induced rat model. Delayed type hypersensitivity (DTH) was measured. Total and differential leucocyte count was done in blood as well as bronchoalveolar lavage fluid (BALF). The mRNA expression levels of pro-inflammat...
#1Kishwar SultanaH-Index: 3
Last.Khadija ShahidH-Index: 3
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Present research report elucidates the synthesis, chemistry and biological evaluation of metal complexes of the ligand 4-[(3-Bromophenyl)amino]-4-oxobutanoic acid. The ligand was synthesized by reacting bromo Substituted aniline with succinic anhydride by fusion technique under solvent free condition. The compound was then reacted with Zn (II), Fe (III) and Sb (III) chlorides to form metal complexes. The structures of ligand and complexes were confirmed by physical data, spectral evaluation incl...
#1Muafia Jabeen (Riphah International University)H-Index: 2
#2Sajjad Ahmad (University of Malakand)H-Index: 14
Last.Umer Rashid (CUI: COMSATS Institute of Information Technology)H-Index: 34
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In the current research work,eleven metal complexes were synthesized from the hydrazide derivative of ursolic acid. Metal complexes of tin, antimony and iron were synthesized and characterized by FT-IR and NMR spectroscopy. The antibacterial and antioxidant activities were performed for these complexes, which revealed that the metal complexes synthesized are more potent than their parent compounds. We observed that antioxidant activity showed by triphenyltin complex was significant and least act...
#1Asma Inam (University of Health Sciences Lahore)H-Index: 1
#2Muhammad Shahzad (University of Health Sciences Lahore)H-Index: 12
Last.Aqeel Javeed (UVAS: University of Veterinary and Animal Sciences)H-Index: 15
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Abstract Background Natural products have a prime importance as an essential source for new drug discovery. Carica papaya leaves (CPL) have been used to treat inflammation in traditional system of medicine. Aim/hypothesis Current study evaluates the anti-inflammatory and immunomodulatory effects of CPL extract using mouse model of ovalbumin- (OVA) induced allergic asthma. Methods All the mice were intraperitoneally sensitized and subsequently given intranasal challenge with OVA except the contro...
#1Farzana Shaheen (Allama Iqbal Open University)H-Index: 2
#2Muhammad Sirajuddin (University of Science and Technology)H-Index: 15
Last.Khadija Shahid (Riphah International University)H-Index: 3
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A series of tri- and diorganotin(IV) derivatives of 4-(2-thienyl)butyric acid have been synthesized by the reaction of ligand acid with tri- and diorganotin salts in 1:1 and 2:1 molar ratios, respectively. The synthesized compounds have been confirmed by CHNS elemental analyses, FTIR, multinuclear NMR (1H and 13C) spectroscopy and X-ray diffraction studies. NMR data reveal a 5-coordinate geometry for the triorganotin(IV) derivatives, while 6-coordinate for the diorganotin(IV) derivatives, respec...
#1Kishwar Sultana (UOL: University of Lahore)H-Index: 3
#2Sumera Zaib (CUI: COMSATS Institute of Information Technology)H-Index: 16
Last.Jamshed Iqbal (CUI: COMSATS Institute of Information Technology)H-Index: 26
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In the medical arena, advancements in the rational design of metal-based therapeutic agents showcase increasingly significant research efforts towards the development of new compounds with fewer toxic side effects. In this context, our present manuscript explicitly encapsulates the design and synthesis of Zn(II) complexes derived from different aryl acetamides, as potential frontline enzyme inhibitors as well as antileishmanial and anticancer agents. The structures of the synthesized metal compl...
#1Mohsin Abbas KhanH-Index: 2
#2Samar AkhtarH-Index: 2
Last.Khadija ShahidH-Index: 3
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Schiff base formation is a very important reaction of pharmaceutical chemistry. Schiff bases are gaining importance day by day as they have exhibited useful biological importance and are found to be a versatile pharmacophore for design and development of many bioactive compounds. Schiff’s bases of Phenyl hydrazine with the benzaldehyde, salicylaldehyde, cinnamonaldehyde, acetophenone and 2-hydroxyacetophenone were synthesized by condensation method. After the formation of the Schiff’s bases thei...
#1Samar AkhtarH-Index: 2
#2Mohsin Abbas KhanH-Index: 2
Last.Khadija ShahidH-Index: 3
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Organometallic chemistry is an emerging field combating diseases using unconventional perspectives, encompassing diagnostics and therapeutics, in healthcare. Physiochemical properties of organometallic complexes are quiet unique, which are now being used widely in medicinal inorganic chemistry. Results are quiet impressive as few organometallic complexes have entered clinical trials already. In foreseen future many more are expected to enter as well. Tin complexes of Nimesulide were efficiently ...
#1Kishwar SultanaH-Index: 2
#2Hassan KhanH-Index: 1
Last.Khadija ShahidH-Index: 3
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Hunting of new biologically active compounds is the need of time. Thanks to metals for being the charm of this field since more than half a century. Present report describes the synthesis, chemistry and biological evaluation of metal complexes of N-aryl phthalimides, a very interesting class of compounds in terms of their wide biological and chemical applications. Ortho anisidine is reacted with phthalic anhydride under solvent free condition to give N-substituted aryl phthalimide (Ligand A). Th...
#1Kishwar SultanaH-Index: 2
#2Hassan KhanH-Index: 1
Last.Khadija ShahidH-Index: 3
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Substituted N-aryl Phthalimides are an important class of compounds having various types of biological and chemical applications. Some substituted anilines were reacted with phthalic anhydride and acetic anhydride to give N-substituted aryl Phthalimides (L1-L5) and Acetamides (L6-L9) respectively. The reaction is done simply by fusion method by heating the two reactants together in the absence of any solvent and or catalyst. The reaction gave excellent yields ranging from 72 to 92%. The reaction...
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