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Sylvie Bortoli
Paris Descartes University
25Publications
7H-index
245Citations
Publications 25
Newest
Published on Dec 1, 2018in Biochimie Open
Sylvie Bortoli7
Estimated H-index: 7
(Paris Descartes University),
Martine Collinet9
Estimated H-index: 9
(Paris Descartes University),
Bernard Desbuquois1
Estimated H-index: 1
(Paris Descartes University)
Abstract Vanadate, a protein tyrosine phosphatase inhibitor which elicits insulin-like effects, has previously been shown to inhibit expression of the insulin receptor gene at the transcriptional level in rat hepatoma cells. In an attempt to identify the DNA sequence and transcription factors potentially involved in this effect, a fragment of the proximal 5′flanking region of the IR gene (−1143/−252 upstream the ATG codon) has been cloned and functionally characterized. RNase protection allowed ...
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Published on Apr 1, 2018in Revue Francophone Des Laboratoires
Paule Bénit35
Estimated H-index: 35
(French Institute of Health and Medical Research),
Sylvie Bortoli7
Estimated H-index: 7
(Paris Descartes University)
+ 2 AuthorsPierre Rustin79
Estimated H-index: 79
(French Institute of Health and Medical Research)
Resume Chez l'homme, les dysfonctions des enzymes du cycle de Krebs liees a des mutations causent des encephalopathies severes du jeune enfant, ou differents types de tumeurs et de cancers touchant differents organes. Ainsi des mutations des genes de la succinate-deshydrogenase ont ete identifiees dans des formes familiales de pheochromocytomes et paragangliomes. Les mutations du gene de la fumarase s'observent dans des leiomyomes uterins en association avec des cancers renaux, mais des cas d'en...
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Published on Apr 1, 2018in Current Opinion in Toxicology
Elisa Boutet-Robinet11
Estimated H-index: 11
(University of Toulouse),
Sylvie Bortoli7
Estimated H-index: 7
(Paris Descartes University),
Laurence Huc19
Estimated H-index: 19
(University of Toulouse)
Abstract Following exposure to xenobiotics, cellular mechanisms will take place to prevent damages relative to i) DNA, to maintain genome integrity, ii) proteins, to maintain their activities, iii) lipids, to limit peroxidation. This system of cellular defence and resistance is energetically costly. In this commentary review, we discuss the impact of DNA damage and the DNA damage response (DDR) on energetic metabolism. Conversely, we address the question about how energetic metabolism would infl...
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Published on Apr 1, 2018in Current Opinion in Toxicology
Sylvie Bortoli7
Estimated H-index: 7
(Paris Descartes University),
Elisa Boutet-Robinet11
Estimated H-index: 11
(University of Toulouse)
+ 1 AuthorsLaurence Huc19
Estimated H-index: 19
(University of Toulouse)
Abstract Beside their crucial role in xenobiotic biotransformation, AhR and Nrf2 are involved in the regulation of energetic metabolism. Nrf2, as a cytoprotective transcription factor, supply energy for detoxification and antioxidant response. AhR is ligand-activated transcriptional factor implicated in several physiological function. Following pollutant exposure, it acts as a chemosensor to eliminate harmful chemicals. Altogether, AhR and Nrf2 cooperate to contribute to protective responses upo...
3 Citations Source Cite
Published on Mar 27, 2018in bioRxiv
Paule Bénit35
Estimated H-index: 35
(French Institute of Health and Medical Research),
Sylvie Bortoli7
Estimated H-index: 7
(Paris Descartes University)
+ 6 AuthorsPierre Rustin79
Estimated H-index: 79
(French Institute of Health and Medical Research)
Succinate dehydrogenase inhibitors (SDHIs) are now widely used worldwide as fungicides to limit the proliferation of molds in cereal crops, or to better preserve fruits, vegetables, and seeds from these molds, as well as to facilitate the lawn care for public spaces and golf courses. According to the companies that produce them, the SDHIs quite specifically inhibit the activity of the succinate dehydrogenase in the molds. We here establish that these inhibitors readily inhibit the earthworm and ...
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Published on Jan 1, 2018
Sylvie Bortoli7
Estimated H-index: 7
,
Xavier Coumoul24
Estimated H-index: 24
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Published on Dec 1, 2017in Scientific Reports 4.12
Kévin Hardonnière6
Estimated H-index: 6
,
Morgane Fernier5
Estimated H-index: 5
+ 11 AuthorsMartine Chevanne14
Estimated H-index: 14
Most tumors undergo metabolic reprogramming towards glycolysis, the so-called Warburg effect, to support growth and survival. Overexpression of IF1, the physiological inhibitor of the F0F1ATPase, has been related to this phenomenon and appears to be a relevant marker in cancer. Environmental contributions to cancer development are now widely accepted but little is known about the underlying intracellular mechanisms. Among the environmental pollutants humans are commonly exposed to, benzo[a]pyren...
6 Citations Source Cite
Published on Dec 1, 2017in Scientific Reports 4.12
Elise Saunier3
Estimated H-index: 3
(Paris Descartes University),
Samantha Antonio3
Estimated H-index: 3
(Paris Descartes University)
+ 8 AuthorsLaurence Huc19
Estimated H-index: 19
(University of Toulouse)
Resveratrol (RES), a polyphenol found in natural foods, displays anti-oxidant, anti-inflammatory and anti-proliferative properties potentially beneficial in cancers, in particular in the prevention of tumor growth. However, the rapid metabolism of resveratrol strongly limits its bioavailability. The molecular mechanisms sustaining the potential biological activity of low doses of resveratrol has not been extensively studied and, thus, needs better characterization. Here, we show that resveratrol...
8 Citations Source Cite
Published on Dec 1, 2017in Scientific Reports 4.12
Ana A. Fernández-Ramos3
Estimated H-index: 3
(Paris Descartes University),
Catherine Marchetti-Laurent3
Estimated H-index: 3
(Paris Descartes University)
+ 7 AuthorsNicolas Pallet27
Estimated H-index: 27
(Paris Descartes University)
Metabolic reprogramming is critical for T cell fate and polarization and is regulated by metabolic checkpoints, including Myc, HIF-1α, AMPK and mTORC1. Our objective was to determine the impact of mycophenolic acid (MPA) in comparison with rapamycin (Rapa), an inhibitor of mTORC1, on the metabolism of Jurkat T cells. We identified a drug-specific transcriptome signature consisting of the key enzymes and transporters involved in glycolysis, glutaminolysis or nucleotide synthesis. MPA produced an ...
3 Citations Source Cite
Published on Sep 1, 2017in Nephrologie & Therapeutique 0.48
A.A. Fernandez Ramos (Paris Descartes University), C. Laurent-Marchetti (Paris Descartes University)+ 5 AuthorsNicolas Pallet27
Estimated H-index: 27
(Paris Descartes University)
Introduction La reprogrammation metabolique permet a la fois la proliferation rapide et la differenciation des cellules T au cours de l’activation lymphocytaire. Cette reorientation metabolique cruciale pour la fonction des cellules T est regulee par des points de controle (« metabolic checkpoints »), incluant Myc, HIF-1α, AMPK et mTOR. L’objectif du travail est de caracteriser les effets de l’acide mycophenolique (MPA) sur le metabolisme lymphocytaire par comparaison avec la rapamycine (rapa), ...
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