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Sylvie Bortoli
Paris Descartes University
EndocrinologyBiochemistryMetabolismBiologyPyruvate dehydrogenase complex
27Publications
8H-index
279Citations
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Publications 27
Newest
#1Alix F. Leblanc (Paris V: Paris Descartes University)H-Index: 4
#2Eléonore A. Attignon (Paris V: Paris Descartes University)H-Index: 2
Last. Etienne Blanc (Paris V: Paris Descartes University)H-Index: 8
view all 10 authors...
Abstract Individuals as well as entire ecosystems are exposed to mixtures of Persistent Organic Pollutants (POPs). Previously, we showed, by a non-targeted approach, that the expression of several genes involved in carbohydrate metabolism was almost completely inhibited in the human hepatic cell line HepaRG following exposure to a mixture of the organochlorine insecticide alpha-endosulfan and 2,3,7,8 tetrachlorodibenzo-p-dioxin. In this European HEALS project, which studies the effects of the ex...
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#1Carolina Duarte-Hospital (Paris V: Paris Descartes University)
#2Laurence Huc (INRA: Institut national de la recherche agronomique)H-Index: 20
Last. Xavier Coumoul (Paris V: Paris Descartes University)H-Index: 25
view all 4 authors...
Resume Les maladies metaboliques representent un probleme croissant en termes de sante publique. De nombreux polluants ou contaminants alimentaires sont suspectes de participer a l’emergence de ces pathologies par leur action en tant que perturbateurs endocriniens ou obesogenes. Dans cette revue, nous decrirons les nombreuses voies d’entree de ces xenobiotiques, de la production jusqu’a la consommation des aliments, ainsi que leurs differents modes d’action. Nous traiterons de molecules aussi di...
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#1Sylvie Bortoli (Paris V: Paris Descartes University)H-Index: 8
#2Martine Collinet (Paris V: Paris Descartes University)H-Index: 9
Last. Bernard Desbuquois (Paris V: Paris Descartes University)H-Index: 2
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Abstract Vanadate, a protein tyrosine phosphatase inhibitor which elicits insulin-like effects, has previously been shown to inhibit expression of the insulin receptor gene at the transcriptional level in rat hepatoma cells. In an attempt to identify the DNA sequence and transcription factors potentially involved in this effect, a fragment of the proximal 5′flanking region of the IR gene (−1143/−252 upstream the ATG codon) has been cloned and functionally characterized. RNase protection allowed ...
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#1Sylvie Bortoli (Paris V: Paris Descartes University)H-Index: 8
#2Elisa Boutet-Robinet (University of Toulouse)H-Index: 12
Last. Laurence Huc (University of Toulouse)H-Index: 20
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Abstract Beside their crucial role in xenobiotic biotransformation, AhR and Nrf2 are involved in the regulation of energetic metabolism. Nrf2, as a cytoprotective transcription factor, supply energy for detoxification and antioxidant response. AhR is ligand-activated transcriptional factor implicated in several physiological function. Following pollutant exposure, it acts as a chemosensor to eliminate harmful chemicals. Altogether, AhR and Nrf2 cooperate to contribute to protective responses upo...
5 CitationsSource
#1Paule Bénit (French Institute of Health and Medical Research)H-Index: 29
#2Sylvie Bortoli (Paris V: Paris Descartes University)H-Index: 8
Last. Pierre Rustin (French Institute of Health and Medical Research)H-Index: 80
view all 5 authors...
Resume Chez l'homme, les dysfonctions des enzymes du cycle de Krebs liees a des mutations causent des encephalopathies severes du jeune enfant, ou differents types de tumeurs et de cancers touchant differents organes. Ainsi des mutations des genes de la succinate-deshydrogenase ont ete identifiees dans des formes familiales de pheochromocytomes et paragangliomes. Les mutations du gene de la fumarase s'observent dans des leiomyomes uterins en association avec des cancers renaux, mais des cas d'en...
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#1Elisa Boutet-Robinet (University of Toulouse)H-Index: 12
#2Sylvie Bortoli (Paris V: Paris Descartes University)H-Index: 8
Last. Laurence Huc (University of Toulouse)H-Index: 20
view all 3 authors...
Abstract Following exposure to xenobiotics, cellular mechanisms will take place to prevent damages relative to i) DNA, to maintain genome integrity, ii) proteins, to maintain their activities, iii) lipids, to limit peroxidation. This system of cellular defence and resistance is energetically costly. In this commentary review, we discuss the impact of DNA damage and the DNA damage response (DDR) on energetic metabolism. Conversely, we address the question about how energetic metabolism would infl...
1 CitationsSource
#1Paule Bénit (French Institute of Health and Medical Research)H-Index: 29
#2Sylvie Bortoli (Paris V: Paris Descartes University)H-Index: 8
Last. Pierre Rustin (French Institute of Health and Medical Research)H-Index: 80
view all 9 authors...
Succinate dehydrogenase inhibitors (SDHIs) are now widely used worldwide as fungicides to limit the proliferation of molds in cereal crops, or to better preserve fruits, vegetables, and seeds from these molds, as well as to facilitate the lawn care for public spaces and golf courses. According to the companies that produce them, the SDHIs quite specifically inhibit the activity of the succinate dehydrogenase in the molds. We here establish that these inhibitors readily inhibit the earthworm and ...
3 CitationsSource
#1Sylvie BortoliH-Index: 8
#2Xavier CoumoulH-Index: 25
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#1Ana A. Fernández-Ramos (Paris V: Paris Descartes University)H-Index: 4
#2Catherine Marchetti-Laurent (Paris V: Paris Descartes University)H-Index: 3
Last. Nicolas Pallet (Paris V: Paris Descartes University)H-Index: 28
view all 10 authors...
Metabolic reprogramming is critical for T cell fate and polarization and is regulated by metabolic checkpoints, including Myc, HIF-1α, AMPK and mTORC1. Our objective was to determine the impact of mycophenolic acid (MPA) in comparison with rapamycin (Rapa), an inhibitor of mTORC1, on the metabolism of Jurkat T cells. We identified a drug-specific transcriptome signature consisting of the key enzymes and transporters involved in glycolysis, glutaminolysis or nucleotide synthesis. MPA produced an ...
4 CitationsSource
#1A.A. Fernandez Ramos (Paris V: Paris Descartes University)
#2C. Laurent-Marchetti (Paris V: Paris Descartes University)
Last. Nicolas Pallet (Paris V: Paris Descartes University)H-Index: 28
view all 8 authors...
Introduction La reprogrammation metabolique permet a la fois la proliferation rapide et la differenciation des cellules T au cours de l’activation lymphocytaire. Cette reorientation metabolique cruciale pour la fonction des cellules T est regulee par des points de controle (« metabolic checkpoints »), incluant Myc, HIF-1α, AMPK et mTOR. L’objectif du travail est de caracteriser les effets de l’acide mycophenolique (MPA) sur le metabolisme lymphocytaire par comparaison avec la rapamycine (rapa), ...
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