Sylvie Bortoli
Paris Descartes University
21Publications
6H-index
230Citations
Publications 21
Newest
Published on Dec 1, 2018in Biochimie Open
Sylvie Bortoli6
Estimated H-index: 6
(Paris Descartes University),
Martine Collinet9
Estimated H-index: 9
(Paris Descartes University),
Bernard Desbuquois1
Estimated H-index: 1
(Paris Descartes University)
Abstract Vanadate, a protein tyrosine phosphatase inhibitor which elicits insulin-like effects, has previously been shown to inhibit expression of the insulin receptor gene at the transcriptional level in rat hepatoma cells. In an attempt to identify the DNA sequence and transcription factors potentially involved in this effect, a fragment of the proximal 5′flanking region of the IR gene (−1143/−252 upstream the ATG codon) has been cloned and functionally characterized. RNase protection allowed ...
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Published on Apr 1, 2018in Revue Francophone Des Laboratoires
Paule Bénit34
Estimated H-index: 34
(French Institute of Health and Medical Research),
Sylvie Bortoli6
Estimated H-index: 6
(Paris Descartes University)
+ 2 AuthorsPierre Rustin79
Estimated H-index: 79
(French Institute of Health and Medical Research)
Resume Chez l'homme, les dysfonctions des enzymes du cycle de Krebs liees a des mutations causent des encephalopathies severes du jeune enfant, ou differents types de tumeurs et de cancers touchant differents organes. Ainsi des mutations des genes de la succinate-deshydrogenase ont ete identifiees dans des formes familiales de pheochromocytomes et paragangliomes. Les mutations du gene de la fumarase s'observent dans des leiomyomes uterins en association avec des cancers renaux, mais des cas d'en...
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Published on Mar 27, 2018in bioRxiv
Paule Bénit34
Estimated H-index: 34
(French Institute of Health and Medical Research),
Sylvie Bortoli6
Estimated H-index: 6
(Paris Descartes University)
+ 6 AuthorsPierre Rustin79
Estimated H-index: 79
(French Institute of Health and Medical Research)
Succinate dehydrogenase inhibitors (SDHIs) are now widely used worldwide as fungicides to limit the proliferation of molds in cereal crops, or to better preserve fruits, vegetables, and seeds from these molds, as well as to facilitate the lawn care for public spaces and golf courses. According to the companies that produce them, the SDHIs quite specifically inhibit the activity of the succinate dehydrogenase in the molds. We here establish that these inhibitors readily inhibit the earthworm and ...
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Published on Apr 1, 2018in Current Opinion in Toxicology
Elisa Boutet-Robinet11
Estimated H-index: 11
(University of Toulouse),
Sylvie Bortoli6
Estimated H-index: 6
(Paris Descartes University),
Laurence Huc14
Estimated H-index: 14
(University of Toulouse)
Abstract Following exposure to xenobiotics, cellular mechanisms will take place to prevent damages relative to i) DNA, to maintain genome integrity, ii) proteins, to maintain their activities, iii) lipids, to limit peroxidation. This system of cellular defence and resistance is energetically costly. In this commentary review, we discuss the impact of DNA damage and the DNA damage response (DDR) on energetic metabolism. Conversely, we address the question about how energetic metabolism would infl...
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Published on Apr 1, 2018in Current Opinion in Toxicology
Sylvie Bortoli6
Estimated H-index: 6
(Paris Descartes University),
Elisa Boutet-Robinet11
Estimated H-index: 11
(University of Toulouse)
+ 1 AuthorsLaurence Huc14
Estimated H-index: 14
(University of Toulouse)
Abstract Beside their crucial role in xenobiotic biotransformation, AhR and Nrf2 are involved in the regulation of energetic metabolism. Nrf2, as a cytoprotective transcription factor, supply energy for detoxification and antioxidant response. AhR is ligand-activated transcriptional factor implicated in several physiological function. Following pollutant exposure, it acts as a chemosensor to eliminate harmful chemicals. Altogether, AhR and Nrf2 cooperate to contribute to protective responses upo...
3 Citations Source Cite
Published on Dec 1, 2017in Scientific Reports 4.12
Kévin Hardonnière6
Estimated H-index: 6
(University of Rennes),
Morgane Fernier5
Estimated H-index: 5
(University of Rennes)
+ 11 AuthorsMichel Chevanne7
Estimated H-index: 7
(University of Rennes)
Most tumors undergo metabolic reprogramming towards glycolysis, the so-called Warburg effect, to support growth and survival. Overexpression of IF1, the physiological inhibitor of the F0F1ATPase, has been related to this phenomenon and appears to be a relevant marker in cancer. Environmental contributions to cancer development are now widely accepted but little is known about the underlying intracellular mechanisms. Among the environmental pollutants humans are commonly exposed to, benzo[a]pyren...
6 Citations Source Cite
Published on Dec 1, 2017in Scientific Reports 4.12
Elise Saunier3
Estimated H-index: 3
(Paris Descartes University),
Samantha Antonio3
Estimated H-index: 3
(Paris Descartes University)
+ 8 AuthorsLaurence Huc14
Estimated H-index: 14
(University of Toulouse)
Resveratrol (RES), a polyphenol found in natural foods, displays anti-oxidant, anti-inflammatory and anti-proliferative properties potentially beneficial in cancers, in particular in the prevention of tumor growth. However, the rapid metabolism of resveratrol strongly limits its bioavailability. The molecular mechanisms sustaining the potential biological activity of low doses of resveratrol has not been extensively studied and, thus, needs better characterization. Here, we show that resveratrol...
6 Citations Source Cite
Published on May 1, 2017in Molecular Nutrition & Food Research 5.15
Emilie Distel3
Estimated H-index: 3
(Paris Descartes University),
Thomas Cadoudal1
Estimated H-index: 1
(Paris Descartes University)
+ 3 AuthorsSylvie Bortoli6
Estimated H-index: 6
(Paris Descartes University)
cope Vitamin A and its metabolites, such as retinoic acids (RA), are related to metabolic diseases, in particular insulin resistance and obesity. Here, we studied the roles of 9-cis RA and all-trans RA on the regulation of pyruvate dehydrogenase kinase 4 (PDK4), an enzyme involved in fatty acid reesterification, which is a crucial metabolic pathway in adipose tissue (AT) lipid homeostasis. Methods and results 9-cis RA and all-trans RA treatment of human and murine AT explants, as well as adipocy...
2 Citations Source Cite
Published on Jun 27, 2017in Oncotarget
Ana A. Fernández-Ramos3
Estimated H-index: 3
,
Catherine Marchetti-Laurent3
Estimated H-index: 3
+ 5 AuthorsNicolas Pallet25
Estimated H-index: 25
// Ana A. Fernandez-Ramos 1, 2 , Catherine Marchetti-Laurent 1, 2 , Virginie Poindessous 1, 2 , Samantha Antonio 2, 3 , Pierre Laurent-Puig 1, 2, 4 , Sylvie Bortoli 2, 3 , Marie-Anne Loriot 1, 2, 4, * and Nicolas Pallet 1, 2, 4, * 1 INSERM UMR-S 1147, Centre Universitaire des Saints-Peres, 75006 Paris, France 2 Universite Paris Descartes, Sorbonne Paris Cite, 75006 Paris, France 3 INSERM UMR-S 1124, Centre Universitaire des Saints-Peres, 75006 Paris, France 4 Assistance Publique-Hopitaux de Pari...
4 Citations Source Cite
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