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Amit Mandoli
Radboud University Nijmegen
RUNX1Myeloid leukemiaCancer researchGeneticsBiology
25Publications
10H-index
1,179Citations
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Publications 27
Newest
#1Gaëlle Cordonnier (Paris V: Paris Descartes University)H-Index: 2
#2Amit Mandoli (Radboud University Nijmegen)H-Index: 10
Last. Jonathan BondH-Index: 9
view all 11 authors...
Summary Mutations and deletions of polycomb repressive complex (PRC) components are increasingly recognized to affect tumor biology in a range of cancers. However, little is known about how genetic alterations of PRC-interacting molecules such as the core binding factor (CBF) complex influence polycomb activity. We report that the acute myeloid leukemia (AML)-associated CBFβ-SMMHC fusion oncoprotein physically interacts with the PRC1 complex and that these factors co-localize across the AML geno...
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#1Esther Tijchon (Radboud University Nijmegen)H-Index: 7
#2Guoqiang Yi (Radboud University Nijmegen)H-Index: 3
Last. Joost H.A. Martens (Radboud University Nijmegen)H-Index: 30
view all 11 authors...
Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect normal hematopoiesis. The analysis of human AMLs has mostly been performed using end-point materials, such as cell lines and patient derived AMLs that also carry additional contributing mutations. The molecular effects of a single oncogenic hit, such as expression of the AML associated oncoprotein AML1-ETO on hematopoietic development and transformation into a (pre-) leukemic state still needs further investigation....
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#1Guoqiang Yi (Radboud University Nijmegen)H-Index: 3
#2Amit Mandoli (Radboud University Nijmegen)H-Index: 10
Last. Joost H.A. Martens (Radboud University Nijmegen)H-Index: 30
view all 15 authors...
The inv(16) acute myeloid leukemia-associated CBFβ-MYH11 fusion is proposed to block normal myeloid differentiation, but whether this subtype of leukemia cells is poised for a unique cell lineage remains unclear. Here, we surveyed the functional consequences of CBFβ-MYH11 in primary inv(16) patient blasts, upon expression during hematopoietic differentiation in vitro and upon knockdown in cell lines by multi-omics profiling. Our results reveal that primary inv(16) AML cells share common transcri...
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#1Guoqiang Yi (Radboud University Nijmegen)H-Index: 3
#2Albertus T. J. Wierenga (UMCG: University Medical Center Groningen)H-Index: 17
Last. Joost H.A. Martens (Radboud University Nijmegen)H-Index: 30
view all 27 authors...
Summary Global investigation of histone marks in acute myeloid leukemia (AML) remains limited. Analyses of 38 AML samples through integrated transcriptional and chromatin mark analysis exposes 2 major subtypes. One subtype is dominated by patients with NPM1 mutations or MLL-fusion genes, shows activation of the regulatory pathways involving HOX-family genes as targets, and displays high self-renewal capacity and stemness. The second subtype is enriched for RUNX1 or spliceosome mutations, suggest...
8 CitationsSource
#1Guoqiang YiH-Index: 3
#2Amit MandoliH-Index: 10
Last. Joost H.A. MartensH-Index: 30
view all 13 authors...
The inv(16) acute myeloid leukemia associated CBFβ-MYH11 fusion is proposed to block normal myeloid differentiation, but whether this subtype of leukemia cells is poised for a unique cell lineage remains unclear. Here, we surveyed the functional consequences of CBFβ-MYH11 in primary inv(16) patient blasts, upon expression during hematopoietic differentiation in vitro and upon knockdown in cell lines by multi-omics profiling. Our results reveal that primary inv(16) AML cells share common transcri...
Source
#1Katy Teo (Edin.: University of Edinburgh)H-Index: 1
#2Laura Gómez-Cuadrado (Edin.: University of Edinburgh)H-Index: 4
Last. Patrick W. B. Derksen (UU: Utrecht University)H-Index: 28
view all 15 authors...
Despite the fact that loss of E-cadherin is causal to the development and progression of invasive lobular carcinoma (ILC), options to treat this major breast cancer subtype are limited if tumours develop resistance to anti-oestrogen treatment regimens. This study aimed to identify clinically targetable pathways that are aberrantly active downstream of E-cadherin loss in ILC. Using a combination of reverse-phase protein array (RPPA) analyses, mRNA sequencing, conditioned medium growth assays and ...
5 CitationsSource
#1Anna E. Marneth (Radboud University Nijmegen)H-Index: 3
#2Lacramioara Botezatu (University of Duisburg-Essen)H-Index: 5
Last. Cyrus Khandanpour (University of Duisburg-Essen)H-Index: 12
view all 21 authors...
RUNX1/ETO (Acute Myeloid Leukemia 1-Eight Twenty One) is an onco-fusion protein produced as a consequence of the t(8;21)(q22;q22) translocation.[1][1] It functions as an aberrant transcription factor and contributes to AML development. We examined the role of the transcription factor Growth Factor
3 CitationsSource
#1Giovanni Iacono (Radboud University Nijmegen)H-Index: 9
#2Aline DubosH-Index: 5
Last. Hendrik G. Stunnenberg (Radboud University Nijmegen)H-Index: 89
view all 15 authors...
Kleefstra syndrome, a disease with intellectual disability, autism spectrum disorders and other developmental defects is caused in humans by haploinsufficiency of EHMT1. Although EHMT1 and its paralog EHMT2 were shown to be histone methyltransferases responsible for deposition of the di-methylated H3K9 (H3K9me2), the exact nature of epigenetic dysfunctions in Kleefstra syndrome remains unknown. Here, we found that the epigenome of Ehmt1+/- adult mouse brain displays a marked increase of H3K9me2/...
7 CitationsSource
#2Abhishek A. Singh (Radboud University Nijmegen)H-Index: 6
Last. Lucia AltucciH-Index: 49
view all 35 authors...
Epigenetic alterations have been associated with both pathogenesis and progression of cancer. By screening of library compounds, we identified a novel hybrid epi-drug MC2884, a HAT/EZH2 inhibitor, able to induce bona fide cancer-selective cell death in both solid and hematological cancers in vitro, ex vivo and in vivo xenograft models. Anticancer action was due to an epigenome modulation by H3K27me3, H3K27ac, H3K9/14ac decrease, and to caspase-dependent apoptosis induction. MC2884 triggered mito...
1 CitationsSource
#1Abhishek A. Singh (Radboud University Nijmegen)H-Index: 6
Last. Joost H.A. Martens (Radboud University Nijmegen)H-Index: 30
view all 31 authors...
// Abhishek A. Singh 1, * , Francesca Petraglia 2, * , Angela Nebbioso 2 , Guoqiang Yi 1 , Mariarosaria Conte 3 , Sergio Valente 4 , Amit Mandoli 1 , Lucia Scisciola 2 , Rik Lindeboom 1 , Hinri Kerstens 1 , Eva M. Janssen-Megens 1 , Farzin Pourfarzad 5 , Ehsan Habibi 1 , Kim Berentsen 1 , Bowon Kim 1 , Colin Logie 1 , Simon Heath 6 , Albertus T.J. Wierenga 7 , Laura Clarke 8 , Paul Flicek 8 , Joop H. Jansen 9 , Taco Kuijpers 5 , Marie Laure Yaspo 10 , Veronique Della Valle 11 , Olivier Bernard 1...
4 CitationsSource
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