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Marina Camera
University of Milan
EndocrinologyCardiologyTissue factorDiabetes mellitusMedicine
146Publications
31H-index
3,016Citations
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Publications 155
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#1Paolo Gelosa (University of Milan)H-Index: 23
#2Laura Castiglioni (University of Milan)H-Index: 10
Last. Luigi Sironi (University of Milan)H-Index: 32
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Abstract Drug repurposing is a promising way in drug discovery to identify new therapeutic uses -different from the original medical indication- for existing drugs. It has many advantages over traditional approaches to de novo drug discovery, since it can significantly reduce healthcare costs and development timeline. In this review, we discuss the possible repurposing of drugs approved for cardiovascular diseases, such as β-blockers, angiotensin converting enzyme inhibitors (ACE-Is), angiotensi...
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#1Paolo Gelosa (University of Milan)H-Index: 23
#2Laura Castiglioni (University of Milan)H-Index: 10
Last. Luigi Sironi (University of Milan)H-Index: 32
view all 4 authors...
Abstract Cardiovascular disease remains - despite the development of new drugs, devices, and therapeutic strategies- the leading cause of death and disability worldwide. There is therefore a great need to implement the pharmacological armamentarium, considering also the need to balance the therapeutic and the side effects. Furthermore, the best choice among the drug treatment options and reduction of side effects remain urgent problems for studies of cardiovascular disease. In this context, drug...
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#1Nicolas PerrotH-Index: 3
#2Donato MoschettaH-Index: 2
Last. Benoit J. ArsenaultH-Index: 30
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#1Nicola FerriH-Index: 27
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#1Sonia EliginiH-Index: 19
#2Nicola CosentinoH-Index: 14
Last. Elena TremoliH-Index: 63
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The prevalence of a macrophage phenotype in atherosclerotic plaque may drive its progression and/or instability. Macrophages from coronary plaques are not available, and monocyte-derived macrophages (MDMs) are usually considered as a surrogate. We compared the MDM profile obtained from coronary artery disease (CAD) patients and healthy subjects, and we evaluated the association between CAD MDM profile and in vivo coronary plaque characteristics assessed by optical coherence tomography (OCT). At ...
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#1Benedetta PorroH-Index: 10
#2Paola SongiaH-Index: 7
Last. Paolo PoggioH-Index: 12
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Mitral valve prolapse (MVP) is the most common cause of severe mitral regurgitation. It has been reported that MVP patients—candidates for mitral valve repair (MVRep)—showed an alteration in the antioxidant defense systems as well as in the L-arginine metabolic pathway. In this study, we investigate if oxidative stress and endothelial dysfunction are an MVP consequence or driving factors. Forty-five patients undergoing MVRep were evaluated before and 6 months post surgery and compared to 29 cont...
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Extracellular vesicles (EVs) are well-established mediators of cell-to-cell communication. EVs can be released by every cell type and they can be classified into three major groups according to their biogenesis, dimension, density, and predominant protein markers: exosomes, microvesicles, and apoptotic bodies. During their formation, EVs associate with specific cargo from their parental cell that can include RNAs, free fatty acids, surface receptors, and proteins. The biological function of EVs ...
1 CitationsSource
#1P. PignatelliH-Index: 1
#2Marina CameraH-Index: 31
Last. F. VioliH-Index: 1
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1 CitationsSource
#1Nicolas PerrotH-Index: 3
#2Donato MoschettaH-Index: 2
Last. Benoit J. ArsenaultH-Index: 30
view all 21 authors...
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition reduces plasma concentrations of low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB) and lipoprotein(a) [Lp(a)]. Atherogenic lipoprotein levels have been linked with calcific aortic valve stenosis (CAVS). Our objectives were to determine the association between variants in PCSK9 and lipoprotein-lipid levels, coronary artery disease (CAD) and CAVS, and to evaluate if PCSK9 could be implicated in aortic v...
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#1Patrizia AmadioH-Index: 7
#2Benedetta PorroH-Index: 10
Last. Silvia S. BarbieriH-Index: 16
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Circulating levels of Brain Derived Neurotrophic Factor (BDNF) are lower in coronary heart disease (CHD) than in healthy subjects and are associated with coronary events and mortality. However, the mechanism(s) underling this association is not fully understood. We hypothesize that BDNF may influence fibrin fiber structure and clot stability, favoring clot lysis and thrombus resolution. We showed that recombinant BDNF (rh-BDNF) influenced with clot formation in a concentration-dependent manner i...
1 CitationsSource
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