Urszula Demkow
Medical University of Warsaw
EndocrinologyImmunologyDiabetes mellitusMedicineBiology
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Publications 294
The aim of this prospective study was to assess the immunogenicity and safety of booster vaccine against diphtheria in children with inflammatory bowel disease on and without immunosuppression treatment. Immunoprotection was achieved in 93% of the children. No significant differences depending on the treatment used and no serious adverse events or flares of inflammatory bowel disease were observed.
#2Krzysztof Fiok (UCF: University of Central Florida)
Last. Urszula DemkowH-Index: 20
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Over a decade ago, the formation of neutrophil extracellular traps (NETs) was described as a novel mechanism employed by neutrophils to tackle infections. Currently applied methods for NETs release quantification are often limited by the use of unspecific dyes and technical difficulties. Therefore, we aimed to develop a fully automatic image processing method for the detection and quantification of NETs based on live imaging with the use of DNA-staining dyes. For this purpose, we adopted a recen...
The aim of the study was to determine the course and outcome of bacterial meningitis (BM) in patients with cancer. We retrospectively reviewed files of patients with community-acquired BM, hospitalized in a single neuroinfection center between January 2010 and December 2017. There were 209 patients included in the analysis: 28 had cancer (9 women, 19 men; median age 76, IQR 67–80 years) and 181 were cancer-free (76 women, 105 men; median age 52, IQR 33–65 years) and constituted the control group...
Under normal conditions, neutrophils are restricted from trafficking into the brain parenchyma and cerebrospinal fluid by the presence of the brain–blood barrier (BBB). Yet, infiltration of the central nervous system (CNS) by neutrophils is a well-known phenomenon in the course of different pathological conditions, e.g., infection, trauma or neurodegeneration. Different studies have shown that neutrophil products, i.e., free oxygen radicals and proteolytic enzymes, play an important role in the ...
1 CitationsSource
#1Aneta Manda-Handzlik (Medical University of Warsaw)H-Index: 5
#2Weronika Bystrzycka (Medical University of Warsaw)H-Index: 4
Last. Urszula Demkow (Medical University of Warsaw)H-Index: 20
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Despite great interest, the mechanism of neutrophil extracellular traps (NETs) release is not fully understood and some aspects of this process, e.g. the role of reactive nitrogen species (RNS), still remain unclear. Therefore, our aim was to investigate the mechanisms underlying RNS-induced formation of NETs and contribution of RNS to NETs release triggered by various physiological and synthetic stimuli. The involvement of RNS in NETs formation was studied in primary human neutrophils and diffe...
2 CitationsSource
#1Klaudyna Fidyt (Medical University of Warsaw)H-Index: 1
#2Agata Pastorczak (Medical University of Łódź)H-Index: 9
Last. Malgorzata Firczuk (Medical University of Warsaw)H-Index: 13
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B cell precursor acute lymphoblastic leukemia (BCP-ALL) is a genetically heterogeneous blood cancer characterized by abnormal expansion of immature B cells. Although intensive chemotherapy provides high cure rates in a majority of patients, subtypes harboring certain genetic lesions, such as MLL rearrangements or BCR-ABL1 fusion, remain clinically challenging, necessitating a search for other therapeutic approaches. Herein, we aimed to validate antioxidant enzymes of the thioredoxin system as po...
#1Michal Przemyslaw Pruchniak (Medical University of Warsaw)H-Index: 6
#2Magdalena Ostafin (Medical University of Warsaw)H-Index: 3
Last. Urszula Demkow (Medical University of Warsaw)H-Index: 20
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AbstractNeutrophils are one of the first cells to arrive at the site of infection, where they apply several strategies to kill pathogens: degranulation, respiratory burst, phagocytosis, and release...
1 CitationsSource
#1Arkadiusz Szarmach (Gdańsk Medical University)H-Index: 5
#2Marta A. Małkiewicz (Gdańsk Medical University)
Last. Pawel J. Winklewski (Gdańsk Medical University)H-Index: 11
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In this study we hypothesized that the alleviation of neurological symptoms long after internal carotid artery (ICA) stenting may be related to sustained improvement of cerebral perfusion. Thirty-four subjects (F/M; 15/19) with >70% stenosis of a single internal carotid artery and neurological symptoms, who underwent a carotid artery stenting procedure, were studied. Brain computed tomography perfusion (CTP) imaging was performed before and 3 years after ICA stenting. The following relative vari...
#1Małgorzata Rydzanicz (Medical University of Warsaw)H-Index: 20
#2Malgorzata Wachowska (Medical University of Warsaw)H-Index: 8
Last. Rafał Płoski (Medical University of Warsaw)H-Index: 36
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PPP3CA encodes calmodulin-binding catalytic subunit of calcineurin, a ubiquitously expressed calcium/calmodulin-regulated protein phosphatase. Recently de novo PPP3CA variants were reported as a cause of disease in 12 subjects presenting with epileptic encephalopathy and dysmorphic features. We describe a boy with similar phenotype and severe early onset epileptic encephalopathy in whom a novel de novo c.1324C>T (p.(Gln442Ter)) PPP3CA variant was found by whole exome sequencing. Western blot exp...