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Irene Brana
Autonomous University of Barcelona
64Publications
14H-index
799Citations
Publications 64
Newest
#1Mónica Pascual-García (Hebron University)
#2Ester Bonfill-Teixidor (Hebron University)
Last.Francisco Martinez-Ricarte (Hebron University)H-Index: 11
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Cancer response to immunotherapy depends on the infiltration of CD8+ T cells and the presence of tumor-associated macrophages within tumors. Still, little is known about the determinants of these factors. We show that LIF assumes a crucial role in the regulation of CD8+ T cell tumor infiltration, while promoting the presence of protumoral tumor-associated macrophages. We observe that the blockade of LIF in tumors expressing high levels of LIF decreases CD206, CD163 and CCL2 and induces CXCL9 exp...
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