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David C. Liewald
University of Edinburgh
Genome-wide association studyCognitionGeneticsLocus (genetics)Biology
127Publications
37H-index
5,665Citations
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Publications 133
Newest
#1Lisa de las Fuentes (WashU: Washington University in St. Louis)H-Index: 23
#2Yun Ju Sung (WashU: Washington University in St. Louis)H-Index: 18
Last. Alisa K. Manning (Harvard University)H-Index: 39
view all 222 authors...
Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects....
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#1Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
#2Daniel Trejo-Banos (UNIL: University of Lausanne)
Last. David C. Liewald (Edin.: University of Edinburgh)H-Index: 37
view all 19 authors...
The molecular factors which control circulating levels of inflammatory proteins are not well understood. Furthermore, association studies between molecular probes and human traits are often performed by linear model-based methods which may fail to account for complex structure and interrelationships within molecular datasets. Therefore, in this study, we perform genome- and epigenome-wide association studies (GWAS/EWAS) on the levels of 70 plasma-derived inflammatory protein biomarkers in health...
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#1Max LamH-Index: 10
#2Chen Chia-Yen (Harvard University)
Last. Laura M. Huckins (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 13
view all 69 authors...
Background: Cognitive traits demonstrate significant genetic correlations with many psychiatric disorders and other health-related traits, and many neuropsychiatric and neurodegenerative disorders are marked by cognitive deficits. Therefore, genome-wide association studies (GWAS) of general cognitive ability might suggest potential targets for nootropic drug repurposing. Our previous effort to identify "druggable genes" (i.e., GWAS-identified genes that produce proteins targeted by known small m...
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#1Colin R. Buchanan (Edin.: University of Edinburgh)H-Index: 3
#2Mark E. Bastin (Edin.: University of Edinburgh)H-Index: 52
Last. Simon R. Cox (Edin.: University of Edinburgh)H-Index: 20
view all 8 authors...
Abstract Whole-brain structural networks can be constructed using diffusion MRI and probabilistic tractography. However, measurement noise and the probabilistic nature of the tracking procedure result in an unknown proportion of spurious white matter connections. Faithful disentanglement of spurious and genuine connections is hindered by a lack of comprehensive anatomical information at the network-level. Therefore, network thresholding methods are widely used to remove ostensibly false connecti...
4 CitationsSource
#1W. David Hill (Edin.: University of Edinburgh)H-Index: 18
#2Neil M Davies (UoB: University of Bristol)H-Index: 23
Last. Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 17 authors...
Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing) multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 participants from UK Biobank, we identify 30 (29 previously unreported) independent-loci associated with income. Using a method to meta-analyze data from genetically-correlated traits, we identify an additional 120 income-associated loci. These loci show clear evidence of functionality, with transcriptional differences ide...
1 CitationsSource
#1Mihail Halachev (Edin.: University of Edinburgh)H-Index: 4
#2Alison Meynert (Edin.: University of Edinburgh)H-Index: 7
Last. James F. Wilson (Edin.: University of Edinburgh)H-Index: 3
view all 16 authors...
Human population isolates provide a snapshot of the impact of historical demographic processes on population genetics. Such data facilitate studies of the functional impact of rare sequence variants on biomedical phenotypes, as strong genetic drift can result in higher frequencies of variants that are otherwise rare. We present the first whole genome sequencing (WGS) study of the VIKING cohort, a representative collection of samples from the isolated Shetland population in northern Scotland, and...
Source
#1Mihail Halachev (Edin.: University of Edinburgh)H-Index: 4
#2Alison Meynert (Edin.: University of Edinburgh)H-Index: 7
Last. James F. Wilson (Edin.: University of Edinburgh)H-Index: 107
view all 16 authors...
Human population isolates provide a snapshot of the impact of historical demographic processes on population genetics. Such data facilitate studies of the functional impact of rare sequence variants on biomedical phenotypes, as strong genetic drift can result in higher frequencies of variants that are otherwise rare. We present the first whole genome sequencing (WGS) study of the VIKING cohort, a representative collection of samples from the isolated Shetland population in northern Scotland, and...
Source
#2Hieab H.H. Adams (EUR: Erasmus University Rotterdam)H-Index: 19
Last. M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 82
view all 289 authors...
1 CitationsSource
#2Hieab H.H. Adams (EUR: Erasmus University Rotterdam)H-Index: 19
Last. M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 82
view all 289 authors...
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysi...
5 CitationsSource
#1Max Lam (Broad Institute)H-Index: 5
#1Max Lam (Broad Institute)H-Index: 10
Last. Todd Lencz (Hofstra University)H-Index: 6
view all 68 authors...
Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic correlation has been reported between schizophrenia and educational attainment, despite the strong positive genetic correlation between cognitive ability and educational attainment. Here we leverage published genome-wide association studies (GWASs) in cognitive ability, education, and schizophrenia to parse bi...
3 CitationsSource
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