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Ivana Perković
University of Zagreb
55Publications
10H-index
240Citations
Publications 57
Newest
Abstract Harmicines constitute novel hybrid compounds that combine two agents with reported antiplasmodial properties, namely β-carboline harmine and a cinnamic acid derivative (CAD). Cu(I) catalyzed azide-alkyne cycloaddition was employed for the preparation of three classes of hybrid molecules: N-harmicines 6a-i, O-harmicines 7a-i and N,O-bis-harmicines 8a-g,i. In vitro antiplasmodial activities of harmicines against the erythrocytic stage of Plasmodium falciparum (chloroquine-sensitive Pf3D7 ...
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#1Branka Zorc (University of Zagreb)H-Index: 18
#2Zrinka Rajić (University of Zagreb)H-Index: 8
Last.Ivana Perković (University of Zagreb)H-Index: 10
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#1Branka Zorc (University of Zagreb)H-Index: 18
#2Ivana Perković (University of Zagreb)H-Index: 10
Last.Maja Beus (University of Zagreb)H-Index: 1
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Abstract Numerous modifications of the well-known antimalarial drug primaquine, both at the quinoline ring and at the primary amino group, have been reported, mostly to obtain antimalarial agents with improved bioavailability, reduced toxicity and/or prolonged activity. Modifications of the terminal amino group were made with the main idea to prevent the metabolic pathway leading to inactive and toxic carboxyprimaquine (follow-on strategy), but also to get compounds with different activity (repu...
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#2Bruno Lopes AbbadiH-Index: 4
Last.Zrinka RajićH-Index: 8
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#1Kristina Pavić (University of Zagreb)H-Index: 6
#2Zrinka Rajić (University of Zagreb)H-Index: 8
Last.Branka Zorc (University of Zagreb)H-Index: 18
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2 CitationsSource
#1Ivana PerkovićH-Index: 10
#2Maja BeusH-Index: 2
Last.Branka ZorcH-Index: 18
view all 4 authors...
#1Ivana PerkovićH-Index: 10
#2Zrinka RajićH-Index: 8
Last.Zrinka RajićH-Index: 8
view all 4 authors...
Last.Zrinka RajićH-Index: 8
view all 4 authors...
Od malarije umire vise djece do 5 godina starosti nego od bilo koje druge zarazne bolesti. Siroko je rasprostranjena u gusto naseljenim tropskim i subtropskim podrucjima Južne Azije, Afrike i Južne Amerike. U 2017. godini bilo je 219 milijuna novih slucajeva i 435 000 smrtnih ishoda (1). Malariju uzrokuje pet vrsta nametnika iz roda Plasmodium, od kojih P. falciparum uzrokuje najteži oblik bolesti. Parazit ima složeni životni ciklus koji ukljucuje 2 domacina, covjeka i komarca roda Anopheles (2)...
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