Grant C.B. Sinnamon
James Cook University
Genome-wide association studyPsychiatryPsychologyMajor depressive disorderAnxiety
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Publications 19
#1Azmeraw T. Amare (University of Adelaide)H-Index: 45
#2Klaus Oliver Schubert (University of Adelaide)H-Index: 9
Last. Yi-Hsin Hsu (Harvard University)H-Index: 40
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Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtain...
#1Darina Czamara (MPG: Max Planck Society)H-Index: 6
#2Gökcen Eraslan (TUM: Technische Universität München)H-Index: 6
Last. Elisabeth B. Binder (MPG: Max Planck Society)H-Index: 73
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Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overal...
2 CitationsSource
#1Darina CzamaraH-Index: 6
Last. Rebecca M. ReynoldsH-Index: 68
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#1Miruna C. Barbu (Edin.: University of Edinburgh)H-Index: 7
#2Thalia C. Eley (Medical Research Council)H-Index: 58
Last. Jorge A. Quiroz (Edin.: University of Edinburgh)H-Index: 25
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Background: Major depressive disorder is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome and have reported growing evidence of NETRIN1 pathway involvement. Stratifying disease risk by genetic variation within the NETRIN1 pathway may provide important routes for identification of disease mechanisms by focusing on a specific process, excluding heterogeneous risk-ass...
3 CitationsSource
#1Simone de Jong (Centre for Mental Health)H-Index: 16
#2Mateus Jose Abdalla Diniz (UNIFESP: Federal University of São Paulo)H-Index: 2
Last. Julia ShiH-Index: 54
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Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patter...
2 CitationsSource
#1Verneri Anttila (Broad Institute)H-Index: 35
#2Brendan Bulik-Sullivan (Broad Institute)H-Index: 24
Last. Benjamin M. Neale (Broad Institute)H-Index: 91
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Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from ...
264 CitationsSource
#1Robert Culverhouse (WashU: Washington University in St. Louis)H-Index: 20
#2Nancy L. Saccone (WashU: Washington University in St. Louis)H-Index: 44
Last. Laura J. Bierut (WashU: Washington University in St. Louis)H-Index: 72
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The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated much interest, research and controversy since first proposed in 2003. Multiple meta-analyses combining results from heterogeneous analyses have not settled the issue. To determine the magnitude of the interaction and the conditions under which it might be observed, we performed new analyses o...
76 CitationsSource
#1Robert CulverhouseH-Index: 20
#2Nancy L. SacconeH-Index: 44
Last. Laura J. BierutH-Index: 72
view all 93 authors...
1 Citations
#1Nese Direk (Dokuz Eylül University)H-Index: 18
#2Stephanie Williams (UNC: University of North Carolina at Chapel Hill)H-Index: 10
Last. Patrick F. Sullivan (KI: Karolinska Institutet)H-Index: 116
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BACKGROUND: The genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder. METHODS: We analyzed two prior ...
34 CitationsSource
#1Nese DirekH-Index: 18
#2Stephanie WilliamsH-Index: 10
Last. Douglas BlackwoodH-Index: 70
view all 102 authors...