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Masaru Ikejiri
Dainippon Sumitomo Pharma Co., Ltd.
9Publications
5H-index
71Citations
Publications 9
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Source
#1Manato KotaniH-Index: 4
#2Takeshi EnomotoH-Index: 7
Last.Kazuhito IkedaH-Index: 6
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Abstract Antagonism of the dopamine D 3 receptor is considered a promising strategy for the treatment of cognitive impairment associated with schizophrenia. We have previously reported that the atypical antipsychotic blonanserin, a dopamine D 2 /D 3 and serotonin 5-HT 2A receptor antagonist, highly occupies dopamine D 3 receptors at its antipsychotic dose range in rats. In the present study, we evaluated the effects of blonanserin on executive function in common marmosets using the object retrie...
4 CitationsSource
#1Manato KotaniH-Index: 4
#2Akihiko KiyoshiH-Index: 4
Last.Kazuhito IkedaH-Index: 6
view all 9 authors...
Eye blinking is a spontaneous behavior observed in all mammals, and has been used as a well-established clinical indicator for dopamine production in neuropsychiatric disorders, including Parkinson’s disease and Tourette syndrome [1] ; [2]. Pharmacological studies in humans and non-human primates have shown that dopamine agonists/antagonists increase/decrease eye blinking rate. Common marmosets (Callithrix jacchus) have recently attracted a great deal of attention as suitable experimental animal...
11 CitationsSource
#1Tomokazu NakakoH-Index: 7
#2Takeshi MuraiH-Index: 5
Last.Kazuhito IkedaH-Index: 6
view all 11 authors...
Abstract Infants with autism have difficulties performing joint visual attention (JVA), defined as following another person's pointing gesture and gaze. Some non-human primates (NHPs) can also perform JVA. Most preclinical research on autism spectrum disorders (ASD) has used rodents as animal models of this social interaction disorder. However, models using rodents fail to capture the complexity of social interactions that are disrupted in ASD. Therefore, JVA impairment in NHPs might be a more u...
5 CitationsSource
#1Takeshi MuraiH-Index: 5
#2Tomokazu NakakoH-Index: 7
Last.Kazuhito IkedaH-Index: 6
view all 6 authors...
Source
#1Takeshi Murai (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 5
#2Tomokazu Nakako (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 7
Last.Mutsuo Taiji (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 24
view all 6 authors...
Abstract We previously demonstrated among several antipsychotics exhibiting potent dopamine D 2 receptor antagonism that only lurasidone, (1R,2S,3R,4S)- N -[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinylmethyl]-1-cyclohexylmethyl]-2,3-bicyclo[2.2.1] heptanedicarboximide hydrochloride, improved performance in the object retrieval detour (ORD) task by marmosets. The mechanisms by which only lurasidone causes enhancements in cognitive function have not yet been established; however, most anti...
19 CitationsSource
Source
#1Tomokazu Nakako (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 7
#2Takeshi Murai (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 5
Last.Kazuhito Ikeda (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 6
view all 6 authors...
Abstract It is considered that functional deficiency of the NMDA receptors in the prefrontal cortex (PFC) is one of the causes of the cognitive impairment observed in schizophrenia. As non-human primates display more developed PFC than rodents, they are considered to be useful experimental animals for improving the predictive validity of models used to discover new drugs for treating cognitive dysfunction. The aim of this study was to develop a convenient model of the cognitive impairment observ...
18 CitationsSource
#1Takeshi Murai (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 5
#2Tomokazu Nakako (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 7
Last.Kazuhito Ikeda (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 6
view all 6 authors...
Abstract Cognitive impairment is one of the major symptoms of schizophrenia, and is considered largely due to dysfunctions in the prefrontal cortex (PFC). Lurasidone, a novel atypical antipsychotic agent with high binding affinity for dopamine D 2 , serotonin 5-HT 7 , 5-HT 2A and 5-HT 1A receptors has been reported to have superior efficacy in rodents’ models of cognitive impairment. However, the beneficial effect of lurasidone on cognitive impairment has not been evaluated in non-human primates...
14 CitationsSource
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