H. Valerie Curran
University College London
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Publications 138
#1Chandni Hindocha (UCL: University College London)H-Index: 13
#2Diego Quattrone (Mental Health Foundation)H-Index: 10
Last. M. Di Forti (Mental Health Foundation)H-Index: 36
view all 10 authors...
Epidemiological and biological evidence support the association between heavy cannabis use and psychosis. However, it is unclear which cannabis users are susceptible to its psychotogenic effect. Therefore, understanding genetic factors contributing to this relationship might prove an important strategy to identify the mechanisms underlying cannabis-associated psychotic experiences. We aimed to determine how variation in AKT1, COMT and FAAH genotypes, and their interaction with three different gr...
#1Claire Mokrysz (UCL: University College London)H-Index: 10
#2Natacha D. C. Shaban (UCL: University College London)H-Index: 3
Last. Cja Morgan (University of Exeter)H-Index: 36
view all 12 authors...
BACKGROUND: Acute cannabis administration can produce transient psychotic-like effects in healthy individuals. However, the mechanisms through which this occurs and which factors predict vulnerability remain unclear. We investigate whether cannabis inhalation leads to psychotic-like symptoms and speech illusion; and whether cannabidiol (CBD) blunts such effects (study 1) and adolescence heightens such effects (study 2). METHODS: Two double-blind placebo-controlled studies, assessing speech illus...
#1Gill Terrett (ACU: Australian Catholic University)H-Index: 8
#2Kimberly Mercuri (ACU: Australian Catholic University)H-Index: 4
Last. Peter G. Rendell (ACU: Australian Catholic University)H-Index: 31
view all 7 authors...
Background:Long-term opiate users experience pervasive social difficulties, but there has been surprisingly limited research focused on social-cognitive functioning in this population.Aim:The aim o...
#1Bobby P Smyth (Trinity College, Dublin)H-Index: 18
#2Mary Cannon (RCSI: Royal College of Surgeons in Ireland)H-Index: 53
Last. Adam R. Winstock (UCL: University College London)H-Index: 35
view all 6 authors...
Removing criminal penalties for possession could increase adolescent use, say Bobby P Smyth, Mary Cannon, and Andrew Molodynski. But H Valerie Curran, Niamh Eastwood, and Adam R Winstock find no evidence for this and say that liberalisation of drug laws could reduce harms
#1Meryem GrabskiH-Index: 4
#2H. Valerie Curran (UCL: University College London)H-Index: 43
Last. Marcus R. Munafò (UoB: University of Bristol)H-Index: 67
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Abstract Introduction Given the low efficacy of smoking cessation methods, an experimental medicine model indicating smoking abstinence would be of great benefit to the development of new treatments. Hence the sensitivity of cognitive tasks and ambulatory craving measures to smoking abstinence were investigated. Methods Cognitive tasks and ambulatory ratings of craving were assessed for sensitivity to acute abstinence (experiment 1), and nicotine replacement therapy administration (NRT) (experim...
#1Abigail M. Freeman (UCL: University College London)H-Index: 2
#2Katherine Petrilli (UCL: University College London)H-Index: 1
Last. Tom P. Freeman (UCL: University College London)H-Index: 22
view all 8 authors...
Abstract The recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9-tetrahydrocannabinol (THC), but this has never been reviewed systematically. In this systematic review of how CBD influences the acute effects of THC we identified 16 studies involving 466 participants. Ten studies were judged at low risk of bias. The fin...
4 CitationsSource
#1H. Valerie CurranH-Index: 43
#2Chandni HindochaH-Index: 13
Last. Tom P. FreemanH-Index: 22
view all 6 authors...
#1Chandni Hindocha (UCL: University College London)H-Index: 13
#2Tom P. FreemanH-Index: 22
Last. H. Valerie Curran (UCL: University College London)H-Index: 43
view all 8 authors...
1 CitationsSource
#1Hina Akram (UCL: University College London)H-Index: 1
#2Claire Mokrysz (UCL: University College London)H-Index: 10
Last. H. Valerie Curran (UCL: University College London)H-Index: 43
view all 3 authors...
Background:Synthetic cannabinoids are, typically, full agonists at the cannabinoid CB1 receptor, and therefore considerably more potent than natural cannabis and may have correspondingly more serio...
2 CitationsSource
#1Cja Morgan (University of Exeter)H-Index: 36
#2Tom P. Freeman (UCL: University College London)H-Index: 22
Last. H. Valerie Curran (UCL: University College London)H-Index: 4
view all 6 authors...
The main active ingredient in cannabis, delta-9-tetrahydrocannabinol (THC), can acutely induce psychotic symptoms and impair episodic and working memory. Another major constituent, cannabidiol (CBD), may attenuate these effects. This study aimed to determine the effects of THC and CBD, both alone and in combination on psychotic symptoms and memory function. A randomised, double-blind crossover design compared the effects of (i) placebo, (ii) THC 8 mg, (iii) CBD 16 mg and (iv) THC 8 mg + CBD 16 m...
10 CitationsSource