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H. Valerie Curran
University College London
125Publications
41H-index
5,216Citations
Publications 125
Newest
Published on Apr 23, 2019in Journal of Psychopharmacology 4.22
Matthew B. Wall19
Estimated H-index: 19
(UCL: University College London),
Rebecca Anne Pope3
Estimated H-index: 3
(UCL: University College London)
+ 10 AuthorsAbigail M. Freeman (UCL: University College London)
Background:Two major constituents of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main psychoactive component; CBD may buffer the user against the harmful effects of THC.Aims:We examined the effects of two strains of cannabis and placebo on the human brain’s resting-state networks using fMRI.Methods:Seventeen healthy volunteers (experienced with cannabis, but not regular users) underwent three drug treatments and scanning sessions. Treatments were cannabis contain...
Published on Apr 23, 2019in Addiction Biology 4.22
Chandni Hindocha10
Estimated H-index: 10
(UCL: University College London),
Tom P. Freeman20
Estimated H-index: 20
+ 5 AuthorsH. Valerie Curran41
Estimated H-index: 41
(UCL: University College London)
Published on Mar 1, 2019in Journal of Psychopharmacology 4.22
Hina Akram1
Estimated H-index: 1
(UCL: University College London),
Claire Mokrysz9
Estimated H-index: 9
(UCL: University College London),
H. Valerie Curran41
Estimated H-index: 41
(UCL: University College London)
Background:Synthetic cannabinoids are, typically, full agonists at the cannabinoid CB1 receptor, and therefore considerably more potent than natural cannabis and may have correspondingly more serious psychological effects. Despite government sanctions against their production they continue to be available in ever-increasing varieties over the Internet. The psychological consequences of synthetic cannabinoid use are relatively unknown.Aim:The purpose of this study was to synthesise the available ...
Published on Jun 7, 2018in Nicotine & Tobacco Research 3.79
Will Lawn8
Estimated H-index: 8
(UCL: University College London),
Tom P. Freeman20
Estimated H-index: 20
(UCL: University College London)
+ 6 AuthorsH. Valerie Curran41
Estimated H-index: 41
(UCL: University College London)
Background: Dopaminergic functioning is thought to play critical roles in both motivation and addiction. There is preliminary evidence that dopamine agonists reduce the motivation for cigarettes in smokers. However, the effects of pramipexole, a dopamine D3 receptor preferring agonist, have not been investigated. The aim of this study was to examine the effects of an acute dose of pramipexole on the motivation to earn cigarettes and nondrug rewards. Methods: Twenty dependent and 20 occasional sm...
Published on Jan 1, 2018in The International Journal of Neuropsychopharmacology 4.21
Tom P. Freeman20
Estimated H-index: 20
(UCL: University College London),
Rebecca Anne Pope3
Estimated H-index: 3
(UCL: University College London)
+ 10 AuthorsMichael A P Bloomfield8
Estimated H-index: 8
(UCL: University College London)
Background: Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here, we investigate the effects of cannabis on listening to music, a rewarding activity that frequently occurs in the context of recreational cannabis use. We additionally tested how these effects are influenced by cannabidiol, which may offset cannabis-related harms. Methods: Across 3 sessions, 16 cannabis users inhaled cannabis with cannabidiol, cannabi...
Published on Dec 1, 2017in Scientific Reports 4.01
Robin L. Carhart-Harris26
Estimated H-index: 26
(Imperial College London),
Leor Roseman11
Estimated H-index: 11
(Imperial College London)
+ 10 AuthorsKevin Murphy38
Estimated H-index: 38
(Cardiff University)
Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD). Quality pre and post treatment fMRI data were collected from 16 of 1...
Published on Nov 1, 2017in Psychopharmacology 3.42
Chandni Hindocha10
Estimated H-index: 10
(UCL: University College London),
Will Lawn8
Estimated H-index: 8
(UCL: University College London)
+ 1 AuthorsH. Valerie Curran41
Estimated H-index: 41
(UCL: University College London)
Rationale Cannabis and tobacco are often smoked simultaneously in joints, and this practice may increase the risks of developing tobacco and/or cannabis use disorders. Currently, there is no human experimental research on how these drugs interact on addiction-related measures.
Published on Aug 1, 2017
Chandni Hindocha10
Estimated H-index: 10
(UCL: University College London),
Tom P. Freeman20
Estimated H-index: 20
,
H. Valerie Curran41
Estimated H-index: 41
(UCL: University College London)
Abstract Introduction: Major gaps exist in the measurement of cannabis exposure. The accuracy of self-reported cannabis and tobacco dose per joint is poorly characterized and has never been investigated following acute cannabis/tobacco exposure. Using an innovative “Roll a Joint” paradigm, this study aims to (1) compare estimated and actual dose of cannabis and tobacco per joint at baseline and (2) examine the acute effects of cannabis and/or tobacco on estimated and actual dose. Materials and M...
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