H. Valerie Curran
University College London
Publications 125
#1Abigail M. Freeman (UCL: University College London)
#2Katherine Petrilli (UCL: University College London)H-Index: 1
Last.Tom P. Freeman (UCL: University College London)H-Index: 20
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Abstract The recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9-tetrahydrocannabinol (THC), but this has never been reviewed systematically. In this systematic review of how CBD influences the acute effects of THC we identified 16 studies involving 466 participants. Ten studies were judged at low risk of bias. The fin...
#1Gill Terrett (ACU: Australian Catholic University)H-Index: 7
#2Kimberly Mercuri (ACU: Australian Catholic University)H-Index: 3
Last.Peter G. Rendell (ACU: Australian Catholic University)H-Index: 30
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Background:Long-term opiate users experience pervasive social difficulties, but there has been surprisingly limited research focused on social-cognitive functioning in this population.Aim:The aim o...
#1Hina Akram (UCL: University College London)H-Index: 1
#2Claire Mokrysz (UCL: University College London)H-Index: 9
Last.H. Valerie Curran (UCL: University College London)H-Index: 41
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Background:Synthetic cannabinoids are, typically, full agonists at the cannabinoid CB1 receptor, and therefore considerably more potent than natural cannabis and may have correspondingly more serious psychological effects. Despite government sanctions against their production they continue to be available in ever-increasing varieties over the Internet. The psychological consequences of synthetic cannabinoid use are relatively unknown.Aim:The purpose of this study was to synthesise the available ...
#1Will Lawn (UCL: University College London)H-Index: 8
#2Tom P. Freeman (UCL: University College London)H-Index: 20
Last.H. Valerie Curran (UCL: University College London)H-Index: 41
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Background: Dopaminergic functioning is thought to play critical roles in both motivation and addiction. There is preliminary evidence that dopamine agonists reduce the motivation for cigarettes in smokers. However, the effects of pramipexole, a dopamine D3 receptor preferring agonist, have not been investigated. The aim of this study was to examine the effects of an acute dose of pramipexole on the motivation to earn cigarettes and nondrug rewards. Methods: Twenty dependent and 20 occasional sm...
#1Tom P. Freeman (UCL: University College London)H-Index: 20
#2Rebecca Anne Pope (UCL: University College London)H-Index: 3
Last.Michael A P Bloomfield (UCL: University College London)H-Index: 8
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Background: Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here, we investigate the effects of cannabis on listening to music, a rewarding activity that frequently occurs in the context of recreational cannabis use. We additionally tested how these effects are influenced by cannabidiol, which may offset cannabis-related harms. Methods: Across 3 sessions, 16 cannabis users inhaled cannabis with cannabidiol, cannabi...
#1Robin L. Carhart-Harris (Imperial College London)H-Index: 26
#2Leor Roseman (Imperial College London)H-Index: 11
Last.Kevin Murphy (Cardiff University)H-Index: 38
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Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD). Quality pre and post treatment fMRI data were collected from 16 of 1...
#1Chandni Hindocha (UCL: University College London)H-Index: 10
#2Will Lawn (UCL: University College London)H-Index: 8
Last.H. Valerie Curran (UCL: University College London)H-Index: 41
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Rationale Cannabis and tobacco are often smoked simultaneously in joints, and this practice may increase the risks of developing tobacco and/or cannabis use disorders. Currently, there is no human experimental research on how these drugs interact on addiction-related measures.