Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!
Begoña Indakoetxea
Instituto de Salud Carlos III
17Publications
9H-index
240Citations
Publications 17
Newest
Published on May 1, 2019in Neurobiology of Aging 4.45
Timothy Rittman18
Estimated H-index: 18
(University of Cambridge),
Robin Borchert4
Estimated H-index: 4
(University of Cambridge)
+ 122 AuthorsFabrizio Tagliavini60
Estimated H-index: 60
The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functional network resilience to preserved cognition in presymptomatic genetic frontotemporal dementia. We studied 172 people from families carrying genetic abnormalities in C9orf72, MAPT, or PGRN. Networks were extracted from functional MRI data and assessed using graph theoretical analysis. We found that despit...
1 Citations Source Cite
Published on Apr 1, 2019in NeuroImage 5.43
Enrico Premi17
Estimated H-index: 17
(University of Brescia),
Vince Daniel Calhoun87
Estimated H-index: 87
(UNM: University of New Mexico)
+ 130 AuthorsJohn VanSwieten68
Estimated H-index: 68
(EUR: Erasmus University Rotterdam)
Abstract Frontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a "chronnectome" approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 4...
Source Cite
Myriam Barandiaran7
Estimated H-index: 7
,
Fermin Moreno13
Estimated H-index: 13
+ 5 AuthorsAdolfo López de Munain33
Estimated H-index: 33
Source Cite
Published on Nov 28, 2018in Frontiers in Aging Neuroscience 3.58
Gorka Fernández-Eulate , Ainhoa Alberro2
Estimated H-index: 2
+ 19 AuthorsNora Soberón3
Estimated H-index: 3
Many factors may converge in healthy ageing in the oldest old, but their association and predictive power on healthy o functionally impaired ageing has yet to be demonstrated. By detecting healthy ageing and in turn, poor ageing, we could take action to prevent chronic diseases associated with age. We conducted a pilot study comparing results of a set of markers (peripheral blood mononuclear cell telomere length or PBMC, circulating Aβ peptides, anti-Aβ antibodies, and ApoE status) previously as...
1 Citations Source Cite
Published on Jun 8, 2017in PLOS ONE 2.77
Fermin Moreno13
Estimated H-index: 13
,
Begoña Indakoetxea9
Estimated H-index: 9
+ 10 AuthorsJosé Félix Martí Massó13
Estimated H-index: 13
1 Citations Source Cite
Published on Sep 29, 2015in Journal of Alzheimer's Disease 3.17
Pau Pastor31
Estimated H-index: 31
,
Fermin Moreno13
Estimated H-index: 13
+ 35 AuthorsEva Carro33
Estimated H-index: 33
Spanish Ministry of Science and Innovation SAF 2006-10126 (2006–2009) and SAF2010-22329-C02-01 (2011–2013) to P.P and by the UTE project FIMA to P.P. Grants from the Ministry of Science (SAF2010-15558) and CIBERNED. Agust´in Ruiz is supported by grant PI13/02434 (Accion Estrategica en Salud. Instituto de Salud Carlos III. Ministerio de Economia y Competitividad, Spain). Grant: Consolider (CSD2010-00045).
15 Citations Source Cite
Published on Nov 1, 2014in Neurobiology of Aging 4.45
Mathias Thelen4
Estimated H-index: 4
(University of Bonn),
Cristina Razquin22
Estimated H-index: 22
(University of Navarra)
+ 45 AuthorsTanja Duenkel1
Estimated H-index: 1
(Heidelberg University)
Abstract Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. Rare TREM2 variants have been recently identified in families affected by FTD-like phenotype. However, genetic studies of the role of rare TREM2 variants in FTD have generated conflicting results possibly because of difficulties on diagnostic accuracy. The aim of the present study was to investigate associations between rare TREM2 variants and specific FTD subtypes (FTD-S). The entire coding sequence o...
25 Citations Source Cite
Published on May 1, 2013in Neurobiology of Aging 4.45
Fermin Moreno13
Estimated H-index: 13
(ISCIII: Instituto de Salud Carlos III),
Roser Sala-Llonch22
Estimated H-index: 22
(University of Barcelona)
+ 9 AuthorsJosé Félix Martí Massó13
Estimated H-index: 13
(ISCIII: Instituto de Salud Carlos III)
Abstract Studies in asymptomatic granulin gene ( GRN ) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinical GRN mutation carriers and to study the relationship of CTh with cognitive performance in GRN mutation carriers. We calculated CTh maps in 13 asymptomatic carriers of t...
8 Citations Source Cite
Myriam Barandiaran7
Estimated H-index: 7
,
Ainara Estanga10
Estimated H-index: 10
+ 5 AuthorsAdolfo López de Munain33
Estimated H-index: 33
Mutations in the progranulin (PGRN) gene have been identified as a cause of frontotemporal dementia (FTD). However, little is known about the neuropsychological abilities of asymptomatic carriers of these mutations. The aim of the study was to assess cognitive functioning in asymptomatic c.709-1G>A PGRN mutation carriers. We hypothesized that poorer neuropsychological performance could be present before the development of clinically significant FTD symptoms. Thirty-two asymptomatic first-degree ...
11 Citations Source Cite
Published on Jan 1, 2011in Alzheimer Disease & Associated Disorders 1.94
Fermin Moreno13
Estimated H-index: 13
,
Ainhoa Alzualde11
Estimated H-index: 11
+ 6 AuthorsBegoña Indakoetxea9
Estimated H-index: 9
Frontotemporal lobar degeneration because of mutations in the progranulin (PGRN) gene presents a high variability both in the clinical phenotype and age of onset of disease. Factors that influence this variability remain largely unknown. The aim of our study was to determine whether selected genetic variables modify age at onset of disease in our series of 21 patients with a single splicing mutation (c.709-1G>A) in the PGRN gene, all of whom were of Basque descent. In our analysis, we included t...
9 Citations Source Cite
12