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Sarah McGrory
University of Edinburgh
20Publications
7H-index
166Citations
Publications 20
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#1Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
#2Lucia Ballerini (Edin.: University of Edinburgh)H-Index: 19
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 12 authors...
Abstract Introduction We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change. Methods Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospati...
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#1Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
#2Lucia Ballerini (Edin.: University of Edinburgh)H-Index: 19
Last.Joanna M. Wardlaw (Edin.: University of Edinburgh)H-Index: 89
view all 15 authors...
Research has suggested that the retinal vasculature may act as a surrogate marker for diseased cerebral vessels. Retinal vascular parameters were measured using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE) software in two cohorts: (i) community-dwelling older subjects of the Lothian Birth Cohort 1936 (n = 603); and (ii) patients with recent minor ischaemic stroke of the Mild Stroke Study (n = 155). Imaging markers of small vessel disease (SVD) (white matter hyper...
2 CitationsSource
#1Lucia Ballerini (Edin.: University of Edinburgh)H-Index: 19
#2Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
Last.J Wardlaw (Edin.: University of Edinburgh)H-Index: 3
view all 13 authors...
Background: The retinal and cerebral microvasculature share many morphological and physiological properties. Perivascular Spaces (PVS), also known as Virchow-Robin spaces, are visible with increasing resolution with the ongoing improvement of brain MRI technology. We investigated the associations between quantitative retinal measurements and novel computational PVS parameters in a cohort of older people in their eighth decade. Methods: We analysed data from community-dwelling individuals (n=381 ...
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#1Ratko RadakovicH-Index: 7
#2Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
Last.Sharon AbrahamsH-Index: 41
view all 10 authors...
Objective: Apathy is a prominent syndrome across neurodegenerative diseases. The Dimensional Apathy Scale (DAS) assesses three apathy subtypes—executive, emotional, and initiation—and is sensitive and valid in amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and Parkinson’s disease. This study describes the development of the brief DAS (b-DAS), which will enable apathy to be swiftly detected in the clinic. Method: 102 ALS and 102 AD patients’ previously collected data were used. Mo...
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#1Muthu Rama Krishnan Mookiah (Dund.: University of Dundee)H-Index: 1
#2Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
Last.Emanuele Trucco (Dund.: University of Dundee)H-Index: 33
view all 7 authors...
Within the general framework of consistent and reproducible morphometric measurements of the retinal vasculature in fundus images, we present a quantitative pilot study of the changes in measurements commonly used in retinal biomarker studies (e.g. caliber-related, tortuosity and fractal dimension of the vascular network) induced by centering fundus image acquisition on either the optic disc or on the macula. To our best knowledge, no such study has been reported so far. Analyzing 149 parameters...
1 CitationsSource
#1Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
#2Adele M. Taylor (Edin.: University of Edinburgh)H-Index: 9
Last.Tom MacGillivray (Edin.: University of Edinburgh)H-Index: 35
view all 13 authors...
6 CitationsSource
#1Tom MacGillivray (Edin.: University of Edinburgh)H-Index: 35
#2Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
Last.James Cameron (Edin.: University of Edinburgh)H-Index: 8
view all 4 authors...
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Sep 9, 2017 in MICCAI (Medical Image Computing and Computer-Assisted Intervention)
#1Ahmed E. Fetit (Dund.: University of Dundee)
#2Siyamalan Manivannan (Dund.: University of Dundee)H-Index: 7
Last.Emanuele Trucco (Dund.: University of Dundee)H-Index: 33
view all 12 authors...
Dementia is a devastating disease, and has severe implications on affected individuals, their family and wider society. A growing body of literature is studying the association of retinal microvasculature measurement with dementia. We present a pilot study testing the strength of groups of conventional (semantic) and texture-based (non-semantic) measurements extracted from retinal fundus camera images to classify patients with and without dementia. We performed a 500-trial bootstrap analysis wit...
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#1James CameronH-Index: 8
#2Roly MegawH-Index: 7
Last.Baljean DhillonH-Index: 34
view all 10 authors...
Abstract No biological system or structure is likely to be perfectly symmetrical, or have identical right and left forms. This review explores the evidence for eye and visual pathway asymmetry, in health and in disease, and attempts to provide guidance for those studying the structure and function of the visual system, where recognition of symmetry or asymmetry may be essential. The principal question with regards to asymmetry is not ‘are the eyes the same?’, for some degree of asymmetry is perv...
8 CitationsSource
#1Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
#2Adele M. Taylor (Edin.: University of Edinburgh)H-Index: 9
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 13 authors...
Aim To examine the relationship between retinal vascular morphology and cognitive abilities in a narrow-age cohort of community-dwelling older people. Methods Digital retinal images taken at age ∼73 years from 683 participants of the Lothian Birth Cohort 1936 (LBC1936) were analysed with Singapore I Vessel Assessment (SIVA) software. Multiple regression models were applied to determine cross-sectional associations between retinal vascular parameters and general cognitive ability ( g ), memory, p...
10 CitationsSource
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