Match!
Günter Raddatz
German Cancer Research Center
DNA methylationMethylationEpigeneticsGeneticsBiology
17Publications
11H-index
290Citations
What is this?
Publications 19
Newest
#1Florian Köhler (DKFZ: German Cancer Research Center)H-Index: 3
#2Felix Bormann (DKFZ: German Cancer Research Center)H-Index: 6
Last. Manuel Rodríguez-Paredes (DKFZ: German Cancer Research Center)H-Index: 12
view all 10 authors...
Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein lamin A (termed progerin) and have previously been shown to exhibit prominent histone modification changes. Here, we analyze the possibility that epigenetic deregulation of lamina-associated domains (LADs) is involve...
1 CitationsSource
#1L. Sole-Boldo (DKFZ: German Cancer Research Center)H-Index: 1
#1Llorenç Solé-Boldo (DKFZ: German Cancer Research Center)H-Index: 1
Last. Frank Lyko (DKFZ: German Cancer Research Center)H-Index: 52
view all 8 authors...
Fibroblasts are an essential cell population for human skin architecture and function. While fibroblast heterogeneity is well established, this phenomenon has not been analyzed systematically yet. We have used single-cell RNA sequencing to analyze the transcriptomes of more than 5,000 fibroblasts from a sun-protected area in healthy human donors. Our results define four main subpopulations that can be spatially localized and show differential secretory, mesenchymal and pro-inflammatory functiona...
2 CitationsSource
#1Ihab Ansari (HUJI: Hebrew University of Jerusalem)H-Index: 2
#2Günter Raddatz (DKFZ: German Cancer Research Center)H-Index: 11
Last. Eran Elinav (Weizmann Institute of Science)H-Index: 56
view all 12 authors...
Although much research has been done on the diversity of the gut microbiome, little is known about how it influences intestinal homeostasis under normal and pathogenic conditions. Epigenetic mechanisms have recently been suggested to operate at the interface between the microbiota and the intestinal epithelium. We performed whole-genome bisulfite sequencing on conventionally raised and germ-free mice, and discovered that exposure to commensal microbiota induced localized DNA methylation changes ...
6 CitationsSource
#1L. Sole-Boldo (DKFZ: German Cancer Research Center)H-Index: 1
#2Günter Raddatz (DKFZ: German Cancer Research Center)H-Index: 11
Last. Frank Lyko (DKFZ: German Cancer Research Center)H-Index: 52
view all 8 authors...
Summary Fibroblasts are the main dermal cell type and are essential for the architecture and function of human skin. Important differences have been described between fibroblasts localized in distinct dermal layers, and these cells are also known to perform varied functions. However, this phenomenon has not been analyzed comprehensively yet. Here we have used single-cell RNA sequencing to analyze >15,000 cells from a sun-protected area in young and old donors. Our results define four main fibrob...
4 CitationsSource
#1Laura Wiehle (DKFZ: German Cancer Research Center)H-Index: 2
#2Graeme J. Thorn (University of Essex)H-Index: 4
Last. Vladimir B. Teif (University of Essex)H-Index: 18
view all 8 authors...
Coordinated changes of DNA (de)methylation, nucleosome positioning and chromatin binding of the architectural protein CTCF play an important role for establishing cell type specific chromatin states during differentiation. To elucidate molecular mechanisms that link these processes we studied the perturbed DNA modification landscape in mouse embryonic stem cells (ESCs) carrying a double knockout (DKO) of the TET1 and TET2 dioxygenases. These enzymes are responsible for the conversion of 5-methyl...
9 CitationsSource
#1Nora Kristin Elisa Schulz (WWU: University of Münster)H-Index: 2
#2C. Isabel Wagner (WWU: University of Münster)H-Index: 1
Last. Joachim Kurtz (WWU: University of Münster)H-Index: 36
view all 7 authors...
Epigenetic mechanisms, such as CpG DNA methylation enable phenotypic plasticity and rapid adaptation to changing environments. CpG DNA methylation is established by DNA methyltransferases (DNMTs), which are well conserved across vertebrates and invertebrates. There are insects with functional DNA methylation despite lacking a complete set of Dnmts. But at least one of the enzymes, DNMT1, appears to be required to maintain an active DNA methylation system. The red flour beetle, Tribolium castaneu...
8 CitationsSource
#1Fanny Gatzmann (DKFZ: German Cancer Research Center)H-Index: 1
#2Cassandra Falckenhayn (DKFZ: German Cancer Research Center)H-Index: 1
Last. Frank Lyko (DKFZ: German Cancer Research Center)H-Index: 52
view all 7 authors...
Background The parthenogenetic marbled crayfish (Procambarus virginalis) is a novel species that has rapidly invaded and colonized various different habitats. Adaptation to different environments appears to be independent of the selection of genetic variants, but epigenetic programming of the marbled crayfish genome remains to be understood.
7 CitationsSource
#1Nora Kristin Elisa Schulz (WWU: University of Münster)H-Index: 2
#2Clara Isabel Wagner (WWU: University of Münster)
Last. Joachim Kurtz (WWU: University of Münster)H-Index: 36
view all 7 authors...
Epigenetic mechanisms, such as CpG DNA methylation enable phenotypic plasticity and rapid adaptation to changing environments. CpG DNA methylation is established by DNA methyltransferases (DNMTs), which are well conserved across vertebrates and invertebrates. There are insects with functional DNA methylation despite lacking a complete set of Dnmts. But at least one of the enzymes, DNMT1, appears to be required to maintain an active DNA methylation system. The red flour beetle, Tribolium castaneu...
Source
#1Manuel Rodríguez-Paredes (DKFZ: German Cancer Research Center)H-Index: 12
#2Felix Bormann (DKFZ: German Cancer Research Center)H-Index: 6
Last. Frank LykoH-Index: 52
view all 20 authors...
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic keratosis (AK). Despite various efforts to characterize these lesions molecularly, the etiology of AK and its progression to cSCC remain partially understood. Here, we use Infinium MethylationEPIC BeadChips to interrogate the DNA methylation status in healthy, AK and cSCC epidermis samples. Importantly, we show that AK methylation patterns alr...
11 CitationsSource
#1Laura WiehleH-Index: 2
#2Günter RaddatzH-Index: 11
Last. Frank LykoH-Index: 8
view all 7 authors...
: Isocitrate dehydrogenases 1 and 2 (IDH1/2) are recurrently mutated in acute myeloid leukemia (AML), but their mechanistic role in leukemogenesis is poorly understood. The inhibition of TET enzymes by D-2-hydroxyglutarate (D-2-HG), which is produced by mutant IDH1/2 (mIDH1/2), has been suggested to promote epigenetic deregulation during tumorigenesis. In addition, mIDH also induces a differentiation block in various cell culture and mouse models. Here we analyze the genomic methylation patterns...
1 CitationsSource
12