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Ghislaine Scelo
International Agency for Research on Cancer
132Publications
32H-index
3,367Citations
Publications 134
Newest
#1Linda Kachuri (UCSF: University of California, San Francisco)H-Index: 9
#2Mattias Johansson (IARC: International Agency for Research on Cancer)H-Index: 37
Last.Rayjean J. Hung (U of T: University of Toronto)H-Index: 46
view all 51 authors...
Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is genetically correlated with reduced forced expiratory volume in one second (FEV1: rg = 0.098, p = 2.3 × 10−8) and the ratio of FEV1 to forced vital capacity (FEV1/FVC: rg = 0.137, p =...
1 CitationsSource
#1Ruhina Shirin Laskar (IARC: International Agency for Research on Cancer)H-Index: 6
#2David C. Muller (Imperial College London)H-Index: 17
Last.Ghislaine Scelo (IARC: International Agency for Research on Cancer)H-Index: 32
view all 108 authors...
Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227 cases, 4916 controls) and women (1992 cases, 3095 controls) of European ancestry from two RCC genome-wide scans and replicated the top findings using an additional series of men (2261 cases, 5852 con...
Source
#1Tricia L LaroseH-Index: 9
#2Pål SætromH-Index: 31
Last.Martyn T. SmithH-Index: 79
view all 9 authors...
The Peder Sather Center for Advanced Study, University of California, Berkely Norwegian University of Sceince and Technology, Trondheim, Norway
Source
#1Yan Zhang (Johns Hopkins University)H-Index: 1
#2Yan Zhang (Johns Hopkins University)H-Index: 4
Last.Montserrat Garcia-ClosasH-Index: 82
view all 103 authors...
We analyzed summary-level data from genome-wide association studies (GWAS) of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) contributing to risk, as well as the distribution of their associated effect sizes. All cancers evaluated showed polygenicity, involving at a minimum thousands of independent susceptibility variants. For some malignancies, particularly chronic lymphoid leukemia (CLL) and testicular cancer, susceptibili...
1 CitationsSource
#1Fei Chen (Johns Hopkins University)H-Index: 4
#2Erica J. Childs (Johns Hopkins University)H-Index: 6
Last.Alison P. Klein (Johns Hopkins University)H-Index: 54
view all 26 authors...
Background: Pancreatic cancer is the fourth-leading cause of cancer death in both men and women in the United States. The currently identified common susceptibility loci account for a small fraction of estimated heritability. We sought to estimate overall heritability of pancreatic cancer and partition the heritability by variant frequencies and functional annotations. Methods: Analysis using the genome-based restricted maximum likelihood method (GREML) was conducted on Pancreatic Cancer Case-Co...
2 CitationsSource
#1Patrice H. Avogbe (IARC: International Agency for Research on Cancer)H-Index: 7
#2Arnaud ManelH-Index: 1
Last.Florence Le Calvez-Kelm (IARC: International Agency for Research on Cancer)H-Index: 23
view all 25 authors...
Abstract Background Recurrent mutations in the promoter of the telomerase reverse transcriptase (TERT) gene (C228T and C250T) detected in tumours and cells shed into urine of urothelial cancer (UC) patients are putative biomarkers for UC detection and monitoring. However, the possibility of detecting these mutations in cell-free circulating DNA (cfDNA) in blood and urine, or DNA from urinary exfoliated cells (cellDNA) with a single-gene sensitive assay has never been tested in a case-control set...
1 CitationsSource
#1Linda Kachuri (U of T: University of Toronto)H-Index: 9
#2Olli Saarela (U of T: University of Toronto)H-Index: 16
Last.Rayjean J. Hung (U of T: University of Toronto)H-Index: 46
view all 70 authors...
Background: Evidence from observational studies of telomere length (TL) has been conflicting regarding its direction of association with cancer risk. We investigated the causal relevance of TL for lung and head and neck cancers using Mendelian Randomization (MR) and mediation analyses. Methods: We developed a novel genetic instrument for TL in chromosome 5p15.33, using variants identified through deep-sequencing, that were genotyped in 2051 cancer-free subjects. Next, we conducted an MR analysis...
3 CitationsSource
#1Tiffany M. Delhomme (IARC: International Agency for Research on Cancer)H-Index: 3
#2Patrice H. Avogbe (IARC: International Agency for Research on Cancer)H-Index: 7
Last.Matthieu Foll (IARC: International Agency for Research on Cancer)H-Index: 27
view all 25 authors...
The emergence of Next-Generation Sequencing (NGS) has revolutionized the way of reaching a genome sequence, with the promise of potentially providing a comprehensive characterization of DNA variations. Nevertheless, detecting somatic mutations is still a difficult problem, in particular when trying to identify low abundance mutations such as subclonal mutations, tumour-derived alterations in body fluids or somatic mutations from histological normal tissue. The main challenge is to precisely dist...
1 CitationsSource
#1Linda Kachuri (UCSF: University of California, San Francisco)H-Index: 9
#2Mattias Johansson (IARC: International Agency for Research on Cancer)H-Index: 37
Last.Rayjean J. Hung (U of T: University of Toronto)H-Index: 46
view all 51 authors...
Impaired lung function is an indicator of obstructive pulmonary disease and may be a consequence of cigarette smoking, making it challenging to disentangle its role in lung cancer etiology. We investigated the shared genetic basis of pulmonary dysfunction and lung cancer susceptibility using genome-wide data from the UK Biobank (>370,000 individuals) and the International Lung Cancer Consortium (29,266 cases, 56,450 controls). We observed strong genetic correlations between lung cancer and reduc...
Source
#1Kazufumi Honda (Japan Agency for Medical Research and Development)H-Index: 29
#2Verena Katzke (DKFZ: German Cancer Research Center)H-Index: 22
Last.Rudolph Kaaks (DKFZ: German Cancer Research Center)H-Index: 118
view all 42 authors...
Recently, we identified unique processing patterns of apolipoprotein A2 (ApoA2) in patients with pancreatic cancer. Our study provides a first prospective evaluation of an ApoA2 isoform (“ApoA2-ATQ/AT”), alone and in combination with carbohydrate antigen 19–9 (CA19-9), as an early detection biomarker for pancreatic cancer. We performed ELISA measurements of CA19-9 and ApoA2-ATQ/AT in 156 patients with pancreatic cancer and 217 matched controls within the European EPIC cohort, using plasma sample...
6 CitationsSource
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