Elise G.P. Dopper
Erasmus University Rotterdam
PathologyPsychologyC9orf72Frontotemporal dementiaMedicine
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Publications 50
#1Katrina M. Moore (UCL: University College London)H-Index: 1
#2Jennifer M. Nicholas (Lond: University of London)H-Index: 20
Last. Daniel H. GeschwindH-Index: 129
view all 171 authors...
Summary Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72. Methods In this international, retrospective cohort study, we col...
2 CitationsSource
#1Sven J. van der Lee (VU: VU University Amsterdam)H-Index: 24
#2Olivia J. Conway (Mayo Clinic)H-Index: 1
Last. Jason A. Chen (UCLA: University of California, Los Angeles)H-Index: 11
view all 259 authors...
The IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once.
#1Rogier A. Feis (University of Oxford)
#2Mark J.R.J. Bouts (LEI: Leiden University)H-Index: 9
Last. Serge A.R.B. Rombouts (LEI: Leiden University)H-Index: 68
view all 11 authors...
Frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However, it is unknown at what disease stage these differences emerge. Here, we investigate whether divergent differences in grey matter volume, white matter diffusion, and functional connectivity are already apparent between cognitively healthy carriers of pathogenic FTD mutations, and cognitively healthy carriers at inc...
#1Emma L. van der Ende (EUR: Erasmus University Rotterdam)H-Index: 4
#2Lieke H.H. Meeter (EUR: Erasmus University Rotterdam)H-Index: 8
Last. John C. van Swieten (EUR: Erasmus University Rotterdam)H-Index: 53
view all 43 authors...
Summary Background Neurofilament light chain (NfL) is a promising blood biomarker in genetic frontotemporal dementia, with elevated concentrations in symptomatic carriers of mutations in GRN, C9orf72, and MAPT. A better understanding of NfL dynamics is essential for upcoming therapeutic trials. We aimed to study longitudinal NfL trajectories in people with presymptomatic and symptomatic genetic frontotemporal dementia. Methods We recruited participants from 14 centres collaborating in the Geneti...
3 CitationsSource
#1Jessica L. Panman (LUMC: Leiden University Medical Center)
#2Yang Yang To (Erasmus University Medical Center)
Last. Anne Hafkemeijer (LEI: Leiden University)H-Index: 13
view all 14 authors...
textabstractNeuroimaging MRI data in scientific research is increasingly pooled, but the reliability of such studies may be hampered by the use of different hardware elements. This might introduce bias, for example when cross-sectional studies pool data acquired with different head coils, or when longitudinal clinical studies change head coils halfway. In the present study, we aimed to estimate this possible bias introduced by using different head coils to create awareness and to avoid misinterp...
Background Multimodal MRI-based classification may aid early frontotemporal dementia (FTD) diagnosis. Recently, presymptomatic FTD mutation carriers, who have a high risk of developing FTD, were separated beyond chance level from controls using MRI-based classification. However, it is currently unknown how these scores from classification models progress as mutation carriers approach symptom onset. In this longitudinal study, we investigated multimodal MRI-based classification scores between pre...
#1Jessica L. Panman (EUR: Erasmus University Rotterdam)H-Index: 5
#2Lize C. Jiskoot (EUR: Erasmus University Rotterdam)H-Index: 9
Last. Janne M. Papma (EUR: Erasmus University Rotterdam)H-Index: 9
view all 13 authors...
Abstract In genetic frontotemporal dementia, cross-sectional studies have identified profiles of presymptomatic neuroanatomical loss for C9orf72 repeat expansion, MAPT, and GRN mutations. In this study, we characterize longitudinal gray matter (GM) and white matter (WM) brain changes in presymptomatic frontotemporal dementia. We included healthy carriers of C9orf72 repeat expansion (n = 12), MAPT (n = 15), GRN (n = 33) mutations, and related noncarriers (n = 53), that underwent magnetic resonanc...
4 CitationsSource
#1Rogier A. FeisH-Index: 3
#2Mark J.R.J. BoutsH-Index: 9
Last. Serge A.R.B. RomboutsH-Index: 68
view all 10 authors...
#1Lize C. Jiskoot (EUR: Erasmus University Rotterdam)H-Index: 9
#2Jessica L. Panman (EUR: Erasmus University Rotterdam)H-Index: 5
Last. John VanSwieten (EUR: Erasmus University Rotterdam)H-Index: 71
view all 11 authors...
Developing and validating sensitive biomarkers for the presymptomatic stage of familial frontotemporal dementia is an important step in early diagnosis and for the design of future therapeutic trials. In the longitudinal Frontotemporal Dementia Risk Cohort, presymptomatic mutation carriers and non-carriers from families with familial frontotemporal dementia due to microtubule-associated protein tau (MAPT) and progranulin (GRN) mutations underwent a clinical assessment and multimodal MRI at basel...
9 CitationsSource
#1Lize C. Jiskoot (UCL: University College London)H-Index: 9
#2Martina Bocchetta (UCL: University College London)H-Index: 22
Last. Jonathan D. Rohrer (EUR: Erasmus University Rotterdam)H-Index: 50
view all 30 authors...
Objective: We aimed to investigate mutation-specific white matter (WM) integrity changes in presymptomatic and symptomatic mutation carriers of the C9orf72, MAPT, and GRN mutations by use of diffusion-weighted imaging within the Genetic Frontotemporal dementia Initiative (GENFI) study. Methods: One hundred and forty mutation carriers (54 C9orf72, 30 MAPT, 56 GRN), 104 presymptomatic and 36 symptomatic, and 115 noncarriers underwent 3T diffusion tensor imaging. Linear mixed effects models were us...
8 CitationsSource