Katja Mühlberg
Leipzig University
Publications 3
#1Tewodros Debebe (Leipzig University)H-Index: 5
#2Monika Krüger (Leipzig University)H-Index: 16
Last.Gerd Birkenmeier (Leipzig University)H-Index: 24
view all 7 authors...
The microbiota has a strong influence on health and disease in humans. A causative shift favoring pathobionts is strongly linked to diseases. Therefore, anti-microbial agents selectively targeting potential pathogens as well as their biofilms are urgently demanded. Here we demonstrate the impact of ethyl pyruvate, so far known as ROS scavenger and anti-inflammatory agent, on planktonic microbes and biofilms. Ethyl pyruvate combats preferably the growth of pathobionts belonging to bacteria and fu...
5 CitationsSource
#1Beate Jaekel (Leipzig University)H-Index: 1
#2Katja Mühlberg (Leipzig University)H-Index: 2
Last.Clemens Allgaier (Leipzig University)H-Index: 21
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Exposure of cultured cortical neurons to elevated extracellular K+ concentrations (25 mM) induces membrane depolarization and an increase in action-potential firing. Long-term high K+ treatment was associated with an increased neuronal cell death. In surviving neurons, multiple changes occurred in the proportion of individual NMDA receptor subunit 1 (NR1) splice variant mRNA expression, whereas the overall expression of NR1, NR2A and NR2B transcripts remained unaffected. The high K+-induced chan...
12 CitationsSource