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John D. Sandy
Rush University Medical Center
Molecular biologyAggrecanProteoglycanCartilageBiology
135Publications
49H-index
8,561Citations
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Publications 139
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#2Jinnan Chen (Rush University)
Last. Vincent M. WangH-Index: 26
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#1Mary Clare McCorry (Cornell University)H-Index: 4
#2Jongkil Kim (Cornell University)H-Index: 1
Last. Lawrence J. Bonassar (Cornell University)H-Index: 58
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Abstract Fibrillar collagens are highly prevalent in the extracellular matrix of all connective tissues and therefore commonly used as a biomaterial in tissue engineering applications. In the native environment, collagen fibers are arranged in a complex hierarchical structure that is often difficult to recreate in a tissue engineered construct. Small leucine rich proteoglycans as well as hyaluronan binding proteoglycans, aggrecan and versican, have been implicated in regulating fiber formation. ...
1 CitationsSource
#1Katie J. SikesH-Index: 2
#2Kristen RennerH-Index: 2
Last. Vincent M. WangH-Index: 26
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2 CitationsSource
#1Katie J. Sikes (UIC: University of Illinois at Chicago)H-Index: 2
#2Jun Li (Rush University Medical Center)H-Index: 18
Last. Vincent M. Wang (UIC: University of Illinois at Chicago)H-Index: 26
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ABSTRACTPurpose/Aim of the study: Healthy tendons are maintained in homeostasis through controlled usage of glucose for energy and redox equilibrium. Tendon cell stress imposed by overuse injury or...
2 CitationsSource
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#1Katie J. Trella (UIC: University of Illinois at Chicago)H-Index: 3
#2Jun Li (Rush University Medical Center)H-Index: 18
Last. Robert W. Wysocki (Rush University Medical Center)H-Index: 28
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We have used a murine Achilles tendinopathy model to investigate whether tissue changes (such as collagen disorganization, chondroid metaplasia, and loss of tensile properties) which are broadly characteristic of human tendinopathies, are accompanied by changes in the expression of chromatin-modifying enzymes and the methylation status of promoter regions of tendon cell DNA. Tendinopathy was induced by two intra-tendinous TGF-β1 injections followed by cage activity or treadmill running for up to...
7 CitationsSource
The superficial layers (surface and sub-surface) of human articular cartilage represent specialized joint tissues with cellular and matrix compositions different to the deeper layers. The distinct properties of the superficial layers confer specialized functions and also provide a frontline barrier to degenerative insult (cellular, soluble, biomechanical) from the joint space. The design of interventions to protect/regenerate the superficial layers in the earliest stages of joint pathology will ...
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#1Wei Luo (Rush University Medical Center)H-Index: 1
#2John D. Sandy (Rush University Medical Center)H-Index: 49
Last. Anna Plaas (Rush University Medical Center)H-Index: 41
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Equine degenerative suspensory ligament desmitis (DSLD) in Peruvian Paso horses typically presents at 7–15 years and is characterized by lameness, focal disorganization of collagen fibrils, and chondroid deposition in the body of the ligament. With the aim of developing a test for disease risk (that can be used to screen horses before breeding) we have quantified the expression of 76 TGFβ-signaling target genes in adipose-derived stromal fibroblasts (ADSCs) from six DSLD-affected and five unaffe...
5 CitationsSource
#1John D. Sandy (Rush University Medical Center)H-Index: 49
#2Deva D. Chan (Rush University Medical Center)H-Index: 12
Last. Anna Plaas (Rush University Medical Center)H-Index: 41
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Summary A major objective of this article is to examine the research implications of recently available genome-wide expression profiles of cartilage from human osteoarthritis (OA) joints. We propose that, when viewed in the light of extensive earlier work, this novel data provides a unique opportunity to reorient the design of experimental systems toward clinical relevance. Specifically, in the area of cartilage explant biology, this will require a fresh evaluation of existing paradigms, so as t...
20 CitationsSource
#1Deva D. Chan (Rush University Medical Center)H-Index: 12
#2W.F. Xiao (CSU: Central South University)H-Index: 1
Last. Anna Plaas (Rush University Medical Center)H-Index: 41
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Summary Objective Articular cartilage defects commonly result from traumatic injury and predispose to degenerative joint diseases. To test the hypothesis that aberrant healing responses and chronic inflammation lead to osteoarthritis (OA), we examined spatiotemporal changes in joint tissues after cartilage injury in murine knees. Since intra-articular injection of hyaluronan (HA) can attenuate injury-induced osteoarthritis in wild-type (WT) mice, we investigated a role for HA in the response to ...
15 CitationsSource
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