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Kathryn L. Gatford
University of Adelaide
EndocrinologyFetusPregnancyDiabetes mellitusBiology
101Publications
23H-index
1,769Citations
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Publications 100
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#1Kathryn L. Gatford (University of Adelaide)H-Index: 23
#2Prabha H. Andraweera (University of Adelaide)H-Index: 9
Last. Alison S. Care (University of Adelaide)H-Index: 12
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Preeclampsia is a common pregnancy complication, affecting 2% to 8% of pregnancies worldwide, and is an important cause of both maternal and fetal morbidity and mortality. Importantly, although aspirin and calcium are able to prevent preeclampsia in some women, there is no cure apart from delivery of the placenta and fetus, often necessitating iatrogenic preterm birth. Preclinical models of preeclampsia are widely used to investigate the causes and consequences of preeclampsia and to evaluate sa...
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#1Harleen Kaur (University of Adelaide)
#2Beverly S. Muhlhausler (University of Adelaide)H-Index: 36
Last. Johannes D. Veldhuis (Mayo Clinic)H-Index: 90
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Circulating growth hormone (GH) concentrations increase during pregnancy in mice and remain pituitary-derived. Whether abundance or activation of the GH secretagogue, ghrelin increase during pregnancy or in response to dietary octanoic acid supplementation are unclear. We therefore measured circulating GH profiles in late pregnant C57BL/6J mice and in aged-matched non-pregnant females, fed standard laboratory chow supplemented with 5% octanoic or palmitic (control) acid (n=4-13/group). Serum tot...
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#1Prabha H. Andraweera (University of Adelaide)H-Index: 9
#2Kathryn L. Gatford (University of Adelaide)H-Index: 23
Last. Claire T. Roberts (University of Adelaide)H-Index: 42
view all 8 authors...
Preeclampsia (PE) is now recognised as a cardiovascular risk factor for women. Emerging evidence suggests that children exposed to PE in utero may also be at increased risk of cardiovascular disease (CVD) in later life. Individuals exposed to PE in utero have higher systolic and diastolic blood pressure and higher body mass index (BMI) compared to those not exposed to PE in utero. The aim of this review is to discuss the potential mechanisms driving the relationship between PE and offspring CVD....
3 CitationsSource
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#1Amy L. Wooldridge (University of Adelaide)H-Index: 6
#2Mark McMillan (University of Adelaide)H-Index: 10
Last. Kathryn L. Gatford (University of Adelaide)H-Index: 23
view all 6 authors...
Background Individual susceptibility to allergic diseases is developmentally programmed by early-life exposures. Evidence from preclinical studies suggests that intrauterine growth restriction is protective against later inflammatory responses to allergens. Objective We sought to evaluate whether prenatal growth affects susceptibility to allergy in human subjects. Methods We systematically searched for relevant studies in 11 databases, including Web of Science, ProQuest, EMBASE, and PubMed. We i...
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#1Vicki L. Clifton (Translational Research Institute)H-Index: 42
#2Megan McDonald (Translational Research Institute)
Last. Timothy J. M. Moss (Monash University, Clayton campus)H-Index: 46
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Abstract Maternal asthma increases the risk of adverse pregnancy outcomes and may affect fetal growth and placental function by differential effects on the expression of glucocorticoid receptor (GR) isoforms, leading to altered glucocorticoid signalling. Our aim was to examine the effect of maternal asthma on placental GR profiles using a pregnant sheep model of asthma. Nine known GR isoforms were detected. There was a significant increase in the expression of placental GR isoforms that are know...
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#1Amy L. Wooldridge (University of Adelaide)H-Index: 6
#2Vicki L. Clifton (University of Adelaide)H-Index: 42
Last. Kathryn L. Gatford (University of Adelaide)H-Index: 23
view all 12 authors...
Experimental maternal allergic asthma in sheep provides an experimental model in which to test impacts on progeny Fetuses from allergic asthmatic ewes had fewer surfactant-producing cells in lungs A greater proportion of lymphocytes from thymus were CD44 positive in fetuses from allergic asthmatic ewes than controls These changes to fetal development might contribute to poor neonatal lung function and increased risk of allergy seen in offspring of pregnancies complicated by asthma ABSTRACT: Asth...
4 CitationsSource
#1Tamara J. Varcoe (UniSA: University of South Australia)H-Index: 16
#2Jack R. T. Darby (UniSA: University of South Australia)H-Index: 6
Last. Janna L. Morrison (UniSA: University of South Australia)H-Index: 35
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6 CitationsSource
#1Dane M. Horton (University of Adelaide)H-Index: 2
#2David A. Saint (University of Adelaide)H-Index: 32
Last. Julie A. Owens (University of Adelaide)H-Index: 52
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Intrauterine growth restriction (IUGR) and subsequent neonatal catch-up growth are implicated in programming of insulin resistance later in life. Spontaneous IUGR in the guinea pig, due to natural ...
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#1Kathryn L. Gatford (University of Adelaide)H-Index: 23
#2David J. Kennaway (University of Adelaide)H-Index: 40
Last. Tamara J. Varcoe (University of Adelaide)H-Index: 16
view all 6 authors...
Kathryn L. Gatford, David J. Kennaway, Hong Liu, David O. Kleemann, Timothy R Kuchel, Tamara J. Varcoe
4 CitationsSource
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