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Eresha Mendis
University of Peradeniya
38Publications
19H-index
3,063Citations
Publications 36
Newest
#1V. Rizliya (University of Peradeniya)H-Index: 1
#2Eresha Mendis (University of Peradeniya)H-Index: 19
In the recent past, there has been an increasing demand for fish oil in the pharmaceutical industry, due to the findings of the health benefits provided by omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Fish oils are unique in the variety of fatty acids of which they are composed, and are an excellent source of the highly unsaturated C20 and C22 omega-3 fatty acids of medical interest. In the past, fish oil was mainly used as an important ingredient i...
7 CitationsSource
#1Eresha Mendis (University of Peradeniya)H-Index: 19
#2Se-Kwon Kim (Pukyong National University)H-Index: 85
Abstract There has been a combined effort among scientists to explore and utilize varying food sources to develop functional foods to cater the ever-increasing demand from the consumers, who seek health-promoting roles of dietary compounds. Considering the diversity of biochemicals in seaweeds that are capable of exerting bioactivities, a growing trend is developing across globe to employ seaweeds in functional food development. Proteins, peptides, amino acids, polysaccharides, phenolics, lipids...
29 CitationsSource
#1Young-Sook Cho (Pukyong National University)H-Index: 11
#2Won-Kyo Jung (Chosun University)H-Index: 42
Last.Se-Kwon Kim (Pukyong National University)H-Index: 85
view all 5 authors...
Abstract A visceral excitatory neuropeptide with a molecular weight of 1563 Da was isolated from the brain extracts of cloudy dogfish ( Scyliorhinus torazame ) discarded as a fishery by-product. Fish hindgut was employed to carry out physiological assay for its visceral excitation. During consecutive purification using C18 cartridge and high-performance liquid chromatography (HPLC), a neuropeptide (DF-2) was isolated from neuronal cell extracts of dogfish brain tissue and clearly exhibited poten...
1 CitationsSource
#1Moon-Moo Kim (Dong-eui University)H-Index: 20
#2Eresha Mendis (University of Peradeniya)H-Index: 19
Last.Se-Kwon Kim (Pukyong National University)H-Index: 85
view all 5 authors...
Marine sponges have been known to provide a source of novel bone and cartilage replacements because of their secondary metabolites and specific skeleton structures. In particular, it has been reported that spongin as a component of fibrous skeleton, pseudokeratin, neurokeratin, horny protein, and collagen-like protein in sponges can be used in several biomedical applications including osteoarthritis (OA). However, the pharmacological mechanism of action of spongin remains obscure. In this study,...
17 CitationsSource
#1Eresha Mendis (University of Peradeniya)H-Index: 19
#2Moon-Moo Kim (Dong-eui University)H-Index: 20
Last.Se-Kwon Kim (Pukyong National University)H-Index: 85
view all 4 authors...
A number of recent researches have demonstrated the therapeutic effects of glucosamine (Glc) in a range of human diseases including arthritis. For the first time, we identified that a novel Glc derivative having quaternized amino functionality (QAGlc) suppresses MMP-9 and MMP-2, gelatinases in HT1080, human fibrosarcoma cells at 40 μg/ml, following stimulation with PMA. Reporter gene assay results revealed that, the mechanism of suppression involves decreased transcriptional activation of MMP-9 ...
18 CitationsSource
#1Eresha Mendis (University of Peradeniya)H-Index: 19
#2Moon-Moo Kim (Dong-eui University)H-Index: 20
Last.Se-Kwon Kim (Pukyong National University)H-Index: 85
view all 4 authors...
Abstract Exposure of macrophages to bacterial lipopolysaccharide (LPS) induces release of proinflammatory cytokines that play crucial roles in chronic inflammation. Glucosamine has reported to possess anti-inflammatory properties and currently is the oral supplement of choice for the management of inflammation related complications including osteoarthritis. In this study, quaternized amino glucosamine (QAGlc), a newly synthesized cationic glucosamine (Glc) derivative was found to inhibit LPS-sti...
19 CitationsSource
#1Moon-Moo KimH-Index: 13
#2Eresha MendisH-Index: 19
Last.Se-Kwon KimH-Index: 85
view all 3 authors...
ABSTRACT Laurinterol is a marine sesquiterpene that has been known to have antimicrobial activity. The purpose of this study is to investigate the effect of Laurencia okamurai extract containing laurinterol (LOEL) on induction of apoptosis in melanoma cells (B16F1). Anticancer activity of LOEL against melanoma cells was shown in a dose-dependent manner by the 1-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. It was for the first time found that LOEL exhibited an excellent e...
11 CitationsSource
#1Niranjan RajapakseH-Index: 19
#2Moon-Moo Kim (Dong-eui University)H-Index: 20
Last.Se-Kwon Kim (Pukyong National University)H-Index: 85
view all 4 authors...
Glucosamine (GlcN) has been reported to possess several biomedical properties, and currently a great deal of attention has been focused on improving the functional properties of GlcN for different applications. Therefore, this study was conducted to introduce a carboxybutyryl functional group to GlcN and to find out the inhibitory mechanism of a novel GlcN derivative, carboxybutyrylated GlcN (CGlcN), on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in bact...
92 CitationsSource
#1Eresha Mendis (Pukyong National University)H-Index: 19
#2Moon-Moo Kim (Dong-eui University)H-Index: 20
Last.Se-Kwon Kim (Pukyong National University)H-Index: 85
view all 4 authors...
Abstract Although, several effects of glucosamine and its sulfated form (sulfated glucosamine) have been proposed for the suppression of osteoarthritis, their exact mechanisms have not been completely elucidated. This study explains the novel possibility of involvement of sulfated glucosamine in improving cellular antioxidant potential and thereby controlling oxidative damage that could be effective for its therapeutic potential in osteoarthritis. Treatment with sulfated glucosamine to human cho...
24 CitationsSource
#1Fereidoon ShahidiH-Index: 98
#2Eresha MendisH-Index: 19
Last.Se-Kwon KimH-Index: 85
view all 3 authors...
12 CitationsSource
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