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Maria Alieva
Utrecht University
8Publications
3H-index
43Citations
Publications 8
Newest
Published on Feb 14, 2019in Scientific Reports 4.01
Maria Alieva3
Estimated H-index: 3
(UU: Utrecht University),
Verena Leidgens4
Estimated H-index: 4
(UU: Utrecht University)
+ 3 AuthorsJacco van Rheenen (UU: Utrecht University)
The pathogenesis of glioblastoma (GBM) is characterized by highly invasive behavior allowing dissemination and progression. A conclusive image of the invasive process is not available. The aim of this work was to study invasion dynamics in GBM using an innovative in vivo imaging approach. Primary brain tumor initiating cell lines from IDH-wild type GBM stably expressing H2B-Dendra2 were implanted orthotopically in the brains of SCID mice. Using high-resolution time-lapse intravital imaging, tumo...
Published on Apr 1, 2018in Clinical & Experimental Metastasis 2.51
Maria Alieva3
Estimated H-index: 3
,
Jacco van Rheenen31
Estimated H-index: 31
(NKI-AVL: Netherlands Cancer Institute),
Marike L. D. Broekman16
Estimated H-index: 16
(UU: Utrecht University)
Surgical procedures such as tumor resection and biopsy are still the gold standard for diagnosis and (determination of) treatment of solid tumors, and are prognostically beneficial for patients. However, growing evidence suggests that even a minor surgical trauma can influence several (patho) physiological processes that might promote postoperative metastatic spread and tumor recurrence. Local effects include tumor seeding and a wound healing response that can promote tumor cell migration, proli...
Published on Dec 1, 2017in Scientific Reports 4.01
Maria Alieva3
Estimated H-index: 3
(UU: Utrecht University),
Andreia S Margarido1
Estimated H-index: 1
(UU: Utrecht University)
+ 7 AuthorsJacco van Rheenen31
Estimated H-index: 31
(UU: Utrecht University)
Although biopsies and tumor resection are prognostically beneficial for glioblastomas (GBM), potential negative effects have also been suggested. Here, using retrospective study of patients and intravital imaging of mice, we identify some of these negative aspects, including stimulation of proliferation and migration of non-resected tumor cells, and provide a strategy to prevent these adverse effects. By repeated high-resolution intravital microscopy, we show that biopsy-like injury in GBM induc...
Published on Nov 6, 2017in Neuro-oncology 10.09
Verena Leidgens4
Estimated H-index: 4
,
Maria Alieva3
Estimated H-index: 3
+ 7 AuthorsPeter Hau34
Estimated H-index: 34
Published on May 1, 2017in Neuro-oncology 10.09
Verena Leidgens , Maria Alieva3
Estimated H-index: 3
+ 7 AuthorsPeter Hau34
Estimated H-index: 34
Published on Dec 1, 2015in Imaging
Maria Alieva3
Estimated H-index: 3
,
Burcin Colak1
Estimated H-index: 1
+ 1 AuthorsJacco van Rheenen31
Estimated H-index: 31
Published on May 1, 2014
Maria Alieva3
Estimated H-index: 3
,
Laila Ritsma17
Estimated H-index: 17
(Harvard University)
+ 2 AuthorsJacco van Rheenen31
Estimated H-index: 31
Intravital microscopy is increasingly used to visualize and quantitate dynamic biological processes at the (sub)cellular level in live animals. By visualizing tissues through imaging windows, individual cells (e.g., cancer, host, or stem cells) can be tracked and studied over a time-span of days to months. Several imaging windows have been developed to access tissues including the brain, superficial fascia, mammary glands, liver, kidney, pancreas, and small intestine among others. Here, we revie...
1