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Maria Alieva
Utrecht University
7Publications
3H-index
65Citations
Publications 7
Newest
#1Maria Alieva (UU: Utrecht University)H-Index: 3
#2Verena Leidgens (UU: Utrecht University)H-Index: 4
Last.Jacco van Rheenen (UU: Utrecht University)H-Index: 33
view all 6 authors...
The pathogenesis of glioblastoma (GBM) is characterized by highly invasive behavior allowing dissemination and progression. A conclusive image of the invasive process is not available. The aim of this work was to study invasion dynamics in GBM using an innovative in vivo imaging approach. Primary brain tumor initiating cell lines from IDH-wild type GBM stably expressing H2B-Dendra2 were implanted orthotopically in the brains of SCID mice. Using high-resolution time-lapse intravital imaging, tumo...
2 CitationsSource
#1Maria AlievaH-Index: 3
#2Jacco van Rheenen (NKI-AVL: Netherlands Cancer Institute)H-Index: 33
Last.Marike L. D. Broekman (UU: Utrecht University)H-Index: 13
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Surgical procedures such as tumor resection and biopsy are still the gold standard for diagnosis and (determination of) treatment of solid tumors, and are prognostically beneficial for patients. However, growing evidence suggests that even a minor surgical trauma can influence several (patho) physiological processes that might promote postoperative metastatic spread and tumor recurrence. Local effects include tumor seeding and a wound healing response that can promote tumor cell migration, proli...
10 CitationsSource
#1Maria Alieva (UU: Utrecht University)H-Index: 3
#2Andreia S. Margarido (UU: Utrecht University)H-Index: 1
Last.Jacco van Rheenen (UU: Utrecht University)H-Index: 33
view all 10 authors...
Although biopsies and tumor resection are prognostically beneficial for glioblastomas (GBM), potential negative effects have also been suggested. Here, using retrospective study of patients and intravital imaging of mice, we identify some of these negative aspects, including stimulation of proliferation and migration of non-resected tumor cells, and provide a strategy to prevent these adverse effects. By repeated high-resolution intravital microscopy, we show that biopsy-like injury in GBM induc...
9 CitationsSource
#1Verena LeidgensH-Index: 4
#2Maria AlievaH-Index: 3
Last.Peter HauH-Index: 35
view all 10 authors...
Source
#1Verena LeidgensH-Index: 4
#2Maria AlievaH-Index: 3
Last.Peter HauH-Index: 35
view all 10 authors...
Source
#1Maria AlievaH-Index: 3
#2Burcin ColakH-Index: 1
Last.Jacco van RheenenH-Index: 33
view all 4 authors...
Source
#1Maria AlievaH-Index: 3
#2Laila Ritsma (Harvard University)H-Index: 17
Last.Jacco van RheenenH-Index: 33
view all 5 authors...
Intravital microscopy is increasingly used to visualize and quantitate dynamic biological processes at the (sub)cellular level in live animals. By visualizing tissues through imaging windows, individual cells (e.g., cancer, host, or stem cells) can be tracked and studied over a time-span of days to months. Several imaging windows have been developed to access tissues including the brain, superficial fascia, mammary glands, liver, kidney, pancreas, and small intestine among others. Here, we revie...
44 CitationsSource
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