Cristina Legido-Quigley
King's College London
Analytical chemistryChemistryDiseaseChromatographyBiomarker (medicine)
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Publications 121
#1Jodie Lord ('KCL': King's College London)
#2Bradley Jermy ('KCL': King's College London)
Last. Petra Proitsi ('KCL': King's College London)H-Index: 9
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There are currently no disease modifying treatments for Alzheimers Disease (AD). Epidemiological studies have highlighted blood metabolites as potential biomarkers, but possible confounding and reverse causation prevent causal conclusions. Here, we investigated whether nineteen metabolites previously associated with midlife cognitive function, are on the causal pathway to AD. Summary statistics from the largest Genome-Wide Association Studies (GWAS) for AD and for metabolites were used to perfor...
#1Jin Xu ('KCL': King's College London)H-Index: 3
#2Giulia Bankov ('KCL': King's College London)
Last. Latha Velayudhan ('KCL': King's College London)H-Index: 15
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INTRODUCTION: There is an urgent need to understand the molecular mechanisms underlying Alzheimer9s Disease (AD) to enable early diagnosis and develop effective treatments. Here we aim to investigate Alzheimer9s dementia using an unsupervised lipid, protein and gene multi-omic integrative approach. METHODS: A lipidomics dataset (185 AD, 40 MCI and 185 controls) and a proteomics dataset (201 AD patients, 104 MCI individuals and 97 controls) were utilised for weighted gene co-expression network an...
#1Tommi Suvitaival (Steno Diabetes Center)H-Index: 6
#2Cristina Legido-Quigley (Steno Diabetes Center)H-Index: 24
Lipidomics is one of the fastest-growing areas of molecular profiling in medicine. While increasing amounts of lipidomics data are generated, tools for analyzing and interpreting these data are not equally widely available. We present the lipidomeR -- a tool specifically designed for systematic interpretation of large lipidome-wide studies. The lipidomeR binds together statistical analysis and high-dimensional visualization, providing a reproducible pipeline for rapid interpretation of the lipid...
The current shortage of livers for transplantation has increased the use of marginal organs sourced from donation after circulatory death (DCD). However, these organs have a higher incidence of graft failure, and pre-transplant biomarkers which predict graft function and survival remain limited. Here, we aimed to find biomarkers of liver function before transplantation to allow better clinical evaluation. Matched pre- and post-transplant liver biopsies from DCD (n = 24) and donation after brain ...
#1Tibor V. Varga (UCPH: University of Copenhagen)H-Index: 21
#2Ashfaq Ali (Steno Diabetes Center)H-Index: 11
Last. Åsa Tornberg (Lund University)H-Index: 9
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We assessed whether blood lipid metabolites and their changes associate with various cardiometabolic, endocrine, bone- and energy-related comorbidities of Relative Energy Deficiency in Sport (RED-S) in female elite endurance athletes. Thirty-eight Scandinavian female elite athletes underwent a day-long exercise test. Five blood samples were obtained during the day - at fasting state and before and after two standardized exercise tests. Clinical biomarkers were assessed at fasting state, while un...
#1Uma V. Mahajan (NIH: National Institutes of Health)H-Index: 1
#1Uma V. Mahajan (NIH: National Institutes of Health)
Last. Richard O'Brien (Duke University)H-Index: 52
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Background There is growing evidence that Alzheimer disease (AD) is a pervasive metabolic disorder with dysregulation in multiple biochemical pathways underlying its pathogenesis. Understanding how perturbations in metabolism are related to AD is critical to identifying novel targets for disease-modifying therapies. In this study, we test whether AD pathogenesis is associated with dysregulation in brain transmethylation and polyamine pathways. Methods and findings We first performed targeted and...
1 CitationsSource
#1Kajetan Trošt (Steno Diabetes Center)H-Index: 1
#2Linda Ahonen (Steno Diabetes Center)H-Index: 6
Last. Torben Hansen (UCPH: University of Copenhagen)H-Index: 42
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The chemical composition of feces plays an important role in human metabolism. Metabolomics and lipidomics are valuable tools for screening the metabolite composition in feces. Here we set out to describe fecal metabolite composition in healthy participants in frozen stools. Frozen stool samples were collected from 10 healthy volunteers and cryogenically drilled in four areas along the specimen. Polar metabolites were analyzed using derivatization followed by two-dimensional gas chromatography a...
1 CitationsSource
#1Naba H. Al-SariH-Index: 1
#2Tommi SuvitaivalH-Index: 6
Last. Cristina Legido-QuigleyH-Index: 24
view all 10 authors...
Background and aims: Adipose tissue plays a pivotal role in storing excess fat and its composition reflects the history of person's lifestyle and metabolic health. Broad profiling of lipids with mass spectrometry has potential for uncovering new knowledge on the pathology of obesity, metabolic syndrome, diabetes and other related conditions. Here, we developed a lipidomic method for analyzing human subcutaneous adipose biopsies. We applied the method to four body areas to understand the differen...
1 CitationsSource
#1Sarah Westwood (University of Oxford)H-Index: 6
#2Alison L. Baird (University of Oxford)H-Index: 8
Last. Isabelle Bos (UM: Maastricht University)H-Index: 4
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We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease ...
#1Nete TofteH-Index: 2
#2Tommi SuvitaivalH-Index: 6
Last. Peter RossingH-Index: 71
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Background: Improved understanding of the pathophysiology causing diabetic kidney disease (DKD) is imperative. The aim of this study was to uncover associations between serum metabolites and renal outcomes. Methods: Non-targeted serum metabolomics analyses were performed in samples from 637 persons with type 1 diabetes using two-dimensional gas chromatography coupled to time-of-flight mass-spectrometry. Longitudinal data at follow-up (median 5.5 years) on renal events were obtained from national...
1 CitationsSource