Sonia Caprio
Yale University
EndocrinologyInsulin resistanceInsulinDiabetes mellitusMedicine
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Publications 265
#1Michelle A. Van Name (Yale University)H-Index: 10
#2Mary Savoye (Yale University)H-Index: 27
Last. Pamela L. Valentino (Yale University)H-Index: 7
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BACKGROUND Recent literature suggests that the Western diet's imbalance between high ω-6 (n-6) and low ω-3 (n-3) PUFA intake contributes to fatty liver disease in obese youth. OBJECTIVES We tested whether 12 wk of a low n-6:n-3 PUFA ratio (4:1) normocaloric diet mitigates fatty liver and whether the patatin-like containing domain phospholipase 3 (PNPLA3) rs738409 variant affects the response. METHODS In a single-arm unblinded study, obese youth 9-19 y of age with nonalcoholic fatty liver disease...
#1Alfonso GalderisiH-Index: 10
#2Stephanie SamuelsH-Index: 1
Last. Sonia CaprioH-Index: 65
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#1Silva A. ArslanianH-Index: 65
#2Laure El ghormliH-Index: 15
Last. Steven E. KahnH-Index: 101
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#1David A. EhrmannH-Index: 49
#2Sharon L. EdelsteinH-Index: 39
Last. Steven E. KahnH-Index: 101
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The RISE Consortium conducted a study in adults with IGT or recently diagnosed T2D to determine if β-cell function can be conserved or improved. Participants were randomized to GB, metformin, liraglutide + metformin (L+M), or placebo. β-cell function was assessed at baseline (BAS) and at 12 mo (12M) on therapy. Hyperglycemic clamp measures of β-cell function were: acute C-peptide (CP) response to glucose (ACPRg), steady-state CP (SSCP) at a plasma glucose of 11.1 mmol/L and maximal CP response t...
#2Jessica LeventhalH-Index: 1
Last. William V. TamborlaneH-Index: 87
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GLP-1 analogues (GLP-1a) may change sweet food preferences but the neural mechanisms are not fully understood. We studied the effect of GLP-1a on neural responses to drinking high fructose corn syrup (HFCS) using fMRI in 5 lean (LN, BMI 21kg/m2, mean age 21, A1c 5.3%) and 7 obese (OB, BMI 38, age 26, A1c 5.5%) subjects. The OB group had a second fMRI after 3-mos treatment with liraglutide 3.0 mg daily. Food intake was evaluated by dietary recall. At baseline, OB group had increased cerebral bloo...
#2Mark TripputiH-Index: 1
Last. Sharon L. EdelsteinH-Index: 39
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#1Kieren J. MatherH-Index: 39
#2Ashley H. TjadenH-Index: 1
Last. Steven E. KahnH-Index: 101
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#1Brittany GaluppoH-Index: 1
Last. Nicola SantoroH-Index: 32
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#1Domenico Tricò (UniPi: University of Pisa)H-Index: 9
#2Alfonso Galderisi (UNIPD: University of Padua)H-Index: 10
Last. Sonia Caprio (Yale University)H-Index: 65
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AIMS: Non-Alcoholic Fatty Liver Disease (NAFLD) has been associated with reduced endogenous insulin clearance (EIC) and hepatic insulin resistance (HIRI). These relationships, however, might be differentially affected by the ethnic background, as populations of African ancestry are typically featured with reduced intrahepatic fat content (HFF%) but impaired EIC. Therefore, we evaluated the influence of the ethnicity on the relationships between HFF%, EIC and HIRI. METHODS: The HFF% was quantifie...
1 CitationsSource
#1Michelle Bloyd (NIH: National Institutes of Health)
#2Steven L. Coon (NIH: National Institutes of Health)H-Index: 33
Last. Edra London (NIH: National Institutes of Health)H-Index: 9
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