Sonia Caprio
Yale University
EndocrinologyInsulin resistanceInsulinDiabetes mellitusMedicine
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Publications 247
#1Sonia Caprio (Yale University)H-Index: 65
#2Nicola Santoro (Yale University)H-Index: 31
Last. Ram Weiss (Boston Children's Hospital)H-Index: 34
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Childhood obesity is one of the most serious global public-health challenges of the twenty-first century. Over the past four decades, the number of children and adolescents with obesity has risen more than tenfold. Worldwide, an increasing number of youth are facing greater exposure to obesity throughout their lives, and this increase will contribute to the early development of type 2 diabetes, fatty liver and cardiovascular complications. Herein, we provide a brief overview of trends in the glo...
#2Jessica NouwsH-Index: 4
Last. Sonia CaprioH-Index: 65
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Severe obesity (SO) affects about 6% of youth in US, augmenting the risks for cardiovascular disease and Type 2 diabetes.Herein, we obtained paired omental (omVAT) and abdominal subcutaneous (SAT) adipose tissue biopsies from obese girls with SO, undergoing sleeve gastrectomy (SG), to test whether differences in cellular and transcriptomic profiles between omVAT and SAT depots affect insulin sensitivity differentially. Following weight loss, these analyses were repeated in a subgroup of subjects...
#1Sofiya Gancheva (HHU: University of Düsseldorf)H-Index: 3
#2Daria Caspari (HHU: University of Düsseldorf)
Last. Jong-Hee Hwang (HHU: University of Düsseldorf)H-Index: 8
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BACKGROUND: Classical organic acidemias (OAs) result from defective mitochondrial catabolism of branched-chain amino acids (BCAAs). Abnormal mitochondrial function relates to oxidative stress, ectopic lipids and insulin resistance (IR). We investigated whether genetically impaired function of mitochondrial BCAA catabolism associates with cardiometabolic risk factors, altered liver and muscle energy metabolism, and IR. PATIENTS AND METHODS: In this case-control study, 31 children and young adults...
#1Alfonso Galderisi (Yale University)H-Index: 10
#2Domenico Tricò (Sant'Anna School of Advanced Studies)
Last. Sonia Caprio (Yale University)H-Index: 65
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CONTEXT: The time-to-glucose-peak following the oral glucose tolerance test (OGTT) is a highly reproducible marker for diabetes risk. In obese youths, we lack evidence for the mechanisms underlying the effects of the TCF7L2 rs7903146 variant on glucose peak. METHODS: We analyzed the metabolic phenotype and the genotype for the TCF7L2 rs7903146 in 630 obese youths with normal (NGT) and impaired (IGT) glucose tolerance. Participants underwent a 3-hour, 9-point OGTT to estimate, using the oral mini...
#1Giuseppina Rosaria Umano (Yale University)H-Index: 5
#1Giuseppina Rosaria Umano (Yale University)H-Index: 4
Last. Sonia Caprio (Yale University)H-Index: 65
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Insulin resistance exerts a key role in the pathogenesis of obesity-related comorbidities. A growing body of evidence has pointed out that ectopic fat distribution, instead of total adiposity, is the main predictor of metabolic derangement in adults and children. Indeed, lipid accumulation in insulin-sensitive organs, such as liver and skeletal muscle, might impair insulin action leading to insulin resistance. In this chapter, we review the scientific evidence of association between ectopic fat ...
#1Kevin Teo (University of Cambridge)
#2Kushala W M Abeysekera (UoB: University of Bristol)H-Index: 1
Last. Jake P. Mann (University of Cambridge)H-Index: 7
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A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in non-alcoholic fatty liver disease (NAFLD), however these findings have not been consistently replicated in the literature. Therefore, we aimed to establish whether rs641738 is a risk factor for NAFLD through meta-analysis. Data from 131,096 participants (7,692 with liver biopsies and 45,419 with imaging) was included in the meta-analysis. The minor T-allele of rs641738C>T ...
#1Alfonso Galderisi (Yale University)H-Index: 10
#2David Polidori (Janssen Pharmaceutica)H-Index: 26
Last. Sonia Caprio (Yale University)H-Index: 65
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We examined the relationship between insulin clearance, insulin sensitivity, and β-cell function and the longitudinal effect of insulin clearance on β-cell function in lean and obese insulin-sensitive and insulin-resistant adolescents. A hyperinsulinemic-euglycemic and a hyperglycemic clamp were performed in 110 youths to quantify hepatic and peripheral clearance, insulin sensitivity, and β-cell function (disposition index, DIh-clamp). Participants underwent an oral glucose tolerance test at bas...
#1Richard D. Khusial (Mercer University)H-Index: 1
#2Catherine E. Cioffi (Emory University)H-Index: 1
Last. Miriam B. Vos (Emory University)H-Index: 27
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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children, but diagnosis is challenging due to limited availability of noninvasive biomarkers. Machine learning applied to high‐resolution metabolomics and clinical phenotype data offers a novel framework for developing a NAFLD screening panel in youth. Here, untargeted metabolomics by liquid chromatography–mass spectrometry was performed on plasma samples from a combined cross‐sectional sample of children and ad...
2 CitationsSource
#1Alfonso GalderisiH-Index: 10
#2Domenico TricòH-Index: 9
Last. Sonia CaprioH-Index: 65
view all 8 authors...
Background: Beta-cell function can be dissected into a dynamic component, estimating the immediate secretion after glucose change, and a static component representing the insulin secreted at any given glucose level. We evaluated their clinical and genetic determinants as well as their effect on glucose time to peak in obese youths. Methods: A 3hOGTT was performed in 630 obese youths (374F, 13.6±3.1y, 33.3±7.5kg/m 2 ); dynamic (DI d ) and static (DI s ) components of beta-cell function were estim...