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Sonia Caprio
Yale University
245Publications
65H-index
18.4kCitations
Publications 245
Newest
Published on 2019in Pediatric Diabetes3.35
Fida Bacha31
Estimated H-index: 31
(BCM: Baylor College of Medicine),
Laure El ghormli13
Estimated H-index: 13
(GW: George Washington University)
+ 7 AuthorsSarah MacLeish2
Estimated H-index: 2
(Case Western Reserve University)
Richard D. Khusial (Mercer University), Catherine E. Cioffi1
Estimated H-index: 1
(Emory University)
+ 7 AuthorsBridget Pierpont20
Estimated H-index: 20
(Yale University)
Published on Jun 1, 2019in Diabetes7.20
Kristen J. Nadeau28
Estimated H-index: 28
,
Sharon L. Edelstein49
Estimated H-index: 49
+ 9 AuthorsMark Tripputi
Identifying features of obese dysglycemic youth that predict deterioration of glucose homeostasis is key to planning interventions and future management. In RISE, we evaluated β-cell responses by hyperglycemic clamp and 3-h oral glucose tolerance testing (OGTT), and glycemic progression in 91 obese 10-19 year old youth with impaired glucose tolerance (IGT, 60%) or recent-onset type 2 diabetes (T2D, 40%). Outcomes were measured at baseline (BAS) and following 12 months (M12) of treatment with met...
Published on Jun 1, 2019in Diabetes7.20
Alfonso Galderisi8
Estimated H-index: 8
,
Domenico Tricò7
Estimated H-index: 7
+ 5 AuthorsSonia Caprio65
Estimated H-index: 65
Background: Beta-cell function can be dissected into a dynamic component, estimating the immediate secretion after glucose change, and a static component representing the insulin secreted at any given glucose level. We evaluated their clinical and genetic determinants as well as their effect on glucose time to peak in obese youths. Methods: A 3hOGTT was performed in 630 obese youths (374F, 13.6±3.1y, 33.3±7.5kg/m 2 ); dynamic (DI d ) and static (DI s ) components of beta-cell function were estim...
Published on Jun 1, 2019in Diabetes7.20
Alfonso Galderisi8
Estimated H-index: 8
,
Domenico Tricò7
Estimated H-index: 7
+ 3 AuthorsRam Weiss33
Estimated H-index: 33
Background: Hyperinsulinemia results from β-cell ompensatory adaptation to insulin resistance and reduced insulin clearance. We examined the relationship between hepatic/peripheral insulin clearance and β-cell function in lean and obese insulin sensitive (IS) and insulin resistant (IR) adolescents. Methods: A 2-step euglycemic hyperinsulinemic clamp and an hyperglycemic clamp were performed in 153 youths (73F, 14.4±3.3y) to evaluate hepatic (MCR1) and peripheral (MCR2) insulin clearance, β-cell ...
Published on Jun 1, 2019in Diabetes7.20
Jessica Nouws4
Estimated H-index: 4
(Yale University),
Mark Fitch17
Estimated H-index: 17
(University of California, Berkeley)
+ 9 AuthorsGerald I. Shulman142
Estimated H-index: 142
(Yale University)
Patterns of abdominal fat distribution (for example, a high vs. low visceral adipose tissue [VAT]/[VAT + subcutaneous adipose tissue (SAT)] ratio), independent of obesity, during adolescence carry a high risk for insulin resistance and type 2 diabetes. Longitudinal follow-up of a cohort of obese adolescents has recently revealed that a high ratio (high VAT/[VAT + SAT]) is a major determinant of fatty liver and metabolic impairment over time, with these effects being more pronounced in girls than...
Published on Jun 1, 2019in Diabetes7.20
Catherine E. Cioffi1
Estimated H-index: 1
,
K.M. Venkat Narayan54
Estimated H-index: 54
+ 4 AuthorsMiriam B. Vos27
Estimated H-index: 27
Hepatic fat accumulation is often associated with cardiometabolic disease (CMD) risk factors in children, but the mechanism is unclear. We measured untargeted metabolomics in plasma from 219 obese children/adolescents with (37%) and without (63%) fatty liver assessed by magnetic resonance imaging. An integrative network analysis, which involved several steps including pairwise association analyses and a multilevel community detection algorithm, was performed using xMWAS to explore clustering pat...
Published on Jun 1, 2019in Diabetes7.20
Alfonso Galderisi8
Estimated H-index: 8
,
Michelle Van Name6
Estimated H-index: 6
+ 2 AuthorsSonia Caprio65
Estimated H-index: 65
Published on Jun 1, 2019in Diabetes7.20
Kristina M. Utzschneider33
Estimated H-index: 33
,
Andrea Mari55
Estimated H-index: 55
+ 9 AuthorsThomas A. Buchanan70
Estimated H-index: 70
Results from hyperglycemic clamps in the Restoring Insulin Secretion (RISE) Study found that youth (10-19 y) with impaired glucose tolerance (IGT) or early type 2 diabetes (T2D) are more insulin resistant and secrete more insulin than adults (20-65 y), despite similar BMI. Here we use Mari modeling of RISE 3-h OGTT data to explore differences in β-cell function between youth and adults. The Mari model describes the relationship between insulin secretion rate (ISR) and glucose concentration. The ...
Published on Jun 1, 2019in Diabetes7.20
Ashley H. Tjaden , Sharon L. Edelstein49
Estimated H-index: 49
+ 8 AuthorsAnny H. Xiang42
Estimated H-index: 42
Fasting and 2-h OGTT glucose along with HbA1c are used in clinical practice for diagnosing IGT and T2D, and in clinical trials for assessing eligibility. While previous studies found poor reproducibility of such measures in adults and youth at risk for dysglycemia, no studies have assessed group differences in reproducibility. We assessed reproducibility of glycemic measures in treatment-naive youth and adults screened for RISE. Central laboratory measurements of plasma glucose and HbA1c from tw...
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