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Monique E. Arlot
French Institute of Health and Medical Research
EndocrinologyBone remodelingOsteoporosisMedicineOsteoid
80Publications
37H-index
6,825Citations
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Publications 79
Newest
#1Deborah GensburgerH-Index: 6
#2Rita DeroisyH-Index: 24
Last. Jean-Yves Reginster (University of Liège)H-Index: 95
view all 6 authors...
The purpose of this study was to adapt various staining methods for the detection of microdamage in human bone, while preserving tetracycline labels. We describe two staining methods using calcein green and xylenol orange, first developed in ewe bone samples and validated in human trabecular bone samples. In ewe bones, we found that calcein green at 0.5 mM concentration diluted in 100% ethanol as well as xylenol orange at 5 mM were the most adequate fluorochromes both to detect microdamage and p...
3 CitationsSource
#1D. BrianconH-Index: 5
#2P. D'ArandaH-Index: 1
Last. P. J. Meunie (French Institute of Health and Medical Research)H-Index: 90
view all 7 authors...
To assess whether an interval of a few hours would be advisable between an intake of sodium fluoride (NaF) and that of calcium salts when treating osteoporotic patients with vertebral collapse, we carried out three pharmacokinetic studies in 12 healthy fasting volunteer subjects to compare the fluoride bioavailability provided by NaF alone and NaF combined with two calcium salts. The results were as follows: (1) When NaF is accompanied by calcium, the fluoride peak level is lower and delayed. (2...
4 CitationsSource
#1Pascale M. Chavassieux (French Institute of Health and Medical Research)H-Index: 2
#2Monique E. Arlot (French Institute of Health and Medical Research)H-Index: 37
Last. P. J. Meunie (French Institute of Health and Medical Research)H-Index: 90
view all 10 authors...
Effects of alendronate (ALN) on bone quality and turnover were assessed in 88 patients (52 women and 36 men aged 22‐75 years) who received long-term oral glucocorticoid exposure. Patients were randomized to receive oral placebo or alendronate 2.5, 5, or 10 mg/day for 1 year and stratified according to the duration of their prior glucocorticoid treatment. Transiliac bone biopsies were obtained for qualitative and quantitative analysis after tetracycline double-labeling at the end of 1 year of tre...
99 CitationsSource
#1Pawel Szulc (French Institute of Health and Medical Research)H-Index: 28
#2Monique E. Arlot (French Institute of Health and Medical Research)H-Index: 37
Last. Pierre D. Delmas (French Institute of Health and Medical Research)H-Index: 137
view all 6 authors...
We previously showed that circulating undercarboxylated osteocalcin (ucOC) is elevated in elderly women and is a powerful marker of the subsequent risk of hip fracture in elderly institutionalized women (J Clin Invest 1993; 91:1769). To investigate the relationship between bone mass and ucOC, we measured bone mineral density (BMD) of the hip with dual-energy x-ray absorptiometry in 98 elderly institutionalized women, 81.4 + 6.0 years old. ucOC was negatively correlated with BMD at all sites (r =...
238 CitationsSource
#1Jonathan Reeve (Medical Research Council)H-Index: 7
#2Monique E. Arlot (French Institute of Health and Medical Research)H-Index: 37
Last. P. J. Meunie (French Institute of Health and Medical Research)H-Index: 90
view all 8 authors...
Bone formation and resorption have been measured in patients with idiopathic osteoporosis by histomorphometry of 7.5-mm trephine biopsies and in the whole body by 85Sr radiotracer methodology and calcium balances. The studies were synchronized and most were preceded by double in vivo tetracycline labeling. Correlations between histological and kinetic bone formation indices were better when better when based on the extent of double tetracycline labels than on measurements of osteoid by visible l...
38 CitationsSource
#1R. HespH-Index: 8
#2Monique E. Arlot (French Institute of Health and Medical Research)H-Index: 37
Last. Jonathan ReeveH-Index: 43
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In 28 patients with idiopathic or postmenopausal type 1 (spinal crush fracture) osteoporosis, resorption indices and dynamic measurements of trabecular bone formation based on in vivo tretracycline labeling in 7.5 mm transiliac biopsies have been compared with trends in radial cortical and trabecular bone density measured with computed tomography. Positive correlations were observed between trabecular bone density trends in the radius and indices of bone formation in the ilium. These were improv...
8 CitationsSource
#1May Parisien (Columbia University)H-Index: 21
#2S. Charhon (French Institute of Health and Medical Research)H-Index: 18
Last. P. J. Meunie (French Institute of Health and Medical Research)H-Index: 90
view all 7 authors...
To evaluate the potential role of aluminum (Al) in a subset of dialysis patients with aplastic bone disease, we have studied tetracycline-labeled bone biopsies of 32 patients (22 males and 10 females, 45–73 years) on maintenance hemodialysis. Selection criteria included normal resorption surfaces (RS) and osteoid thickness. Eleven patients (Group I) had no stainable bone Al (Al -; 61.7 ± 7.2 years) and 21 (Group II) had stainable bone Al (Al +; 57.7 ± 6.8 years). Serum Al was normal to slightly ...
46 CitationsSource
#1Patrick Garnero (French Institute of Health and Medical Research)H-Index: 90
#2Olivier Borel (French Institute of Health and Medical Research)H-Index: 12
Last. Pierre D. Delmas (French Institute of Health and Medical Research)H-Index: 137
view all 5 authors...
Vitamin D receptor (VDR) gene polymorphisms have been reported to account for most of the well established genetic influence on bone mineral density (BMD). However, discordant studies have been published and it is still not clear whether VDR genotypes influence bone mass accretion and/or postmenopausal bone loss. In this study, we analyzed VDR gene polymorphisms, i.e., that of BsmI, ApaI, and TaqI restriction enzymes in 268 untreated postmenopausal women 1-26 years postmenopausal. There were 37 ...
156 CitationsSource
#1Roland Chapurlat (French Institute of Health and Medical Research)H-Index: 53
#2Monique E. Arlot (French Institute of Health and Medical Research)H-Index: 37
Last. Pierre D. Delmas (French Institute of Health and Medical Research)H-Index: 137
view all 6 authors...
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