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Vasileia Balabanidou
University of Crete
13Publications
4H-index
94Citations
Publications 13
Newest
#1Amy Lynd (LSTM: Liverpool School of Tropical Medicine)H-Index: 11
#2Vasileia Balabanidou (FORTH: Foundation for Research & Technology – Hellas)H-Index: 4
Last.Gareth Lycett (LSTM: Liverpool School of Tropical Medicine)H-Index: 14
view all 7 authors...
Oenocytes are an insect cell type having diverse physiological functions ranging from cuticular hydrocarbon (CHC) production to insecticide detoxification that may impact their capacity to transmit pathogens. To develop functional genetic tools to study Anopheles gambiae oenocytes, we have trapped an oenocyte enhancer to create a transgenic mosquito Gal4 driver line that mediates tissue-specific expression. After crossing with UAS-reporter lines, An. gambiae oenocytes are fluorescently tagged th...
#2Mary KefiH-Index: 1
Last.Anastasia KampourakiH-Index: 4
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Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread, is rapidly increasing in spec...
Abstract Cuticular hydrocarbon (CHC) biosynthesis is a major pathway of insect physiology. In Drosophila melanogaster the cytochrome P450 CYP4G1 catalyses the insect-specific oxidative decarbonylation step, while in the malaria vector Anopheles gambiae , two CYP4G paralogues, CYP4G16 and CYP4G17 are present. Analysis of the subcellular localization of CYP4G17 and CYP4G16 in larval and pupal stages revealed that CYP4G16 preserves its PM localization across developmental stages analyzed; however C...
#1Gildas A. Yahouédo (IRD: Institut de recherche pour le développement)H-Index: 3
#2Fabrice Chandre (IRD: Institut de recherche pour le développement)H-Index: 44
Last.Sylvie Cornelie (IRD: Institut de recherche pour le développement)H-Index: 16
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BACKGROUND: Vector control is the main intervention in malaria control and elimination strategies. However, the development of insecticide resistance is one of the major challenges for controlling malaria vectors. Anopheles arabiensis populations in Ethiopia showed resistance against both DDT and the pyrethroid deltamethrin. Although a L1014F target-site resistance mutation was present in the voltage gated sodium channel of investigated populations, the levels of resistance and biochemical studi...
#1Vasileia Balabanidou (FORTH: Foundation for Research & Technology – Hellas)H-Index: 4
#2Linda Grigoraki (UoC: University of Crete)H-Index: 6
Last.John Vontas (FORTH: Foundation for Research & Technology – Hellas)H-Index: 39
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Intense use of insecticides has resulted in the selection of extreme levels of resistance in insect populations. Therefore understanding the molecular basis of insecticide resistance mechanisms becomes critical. Penetration resistance refers to modifications in the cuticle that will eventually slow down the penetration of insecticide molecules within insects' body. So far, two mechanisms of penetration resistance have been described, the cuticle thickening and the altering of cuticle composition...
#1Patricia PignatelliH-Index: 11
#2Victoria InghamH-Index: 4
Last.Hilary RansonH-Index: 1
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The role of ABC transporters in conferring insecticide resistance has received much attention recently. Here we identify ABC transporters differentially expressed in insecticide resistant populations of the malaria vector, Anopheles gambiae. Although we found little evidence that the orthologs of the multidrug resistance proteins described in other species are associated with resistance in An. gambiae we did identify a subset of ABC proteins consistently differentially expressed in pyrethroid re...
#1Gildas A. Yahouédo (IRD: Institut de recherche pour le développement)H-Index: 3
#2Fabrice Chandre (IRD: Institut de recherche pour le développement)H-Index: 44
Last.Sylvie Cornelie (IRD: Institut de recherche pour le développement)H-Index: 16
view all 9 authors...
To tackle the problem of insecticide resistance, all resistance mechanisms need to be studied. This study investigated the involvement of the cuticle in pyrethroid resistance in a strain of Anopheles gambiae, MRS, free of kdr mutations. Bioassays revealed MRS to be resistant to pyrethroids and DDT, indicated by increasing knockdown times and resistance ratios. Moreover, biochemical analysis indicated that metabolic resistance based on enhanced CYP450 activity may also play a role. Insecticide pe...
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