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Koichi Kato
Nagoya City University
448Publications
50H-index
8,673Citations
Publications 448
Newest
Published on Dec 1, 2019in Scientific Reports 4.01
Yukihiro Yoshida (RMIT: RMIT University), Hidetsugu Fujigaki11
Estimated H-index: 11
(RMIT: RMIT University)
+ 8 AuthorsToshitaka Nabeshima11
Estimated H-index: 11
(RMIT: RMIT University)
The enzyme kynurenine aminotransferase (KAT) catalyses the conversion of kynurenine (KYN) to kynurenic acid (KYNA). Although the isozymes KAT1–4 have been identified, KYNA is mainly produced by KAT2 in brain tissues. KNYA is an antagonist of N-methyl-D-aspartate and α-7-nicotinic acetylcholine receptors, and accumulation of KYNA in the brain has been associated with the pathology of schizophrenia. Therefore, KAT2 could be exploited as a therapeutic target for the management of schizophrenia. Alt...
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Published on Mar 13, 2019in Scientific Reports 4.01
Narentuya2
Estimated H-index: 2
(Nagoya University),
Yoshiko Takeda-Uchimura7
Estimated H-index: 7
(Nagoya University)
+ 7 AuthorsKenji Uchimura17
Estimated H-index: 17
(Lille University of Science and Technology)
Keratan sulfate (KS) is a carbohydrate side chain covalently attached to extracellular proteoglycans. KS is composed of disaccharide units of 6-sulfated N-acetylglucosamine (GlcNAc) and galactose. We have previously shown that GlcNAc-6-O-sulfotransferase (GlcNAc6ST) 1 encoded by Chst2 is an enzyme necessary for the synthesis of GlcNAc-6-sulfated KS chains that are required for neuronal plasticity in the visual cortex of the mouse brain during the critical period, but not in adulthood. Here, we s...
1 Citations Source Cite
Published on Jul 1, 2019in Antibodies
Saeko Yanaka4
Estimated H-index: 4
,
Rina Yogo3
Estimated H-index: 3
+ 8 AuthorsTakumi Yamaguchi15
Estimated H-index: 15
The Fc portion of immunoglobulin G (IgG) is a horseshoe-shaped homodimer, which interacts with various effector proteins, including Fcγ receptors (FcγRs). These interactions are critically dependent on the pair of N-glycans packed between the two CH2 domains. Fucosylation of these N-glycans negatively affects human IgG1-FcγRIIIa interaction. The IgG1-Fc crystal structures mostly exhibit asymmetric quaternary conformations with divergent orientations of CH2 with respect to CH3. We aimed to provid...
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Published on Jun 1, 2019in Diabetes 7.20
Hiromi Shimoda , Yusuke Seino16
Estimated H-index: 16
+ 15 AuthorsYuichiro Yamada38
Estimated H-index: 38
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Published on Jun 1, 2019
Yasuhiro Yunoki1
Estimated H-index: 1
(Nagoya City University),
Kentaro Ishii (Nagoya City University)+ 4 AuthorsKoichi Kato50
Estimated H-index: 50
(Nagoya City University)
The cyanobacterial clock is controlled via the interplay among KaiA, KaiB, and KaiC, which generate a periodic oscillation of KaiC phosphorylation in the presence of ATP. KaiC forms a homohexamer harboring 12 ATP-binding sites and exerts ATPase activities associated with its autophosphorylation and dephosphorylation. The KaiC nucleotide state is a determining factor of the KaiB–KaiC interaction; however, its relationship with the KaiA–KaiC interaction has not yet been elucidated. With the attemp...
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Published on Jun 1, 2019in Bioorganic & Medicinal Chemistry Letters 2.45
Kiminori Ohta1
Estimated H-index: 1
(Showa University),
Takumi Ogawa10
Estimated H-index: 10
+ 2 AuthorsYasuyuki Endo34
Estimated H-index: 34
Abstract Estrogen receptor (ER) exhibits two subtypes, ERα and ERβ, whose biological functions are quite different despite expression in the same tissues. We developed diiodo-m-carborane derivative 3a , which showed 14-fold selectivity for ERβ with high binding affinity toward ERβ. Interestingly, introduction of an alkyl group into the carbon atom of the m-carborane cage of 3a markedly enhanced the binding affinity toward ERα and decreased affinity toward ERβ. C- n -propyl derivative 3d showed 2...
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Published on May 15, 2019in International Journal of Molecular Sciences 4.18
Tomoki Nakayoshi2
Estimated H-index: 2
,
Shuichi Fukuyoshi5
Estimated H-index: 5
+ 2 AuthorsAkifumi Oda12
Estimated H-index: 12
Aspartic acid (Asp) residues are prone to non-enzymatic stereoinversion, and Asp-residue stereoinversion is believed to be mediated via a succinimide (SI) intermediate. The stereoinverted Asp residues are believed to cause several age-related diseases. However, in peptides and proteins, few studies have reported the stereoinversion of glutamic acid (Glu) residues whose structures are similar to that of Asp. We previously presumed that Glu-residue stereoinversion proceeds via a glutarimide (GI) i...
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Published on May 9, 2019in International Journal of Molecular Sciences 4.18
Taichiro Sekiguchi1
Estimated H-index: 1
,
Tadashi Satoh15
Estimated H-index: 15
+ 10 AuthorsSusumu Uchiyama33
Estimated H-index: 33
Eukaryotic proteasomes harbor heteroheptameric α-rings, each composed of seven different but homologous subunits α1–α7, which are correctly assembled via interactions with assembly chaperones. The human proteasome α7 subunit is reportedly spontaneously assembled into a homotetradecameric double ring, which can be disassembled into single rings via interaction with monomeric α6. We comprehensively characterized the oligomeric state of human proteasome α subunits and demonstrated that only the α7 ...
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Published on May 7, 2019in International Journal of Molecular Sciences 4.18
Tadashi Satoh15
Estimated H-index: 15
,
Maho Yagi-Utsumi13
Estimated H-index: 13
+ 3 AuthorsKoichi Kato50
Estimated H-index: 50
The 26S proteasome is critical for the selective degradation of proteins in eukaryotic cells. This enzyme complex is composed of approximately 70 subunits, including the structurally homologous proteins α1–α7, which combine to form heptameric rings. The correct arrangement of these α subunits is essential for the function of the proteasome, but their assembly does not occur autonomously. Assembly of the α subunit is assisted by several chaperones, including the PAC3-PAC4 heterodimer. In this stu...
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Published on May 1, 2019in FEBS Letters 2.67
Yoichiro Harada2
Estimated H-index: 2
(Kadai: Kagoshima University),
Yasuhiko Kizuka17
Estimated H-index: 17
(Gidai: Gifu University)
+ 6 AuthorsIkuro Maruyama47
Estimated H-index: 47
(Kadai: Kagoshima University)
1 Citations Source Cite
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