Kishan Veerabrahma
Kakatiya University
PharmacokineticsBioavailabilityChemistryIn vivoChromatography
What is this?
Publications 23
#1Dinesh Suram (Kakatiya University)H-Index: 1
#2Arjun Narala (Kakatiya University)H-Index: 2
Last. Kishan Veerabrahma (Kakatiya University)H-Index: 9
view all 3 authors...
Abstract:Iloperidone (ILO) is an anti-psychotic, used in schizophrenia. It has low bioavailability (36%) due to low solubility and first pass effect. Oral solid self microemulsifying drug delivery ...
#1Arjun Narala (Kakatiya University)H-Index: 2
#2Swathi Guda (Kakatiya University)H-Index: 1
Last. Kishan Veerabrahma (Kakatiya University)H-Index: 9
view all 3 authors...
Rebamipide has low oral bioavailability (10%) due to its low solubility and permeability. Lipid nanoemulsions (LNEs) were prepared in order to improve its oral bioavailability. Rebamipide-loaded lipid nanoemulsions were formulated by hot homogenization and ultrasonication method. Olive oil and egg lecithin in various concentrations as emulsifier were used in the preparation of LNEs. The lipid nanoemulsions were evaluated for various parameters. The globule size, polydispersity index (PDI), and z...
1 CitationsSource
#1Shravan Kumar Pitta (Kakatiya University)H-Index: 1
#2Narendar Dudhipala (Kakatiya University)H-Index: 5
Last. Kishan Veerabrahma (Kakatiya University)H-Index: 9
view all 4 authors...
AbstractThe aim was to prepare an optimized zolmitriptan (ZT)-loaded transfersome formulation using Box–Behnken design for improving the bioavailability by nasal route for quick relief of migraine and further to compare with a marketed nasal spray. Here, three factors were evaluated at three levels. Independent variables include: amount of soya lecithin (X1), amount of drug (X2) and amount of tween 80 (X3). The dependent responses were vesicle size (Y1), flexibility index (Y2) and regression coe...
2 CitationsSource
#1B Arun (Kakatiya University)H-Index: 1
#2D Narendar (Kakatiya University)H-Index: 1
Last. Kishan Veerabrahma (Kakatiya University)H-Index: 9
view all 3 authors...
AbstractThe aim was to enhance the oral bioavailability of olmesartan medoxomil (OM) by preparing solid lipid nanoparticles (SLNs) and comparing with nanosuspension (OM-NS). OM-SLNs and OM-NS were prepared by known methods. Prepared SLNs were evaluated for physical characters and in vivo pharmacokinetic (PK) performance in rats. OM-NS showed more than four-fold increase in the solubility. During DSC and XRD studies, drug incorporated in SLNs was found to be in amorphous form. The relative bioava...
3 CitationsSource
Candesartan cilexetil (CC), an antihypertensive drug, has low oral bioavailability due to poor solubility and hepatic first-pass metabolism. These are major limitations in oral delivery of CC. Several approaches are known to reduce the problems of solubility and improve the bioavailability of CC. Among various approaches, nanotechnology-based delivery of CC has potential to overcome the challenges associated with the oral administration. This review focuses on various nano-based delivery systems...
1 CitationsSource
Abstract The intent of this investigation was to improve pharmacokinetic (PK) and pharmacodynamic (PD) effects of Rosuvastatin calcium (RC) by solid lipid nanoparticles (SLNs). RC is anti-hyperlipidemic drug with low oral bioavailability (20%) due to first-pass metabolism. Hot homogenization followed by ultrasonication method was used to prepare RC-SLNs with stearic acid, glyceryl behenate and glyceryl trilaurate as lipid matrices, egg lecithin and poloxamer 188 as surfactants. The prepared SLNs...
9 CitationsSource
#1Venu Madhav Katla (Kakatiya University)H-Index: 1
#2Kishan Veerabrahma (Kakatiya University)H-Index: 9
Abstract The objective of the study was to develop solid self micro emulsifying drug delivery system (SSMED) for enhancement of oral bioavailability of losartan (LOS). Solubility of LOS in various vehicles was determined. Micro emulsion region was identified by constructing phase diagram containing surfactant: co-surfactant mixture (1:1 and 2:1), oil and water. Formulations were initially checked for droplet size upon addition to water. The formulations, which resulted in in vitro dissolution. T...
1 CitationsSource
#1Narendar Dudhipala (Kakatiya University)H-Index: 5
#2Kishan Veerabrahma (Kakatiya University)H-Index: 9
AbstractCandesartan cilexetil (CC) is used in the treatment of hypertension and heart failure. It has poor aqueous solubility and low oral bioavailability. In this work, CC loaded solid lipid nanoparticles (CC-SLNs) were developed to improve the oral bioavailability. Components of the SLNs include either of trimyristin/tripalmitin/tristearin, and surfactants (Poloxamer 188 and egg lecithin E80). The CC loaded nanoparticles were prepared by hot homogenization followed by ultrasonication method. T...
26 CitationsSource
#1Narendar Dudhipala (Kakatiya University)H-Index: 5
#2Kishan Veerabrahma (Kakatiya University)H-Index: 9
AbstractObjective: Nisoldipine (ND) is a potential antihypertensive drug with low oral bioavailability. The aim was to develop an optimal formulation of ND-loaded solid lipid nanoparticles (ND-SLNs) for improved oral bioavailability and pharmacodynamic effect by using a two-factor, three-level central composite design. Glyceryl trimyristate (Dynasan 114) and egg lecithin were selected as independent variables. Particle size (Y1), PDI (Y2) and entrapment efficiency (EE) (Y3) of SLNs were selected...
21 CitationsSource
#1Ramesh Bomma (Kakatiya University)H-Index: 3
#2Kishan Veerabrahma (Kakatiya University)H-Index: 9
Abstract The objective of the present investigation was to apply statistical design for the development of risedronate sodium floating-bioadhesive tablets (RSFBT) employing response surface methodology (RSM). A central composite design (CCD) was developed using Design of Expert (DOE) software to study the effect of formulation variables on the drug delivery system. The RSFBT were prepared by direct compression using hydroxy propyl methyl cellulose (HPMC K100M) as release retardant; carbopol (CP ...
1 Citations