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Murray J. Adams
Murdoch University
HematologyImmunologyTissue factor pathway inhibitorMedicinePlatelet
130Publications
15H-index
812Citations
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Publications 130
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#1Yik C. Ho (RMIT: RMIT University)H-Index: 1
#2Kdk Ahuja (RMIT: RMIT University)H-Index: 21
Last. Murray J. Adams (Murdoch University)H-Index: 15
view all 4 authors...
: Antibeta-2-glycoprotein 1 (antibeta2GP1) antibodies are associated with increased risk of thrombosis in patients with systemic lupus erythematosus (SLE). The specific effect(s) of antibeta2GP1 antibodies on platelets are unclear. Platelet activation in response to antiplatelet antibodies has been shown to induce shedding of the ectodomain of the platelet collagen receptor, glycoprotein VI (GPVI), releasing soluble GPVI (sGPVI). The aim of this study was to therefore determine whether antibeta2...
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#1Jack Kean (UTAS: University of Tasmania)H-Index: 1
#2Ashleigh Pearton (UTAS: University of Tasmania)H-Index: 1
Last. Emma K. Zadow (UTAS: University of Tasmania)H-Index: 4
view all 8 authors...
Whilst athletes are the epitome of health, venous thromboembolisms (VTE) including deep vein thrombosis and pulmonary embolism have been demonstrated to occur in well-trained athletes. VTE is frequently misdiagnosed and poorly treated within this population, often resulting in career or life-threatening ramifications. Furthermore, VTE risk rises with increasing age (> 40 years), potentially affecting masters athletes. A 44-year-old well-trained male cyclist volunteered to participate in a resear...
1 CitationsSource
#1Murray J. Adams (Murdoch University)H-Index: 15
#2James W. Fell (RMIT: RMIT University)H-Index: 22
We are thrilled to bring you this cross-disciplinary special issue of Seminars in Thrombosis and Hemostasis. This issue focuses on two specific aspects of hemostasis and exercise: (1) how exercise affects the hemostatic system in healthy individuals, including professional and well-trained athletes, and (2) the effects of exercise on patient groups with hemostatic abnormalities, including thrombotic and bleeding disorders, in improving overall health and lifestyle. Paradoxically, the issue's foc...
1 CitationsSource
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#1Emma K. Zadow (RMIT: RMIT University)H-Index: 4
#2Murray J. Adams (RMIT: RMIT University)H-Index: 15
Last. James W. Fell (RMIT: RMIT University)H-Index: 22
view all 5 authors...
While athletes are often considered the epitome of health due to their physique and lowered potential for metabolic and cardiovascular diseases, they may also be at risk for the onset and development of venous thromboembolism (VTE). In an attempt to achieve and remain competitive, athletes are frequently exposed to numerous athlete-specific risk factors, which may predispose them to VTE through the disruption of factors associated with Virchow's triad (i.e., hypercoagulability, venous stasis, an...
5 CitationsSource
#1Yik C. Ho (RMIT: RMIT University)H-Index: 1
#2Kdk Ahuja (RMIT: RMIT University)H-Index: 21
Last. Murray J. Adams (RMIT: RMIT University)H-Index: 15
view all 3 authors...
Anti-beta-2-glycoprotein 1 (anti-β2GP1) antibodies are associated with increased thrombotic risk in patients with autoimmune disease. There is conflicting evidence on the effects of anti-β2GP1 antibodies on platelets, with both enhanced and inhibited aggregation previously reported. However, previous studies did not include isotype antibodies to ensure the observed effects were due to anti-β2GP1 antibodies. The aims of this study were to (1) investigate the effects of anti-β2GP1 antibodies on co...
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#1Gabrielle C. Musk (UWA: University of Western Australia)H-Index: 13
#2Murray J. Adams (Murdoch University)H-Index: 15
Last. Claire R. Sharp (Murdoch University)H-Index: 15
view all 5 authors...
We investigated the incidence of ex vivo incompatibility between ovine maternal RBC and fetal plasma. Time-mated singleton pregnant ewes (n = 8) underwent cesarean delivery of the fetus; at the time of delivery, paired maternal and fetal blood samples were collected and subsequently separated for storage as packed RBC and fresh frozen plasma. Gel column crossmatching was performed 3 to 4 wk later. All fetus–dam crossmatches were considered major crossmatches, combining fetal (recipient) plasma w...
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#1Emma K. Zadow (UTAS: University of Tasmania)H-Index: 4
#2Murray J. Adams (UTAS: University of Tasmania)H-Index: 15
Last. James W. Fell (UTAS: University of Tasmania)H-Index: 22
view all 12 authors...
Purpose: Compression socks are frequently used in the treatment and prevention of lower-limb pathologies; however, when combined with endurance-based exercise, the impact of compression socks on haemostatic activation remains unclear. Objectives: To investigate the effect of wearing compression socks on coagulation and fibrinolysis following a marathon. Methods: Sixty-seven participants [43 males (mean ± SD: age: 46.7 ± 10.3 year) and 24 females (age: 40.0 ± 11.0 year)] were allocated into a com...
2 CitationsSource
#1S AlmaghrabiH-Index: 2
#2Murray J. AdamsH-Index: 15
Last. Kdk AhujaH-Index: 21
view all 4 authors...
Capsaicinoids, including capsaicin (CAP) and dihydrocapsaicin (DHC), the pungent principles of pepper fruits, individually inhibit in-vitro platelet aggregation. However, their effects, when present together, are not known. The aims of this study were to compare the effects of CAP and DHC alone, and in combination in the ratio that they are found in chilies (∼60% CAP : 40% DHC), on in-vitro platelet aggregation, platelet count and thromboxane B2 (TXB2) formation. The effects of 12.5 and 6.25 μmo...
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#1Emma K. Zadow (RMIT: RMIT University)H-Index: 4
#2Cecilia M. Kitic (RMIT: RMIT University)H-Index: 10
Last. Murray J. Adams (RMIT: RMIT University)H-Index: 15
view all 5 authors...
AbstractExercise has been demonstrated to have considerable effects upon haemostasis, with activation dependent upon the duration and intensity of the exercise bout. In addition, markers of coagulation and fibrinolysis have been shown to possess circadian rhythms, peaking within the morning (0600–1200 h). Therefore, the time of day in which exercise is performed may influence the activation of the coagulation and fibrinolytic systems. This study aimed to examine coagulation and fibrinolytic resp...
6 CitationsSource
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