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Chung Yeng Looi
Taylors University
Molecular biologyChemistryApoptosisBiochemistryBiology
95Publications
23H-index
1,465Citations
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Publications 97
Newest
#1Yi Ying CheokH-Index: 2
#1Cheok Yy (UM: University of Malaya)
Last. Won Fen Wong (UM: University of Malaya)H-Index: 20
view all 5 authors...
Chlamydia trachomatis and C. pneumoniae are members of the Chlamydiaceae family of obligate intracellular bacteria. The former causes diseases predominantly at the mucosal epithelial layer of the urogenital or eye, leading to pelvic inflammatory diseases or blindness; while the latter is a major causative agent for pulmonary infection. On top of these well-described diseases at the respective primary infection sites, Chlamydia are notoriously known to migrate and cause pathologies at remote site...
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#1Mohamad Hamdi Zainal-Abidin (UM: University of Malaya)H-Index: 2
#2Maan Hayyan (UM: University of Malaya)H-Index: 29
Last. Chung Yeng Looi (Taylors University)H-Index: 23
view all 5 authors...
Deep eutectic solvents (DES) are an alternative to conventional functionalizing agents. These neoteric functionalizing agents have been reported to improve the dispersibility and biocompatibility of graphene in the cellular environment. DES-functionalized graphene also has significantly greater tamoxifen (TAM)-loading capacity than non-functionalized graphene. Therefore, this study investigated the anti-cancer properties of TAM-loaded graphene against cancerous cells. TAM-loaded, DES-functionali...
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#1Mohamad Hamdi Zainal-Abidin (UM: University of Malaya)H-Index: 2
#1Mohamad Hamdi Zainal Abidin (UM: University of Malaya)H-Index: 3
Last. Chung Yeng Looi (Taylors University)H-Index: 23
view all 5 authors...
Abstract The applications of eutectic systems, including deep eutectic solvents (DESs), in diverse sectors have drawn significant interest from researchers, academicians, engineers, medical scientists, and pharmacists. Eutecticity increases drug dissolution, improves drug penetration, and acts as a synthesis route for drug carriers. To date, DESs have been extensively explored as potential drug delivery systems on account of their unique properties such as tunability and chemical and thermal sta...
2 CitationsSource
#1Heng Choon Cheong (UM: University of Malaya)H-Index: 2
#2Polly Soo Xi Yap (UM: University of Malaya)H-Index: 2
Last. Won Fen Wong (UM: University of Malaya)H-Index: 20
view all 16 authors...
The cervical microbiota constitutes an important protective barrier against the invasion of pathogenic microorganisms. A disruption of microbiota within the cervical milieu has been suggested to be a driving factor of sexually transmitted infections. These include Chlamydia trachomatis which frequently causes serious reproductive sequelae such as infertility in women. In this study, we profiled the cervical microbial composition of a population of 70 reproductive-age Malaysian women; among which...
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#1Chin-Yap LohH-Index: 1
#2Jian Yi ChaiH-Index: 1
Last. Chung Yeng LooiH-Index: 23
view all 8 authors...
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due to its emerging role as a pivotal driver of tumorigenesis, targeting EMT is of great therapeutic interest in counteracting metastasis and chemoresistance in cancer patients. The hallmark of EMT is the upregulation of N-cadherin followed by the downregulation of E-cadherin, and this process is regulated by a complex network of ...
4 CitationsSource
#1Pei Pei Chong (Taylors University)H-Index: 16
#2Voon Kin Chin (Taylors University)H-Index: 3
Last. Voon Chen Yong (Taylors University)H-Index: 3
view all 6 authors...
Irritable bowel syndrome (IBS) is a functional disorder which affects a large proportion of the population globally. The precise etiology of IBS is still unknown, although consensus understanding proposes IBS to be of multifactorial origin with yet undefined subtypes. Genetic and epigenetic factors, stress-related nervous and endocrine systems, immune dysregulation and the brain-gut axis seem to be contributing factors that predispose individuals to IBS. In addition to food hypersensitivity, tox...
1 CitationsSource
#1Heng Choon CheongH-Index: 2
Last. Won Fen WongH-Index: 1
view all 6 authors...
Bacteria of the Chlamydiaceae family are a type of Gram-negative microorganism typified by their obligate intracellular lifestyle. The majority of the members in the Chlamydiaceae family are known pathogenic organisms that primarily infect the host mucosal surfaces in both humans and animals. For instance, Chlamydia trachomatis is a well-known etiological agent for ocular and genital sexually transmitted diseases, while C. pneumoniae has been implicated in community-acquired pneumonia in humans....
1 CitationsSource
#1Chin-Yap Loh (Taylors University)H-Index: 1
#2Aditya Arya (Taylors University)H-Index: 16
Last. Chung Yeng Looi (Taylors University)H-Index: 23
view all 6 authors...
Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs from different signaling pathways. Each family member plays unique functions in signal transduction and crucial in mediating cellular responses to different kind of cytokines. STAT family members notably STAT3 and STAT5 have been implicated in cancer progression whereas STAT1 plays opposite role by suppressing tumor growth. Persistent STA...
11 CitationsSource
#1Heng Choon Cheong (UM: University of Malaya)H-Index: 2
#2Chalystha Yie Qin Lee (UM: University of Malaya)H-Index: 2
Last. Sazaly AbuBakar (UM: University of Malaya)H-Index: 35
view all 15 authors...
Abstract Background Persistent inflammation caused by Chlamydia trachomatis in the female genital compartment represents one of the major causes of pelvic inflammatory disease (PID), ectopic pregnancy and infertility in females. Here, we examined the pro-inflammatory cytokine response following stimulation with three different types of C. trachomatis antigens, viz. chlamydial protease-like factor (CPAF), heat shock protein 60 (HSP60) and major outer membrane protein (MOMP). Methods A total of 19...
3 CitationsSource
#1Ahmad Aziz (UiTM: Universiti Teknologi MARA)H-Index: 10
#2Nor Hadiani Ismail (UiTM: Universiti Teknologi MARA)H-Index: 27
Last. Khalijah Awang (UM: University of Malaya)H-Index: 29
view all 8 authors...
A phytochemical investigation of the stem barks of the Malaysian Croton oblongus Burm.f. (Syn. Croton laevifolius Blume) (Euphorbiaceae) yielded seven previously undescribed ent-neo-clerodane diterpenoids, laevifins A - G (1, 2, 4-8) and the known crovatin (3). Structures were established by a combination of spectroscopic methods including HRESIMS, NMR spectroscopy and X-ray crystallography. The absolute configuration of crovatin and laevifins A-G was established by comparison of experimental EC...
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