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Mary Patricia Nowalk
University of Pittsburgh
VirologyVaccinationInfluenza vaccineFamily medicineMedicine
214Publications
36H-index
5,364Citations
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Publications 214
Newest
#1Krissy K. Moehling (University of Pittsburgh)H-Index: 11
#2Richard K. Zimmerman (University of Pittsburgh)H-Index: 37
Last. Brendan Flannery (CDC: Centers for Disease Control and Prevention)H-Index: 37
view all 11 authors...
Abstract Background Current influenza vaccine effectiveness (VE) improvement efforts focus on minimizing egg adaptation mutations during manufacture. This study compared immune response of two FDA-approved quadrivalent inactivated influenza vaccines in an unblinded randomized controlled trial. Methods Participants were 144 community dwelling, healthy children/adolescents aged 4–20 years, randomized 1:1 in blocks of 4 to a vaccine grown in cell culture (ccIIV4 [Flucelvax®]; n = 85); or in egg med...
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#1Sara S Kim (ORISE: Oak Ridge Institute for Science and Education)H-Index: 1
#2Brendan Flannery (CDC: Centers for Disease Control and Prevention)H-Index: 37
Last. Edward A. BelongiaH-Index: 57
view all 14 authors...
BACKGROUND We compared effects of prior vaccination and added or lost protection from current season vaccination among those previously vaccinated. METHODS Our analysis included data from the US Flu VE Network among participants ≥9 years old with acute respiratory illness from 2012-13 through 2017-18. Vaccine protection was estimated using multivariate logistic regression with an interaction term for effect of prior season vaccination on current season vaccine effectiveness. Models were adjusted...
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#1Richard K. Zimmerman (University of Pittsburgh)H-Index: 37
#2Mary Patricia Nowalk (University of Pittsburgh)H-Index: 36
Last. Goundappa K. Balasubramani (University of Pittsburgh)H-Index: 33
view all 7 authors...
Background: The introduction and rapid transmission of SARS CoV2 in the United States resulted in implementation of methods to assess, mitigate and contain the resulting COVID-19 disease based on limited knowledge. Screening for testing has been based on symptoms typically observed in inpatients, yet outpatient symptom complexes may differ. Methods: Classification and regression trees (CART) recursive partitioning created a decision tree classifying enrollees into laboratory-confirmed cases and ...
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#1Emily R Smith (CDC: Centers for Disease Control and Prevention)
#2Alicia M. Fry (CDC: Centers for Disease Control and Prevention)H-Index: 58
Last. Richard K. Zimmerman (University of Pittsburgh)H-Index: 37
view all 16 authors...
BACKGROUND: Improving appropriate antibiotic use is crucial for combating antibiotic resistance and unnecessary adverse drug reactions. Acute respiratory illness (ARI) commonly causes outpatient visits and accounts for ~41% of antibiotics used in the United States (U.S.). We examined the influence of influenza vaccination on reducing antibiotic prescriptions among outpatients with ARI. METHODS: We enrolled outpatients aged >/=6 months with ARI from 50-60 U.S. clinics during five winters (2013-20...
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#1Goundappa K. Balasubramani (University of Pittsburgh)H-Index: 33
#2Mary Patricia Nowalk (University of Pittsburgh)H-Index: 36
Last. Manjusha Gaglani (A&M: Texas A&M University)H-Index: 27
view all 13 authors...
BACKGROUND: Influenza vaccination is recommended for all US residents aged >/=6 months. Vaccine effectiveness (VE) varies by age, circulating influenza strains, and the presence of high-risk medical conditions. We examined site-specific VE in the US Influenza VE Network, which evaluates annual influenza VE at ambulatory clinics in geographically diverse sites. METHODS: Analyses were conducted on 27 180 outpatients >/=6 months old presenting with an acute respiratory infection (ARI) with cough of...
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#1John F. Alcorn (University of Pittsburgh)H-Index: 30
#2Raghunandan Avula (University of Pittsburgh)H-Index: 2
Last. Jennifer P. Nagg (University of Pittsburgh)H-Index: 1
view all 14 authors...
The human immune response to inactivated influenza vaccine is dynamic and impacted by age and preexisting immunity. Our goal was to identify postvaccination transcriptomic changes in peripheral blo...
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#1Angela R. Wateska (University of Pittsburgh)H-Index: 16
#2Mary Patricia Nowalk (University of Pittsburgh)H-Index: 36
Last. Kenneth J. Smith (University of Pittsburgh)H-Index: 30
view all 7 authors...
Introduction Recommending both the conjugate and polysaccharide pneumococcal vaccines to all U.S. seniors may have little public health impact and be economically unreasonable. Public health impact and cost-effectiveness of using both vaccines in all adults aged ≥65 years were estimated compared with an alternative strategy (omitting pneumococcal conjugate vaccine in the nonimmunocompromised) and with the newly revised recommendation (giving or omitting conjugate vaccine based on patient–physici...
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#1Angela R. Wateska (University of Pittsburgh)H-Index: 16
#2Mary Patricia Nowalk (University of Pittsburgh)H-Index: 36
Last. Kenneth J. Smith (University of Pittsburgh)H-Index: 30
view all 7 authors...
BACKGROUND/OBJECTIVES: Recently revised vaccination recommendations for US adults, aged 65 years and older, include both 23-valent pneumococcal polysaccharide vaccine (PPSV23) and 13-valent pneumococcal conjugate vaccine (PCV13), with PCV13 now recommended for immunocompetent older people based on shared decision making. The public health impact and cost-effectiveness of this recommendation or of pneumococcal vaccine uptake improvement interventions are unclear. DESIGN: Markov decision analysis....
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During the 2019-20 influenza season, influenza-like illness (ILI)* activity first exceeded the national baseline during the week ending November 9, 2019, signaling the earliest start to the influenza season since the 2009 influenza A(H1N1) pandemic. Activity remains elevated as of mid-February 2020. In the United States, annual vaccination against seasonal influenza is recommended for all persons aged >/=6 months (1). During each influenza season, CDC estimates seasonal influenza vaccine effecti...
4 CitationsSource
#1Manjusha Gaglani (A&M: Texas A&M University)H-Index: 27
#2Anupama Vasudevan (A&M: Texas A&M University)H-Index: 2
Last. Lisa A. Jackson (KP: Kaiser Permanente)H-Index: 66
view all 18 authors...
BACKGROUND: Since 2013, quadrivalent influenza vaccines containing two B viruses gradually replaced trivalent vaccines in the United States. We compared vaccine effectiveness of quadrivalent to trivalent inactivated vaccines (IIV4 to IIV3) against illness due to influenza B during the transition when IIV4 use increased rapidly. METHODS: The US Influenza Vaccine Effectiveness (Flu VE) Network analyzed 25,019 of 42,600 outpatients aged >/=6 months enrolled within 7 days of illness-onset during six...
3 CitationsSource
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