Victor M. Bolanos-Garcia
Oxford Brookes University
ChemistryKinetochoreBiochemistryBiologyCell biology
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Publications 84
#1Natalie L. Curtis (Oxford Brookes University)H-Index: 1
#2Gian Filippo Ruda (SGC: Structural Genomics Consortium)H-Index: 8
Last. Victor M. Bolanos-Garcia (Oxford Brookes University)H-Index: 23
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The mitotic spindle assembly checkpoint (SAC) is an intricate cell signaling system that ensures the high fidelity and timely segregation of chromosomes during cell division. Mistakes in this proce...
#1Andrada TomoniH-Index: 1
#2Jonathan LeesH-Index: 1
Last. Agatha BastidaH-Index: 20
view all 5 authors...
1 CitationsSource
Last. Victor M. Bolanos-GarciaH-Index: 23
view all 9 authors...
Breast cancer is the most commonly occurring cancer in women worldwide and the second most common cancer overall. The development of new therapies to treat this devastating malignancy is needed urgently. Nanoparticles are one class of nanomaterial with multiple applications in medicine, ranging from their use as drug delivery systems and the promotion of changes in cell morphology to the control of gene transcription. Nanoparticles made of the natural polymer chitosan are easy to produce, have a...
#1Sandra G. ZárateH-Index: 2
#2Paula MoralesH-Index: 11
Last. Agatha BastidaH-Index: 20
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Multidrug efflux systems play a prominent role in medicine, as they are important contributors to bacterial antibiotic resistance. NorA is an efflux pump transporter from the major facilitator superfamily that expels numerous drug compounds across the inner membrane of Staphylococcus aureus (S. aureus). The design of novel inhibitors to combat drug efflux could offer new opportunities to avoid the problem of antibiotic resistance. In this study, we performed molecular modeling studies in an effo...
In the present chapter we discuss the essential roles of the human E3 ubiquitin ligase Anaphase Promoting Complex/Cyclosome (APC/C) in mitosis as well as the emerging evidence of important APC/C roles in cellular processes beyond cell division control such as regulation of genomic integrity and cell differentiation of the nervous system. We consider the potential incipient role of APC/C dysregulation in the pathophysiology of the neurological disorder Alzheimer’s disease (AD). We also discuss ho...
#1Fernando Rodríguez (University of Chile)H-Index: 1
#2Carla Vallejos (University of Chile)H-Index: 1
Last. Mariana Aracena (UC: Pontifical Catholic University of Chile)H-Index: 5
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We report the case of a 3-year-old girl, who is the third child of nonconsanguineous parents, with short stature, hypertrophic cardiomyopathy, and mild dysmorphic features; all suggestive of Noonan syndrome. In addition, the patient presents with feeding difficulties, deep palmar and plantar creases, sparse hair, and delayed psychomotor and language development, all characteristics frequently observed in cardiofaciocutaneous syndrome. Molecular analysis of the Ras/ MAPK pathway genes using high-...
1 CitationsSource
Last. Agatha BastidaH-Index: 20
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#1Guillaume Combes (Laval University)H-Index: 3
#2Helena Barysz (Edin.: University of Edinburgh)H-Index: 3
Last. Sabine Elowe (Laval University)H-Index: 17
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Summary Monopolar spindle 1 (Mps1) is a conserved apical kinase in the spindle assembly checkpoint (SAC) that ensures accurate segregation of chromosomes during mitosis. Mps1 undergoes extensive auto- and transphosphorylation, but the regulatory and functional consequences of these modifications remain unclear. Recent findings highlight the importance of intermolecular interactions between the N-terminal extension (NTE) of Mps1 and the Hec1 subunit of the NDC80 complex, which control Mps1 locali...
9 CitationsSource
#1Maria Kapanidou (Oxford Brookes University)H-Index: 3
#2Natalie L. Curtis (Oxford Brookes University)H-Index: 1
Last. Victor M. Bolanos-Garcia (Oxford Brookes University)H-Index: 23
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Cell-division cycle protein 20 homologue (Cdc20) has important functions in chromosome segregation and mitotic exit. Cdc20 is the target of the spindle assembly checkpoint (SAC) and a key cofactor of the anaphase-promoting complex or cyclosome (APC/C) E3 ubiquitin ligase, thus regulating APC/C ubiquitin activity on specific substrates for their subsequent degradation by the proteasome. Here we discuss the roles of Cdc20 in SAC signalling and mitotic exit, describe how the integration of traditio...
20 CitationsSource
Mistakes in the process of cell division can lead to the loss, gain or rearrangement of chromosomes. Significant chromosomal abnormalities are usually lethal to the cells and cause spontaneous miscarriages. However, in some cases, defects in the spindle assembly checkpoint lead to severe diseases, such as cancer and birth and development defects, including Down’s syndrome. The timely and accurate control of chromosome segregation in mitosis relies on the spindle assembly checkpoint (SAC), an evo...