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Asghar Ghasemi
Shahid Beheshti University of Medical Sciences and Health Services
EndocrinologyPopulationNitric oxideDiabetes mellitusMedicine
193Publications
21H-index
2,265Citations
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Publications 202
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#1Nasibeh Yousefzadeh (Shahid Beheshti University of Medical Sciences and Health Services)
#2Sajad Jeddi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 11
Last. Asghar Ghasemi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 21
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BACKGROUND AND OBJECTIVE: All three isoforms of nitric oxide (NO) synthase (NOS) are targets for thyroid hormones in cardiovascular system. The aim of this study was to assess effects of hypoand hyperthyroidism on inducible (iNOS), endothelial (eNOS), and neural (nNOS) NOS levels in aorta and heart tissues of male rats. METHODS: Rats were divided into control, hypothyroid, and hyperthyroid groups; hypo- and hyperthyroidism were induced by adding propylthiouracil (500 mg/L) and L-thyroxine (12 mg...
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Decreased circulating levels of hydrogen sulfide (H2S) are associated with higher mortality following myocardial ischemia. This study aimed at determining the long-term dose-dependent effects of sodium hydrosulfide (NaSH) administration on myocardial ischemia-reperfusion (IR) injury. Male rats were divided into control and NaSH groups that were treated for 9 weeks with daily intraperitoneal injections of normal saline or NaSH (0.28, 0.56, 1.6, 2.8, and 5.6 mg/kg), respectively. At the end of the...
1 CitationsSource
#1Zahra Bahadoran (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 18
#2Parvin Mirmiran (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 44
Last. Asghar Ghasemi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 21
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Nitric oxide (NO) contributes to carbohydrate metabolism and decreased NO bioavailability is involved in the development of type 2 diabetes mellitus (T2DM). NO donors may improve insulin signaling and glucose homeostasis in T2DM and insulin resistance (IR), suggesting the potential clinical importance of NO-based interventions. In this review, site-specific roles of the NO synthase (NOS)–NO pathway in carbohydrate metabolism are discussed. In addition, the metabolic effects of physiological low ...
2 CitationsSource
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#1Zahra Bahadoran (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 18
#2Mattias Carlström (KI: Karolinska Institutet)H-Index: 23
Last. Asghar Ghasemi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 21
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Nitric oxide (NO), a highly reactive gasotransmitter, is critical for a number of cellular processes and has multiple biological functions. Due to its limited lifetime and diffusion distance, NO has been mainly believed to act in autocrine/paracrine fashion. The increasingly recognized effects of pharmacologically delivered and endogenous NO at a distant site have changed the conventional wisdom and introduced NO as an endocrine signalling molecule. The notion is greatly supported by the detecti...
1 CitationsSource
Transient congenital hypothyroidism (TCH) has long-lasting consequences on the cardiovascular system during adulthood. The aim of this study was to determine whether nitric oxide (NO) and NO-producing enzymes are involved in impaired cardiac function as well as decreased tolerance to ischemia-reperfusion (IR) injury in adult male rats with TCH. Pregnant rats were divided into control and hypothyroid groups. Male offspring rats were categorized in control and hypothyroid (TCH) groups at week 16. ...
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#1Nasibeh Yousefzadeh (Shahid Beheshti University of Medical Sciences and Health Services)
Last. Asghar GhasemiH-Index: 21
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Osteoporosis affects about 200 million people worldwide and is a silent disease until a fracture occurs. Management of osteoporosis is still a challenge that warrants further studies for establishing new prevention strategies and more effective treatment modalities. For this purpose, animal models of osteoporosis are appropriate tools, of which the ovariectomized rat model is the most commonly used. The aim of this study is to provide a 4-step guideline for inducing a rat model of osteoporosis b...
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#1Fatemeh Mohammadi (KMU: Kerman Medical University)H-Index: 1
#2Meysam Ahmadi-Zeidabadi (KMU: Kerman Medical University)H-Index: 2
Last. Mohammad Shabani (KMU: Kerman Medical University)H-Index: 18
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Aim: Empathy is defined as the capability to comprehend and simulate the feelings of others. Though it has been considered as a human feature, recent studies have demonstrated empathy-like behaviors in other animals including rats. The objective of the current study was to evaluate the role of nitric oxide system in cognition and nociception changes following observation of cagemates in pain.Material and methods: Adult male Wistar rats were used (n = 8 for each group). One sibling received forma...
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#1Zahra Bahadoran (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 18
#2Parvin Mirmiran (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 44
Last. Asghar Ghasemi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 21
view all 4 authors...
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