Maria Camilla Bergonzi
University of Florence
What is this?
Publications 124
#1Anna Rita BiliaH-Index: 36
#2Vieri PiazziniH-Index: 7
Last. Maria Camilla BergonziH-Index: 22
view all 3 authors...
Natural products are fascinating molecules in drug discovery for their exciting structure variability and for their interaction with various biological targets, which represent the best approach to develop successful medications for many diseases. The scarce water solubility, low lipophilicity and inappropriate molecular size of many natural compounds, which undergo structural instability in biological milieu, rapid clearance and high metabolic rate, have severely limited their use in clinic. Na...
#1Vieri Piazzini (UniFI: University of Florence)H-Index: 7
#2Elisa Landucci (UniFI: University of Florence)H-Index: 14
Last. Maria Camilla Bergonzi (UniFI: University of Florence)H-Index: 22
view all 7 authors...
Abstract Aripiprazole (ARP) is an antipsychotic drug approved for the treatment of schizophrenia. It is poorly water-soluble and undergoes extensive hepatic metabolism and P-gp efflux, which lead to poor bioavailability and increased dose-related side effects. This study focuses on the preparation of mixed micelles (MM) to enhance the aqueous solubility, oral bioavailability, and blood–brain barrier permeation of ARP. For this purpose, Soluplus and D-α-tocopheryl polyethylene glycol 1000 succina...
#1Anna Rita Bilia (UniFI: University of Florence)H-Index: 36
#2Maria Camilla Bergonzi (UniFI: University of Florence)H-Index: 22
Abstract Ginseng products on the market show high variability in their composition and overall quality. This becomes a challenge for both consumers and health care professionals who are in search of high-quality, reliable ginseng products that have a proven safety and efficacy profile. The botanical extract standardization is of crucial importance in this context as it determines the reproducibility of the quality of the product which is essential for the evaluation of effectiveness and safety. ...
The permeability of saponins and sapogenins from fenugreek and quinoa extracts, as well as dioscin and diosgenin, was evaluated by the parallel artificial membrane permeability assay (PAMPA). The effect of the digestion process on permeability was determined, with previous development of a gastrointestinal process coupled to PAMPA. Saponins from both seeds displayed a moderate-to-poor permeability (>1 × 10–6 cm/s), although the digestion enhanced their permeability values in the order of 10–5 cm...
#1Anna Rita Bilia (UniFI: University of Florence)H-Index: 36
view all 4 authors...
The therapeutic potential of artemisinin (ART) and its derivatives (ARTs) is not limited to malaria but has been recently expanded to other infections with protozoans, trematodes, or viruses as well as to cancer. Due to their limited poor water and oil solubility, rapid degradation by the liver, and short half-life, they have a low bioavailability after oral administration. Consequently, there is a pressing necessity to formulate new ART preparations to raise its bioavailability and efficacy. Na...
#1Giulia VantiH-Index: 1
#2Daniele BaniH-Index: 42
Last. Anna Rita BiliaH-Index: 36
view all 5 authors...
Escin is a natural saponin, clinically used for the anti-edematous and anti-inflammatory effects. The aim of the study was to explore the possibility of converting escin into vesicle bilayer-forming component. The hyaluronidase inhibition activity of escin was evaluated after its formulation in escinosomes. Berberine chloride, a natural quaternary isoquinoline alkaloid isolated from several medicinal plants that is traditionally used for various skin conditions was loaded in the vesicles. The de...
#2Elisa LanducciH-Index: 14
Last. Cristina NativiH-Index: 23
view all 12 authors...
The transient receptor potential akyrin type-1 (TRPA1) is a non-selective cation channel playing a pivotal role in pain sensation and neurogenic inflammation. TRPA1 channels expressed in the central nervous system (CNS) have a critical role in the modulation of cortical spreading depression (CSD), which is a key pathophysiological basis of migraine pain. ADM_09 is a recently developed lipoic acid-based TRPA1 antagonist that is able to revert oxaliplatin-induced neuropathic pain and inflammatory ...
#1Vieri PiazziniH-Index: 7
#2Marzia VasarriH-Index: 1
Last. Maria Camilla BergonziH-Index: 22
view all 7 authors...
Posidonia oceanica (L.) Delile is a marine plant endemic of Mediterranean Sea endowed with interesting bioactivities. The hydroalcholic extract of P. oceanica leaves (POE), rich in polyphenols and carbohydrates, has been shown to inhibit human cancer cell migration. Neuroblastoma is a common childhood extracranial solid tumor with high rate of invasiveness. Novel therapeutics loaded into nanocarriers may be used to target the migratory and metastatic ability of neuroblastoma. Our goal was to imp...
#1Laura Risaliti (UniFI: University of Florence)H-Index: 2
#2Gabriella Pini (UniFI: University of Florence)H-Index: 10
Last. Anna Rita Bilia (UniFI: University of Florence)H-Index: 36
view all 8 authors...
#1Giulia Vanti (UniFI: University of Florence)H-Index: 1
#2V Dourdouni (A.U.Th.: Aristotle University of Thessaloniki)
Last. Anna Rita Bilia (UniFI: University of Florence)H-Index: 36
view all 11 authors...