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Marcel Ottens
Delft University of Technology
Analytical chemistryAdsorptionOrganic chemistryChemistryChromatography
98Publications
21H-index
1,787Citations
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Publications 93
Newest
#1D.C. Gernat (TU Delft: Delft University of Technology)H-Index: 1
#2R. Rozenbroek (TU Delft: Delft University of Technology)
Last. Marcel Ottens (TU Delft: Delft University of Technology)H-Index: 21
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#1D.C. Gernat (TU Delft: Delft University of Technology)H-Index: 1
#2M.M. Penning (TU Delft: Delft University of Technology)
Last. Marcel Ottens (TU Delft: Delft University of Technology)H-Index: 21
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Abstract A common sensory deficiency of alcohol-free beers (AFB) is caused by the presence of worty aldehydes. The aim of this study was to develop and proof the concept of a selective adsorption step, facilitating the removal of aldehydes from AFB. Therefore, the performance of 21 adsorbents (amine-functionalized polymers, hydrophobic resins and zeolites) was tested in wort. Among the studied adsorbents, hydrophobic ZSM-5 type zeolites (CBV28014, HiSiv3000 and ZSM-5 P-360) showed the best selec...
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#1Ana C. A. RoqueH-Index: 22
#2Ana Sofia PinaH-Index: 8
Last. Marcel Ottens (TU Delft: Delft University of Technology)H-Index: 21
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While packed bed chromatography, known as conventional chromatography, has been serving the biopharmaceutical industry for decades as the bioseparation method of choice, alternative approaches are likely to take an increasing leading role in the next few years. The high number of new biological drugs under development, and the need to make biopharmaceuticals widely accessible, has been driving the academia and industry in the quest of anything but conventional chromatography approaches. In this ...
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#1Hoon Suk Rho (UM: Maastricht University)H-Index: 1
#1Hoon Suk RhoH-Index: 7
Last. Han Gardeniers (MESA+ Institute for Nanotechnology)H-Index: 23
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A microfluidic protein aggregation device (microPAD) that allows the user to perform a series of protein incubations with various concentrations of two reagents is demonstrated. The microfluidic device consists of 64 incubation chambers to perform individual incubations of the protein at 64 specific conditions. Parallel processes of metering reagents, stepwise concentration gradient generation, and mixing are achieved simultaneously by pneumatic valves. Fibrillation of bovine insulin was selecte...
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#1Mónica Moreno-González (TU Delft: Delft University of Technology)H-Index: 1
#2Vasupradha Girish (TU Delft: Delft University of Technology)
Last. Marcel Ottens (TU Delft: Delft University of Technology)H-Index: 21
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Abstract Sinapic acid is a potential valuable compound to be recovered from rapeseed meal extracts as it processes antioxidant and antimicrobial properties. However, the concentration of this compound might be low and the presence of other low value compounds could complicate its downstream processing. Adsorption is an alternative technique that might allow selective recovery of this compound. This work was focused on establishing the foundation of an industrial process design to recover sinapic...
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#1D.C. Gernat (TU Delft: Delft University of Technology)H-Index: 1
#2Eric BrouwerH-Index: 2
Last. Marcel Ottens (TU Delft: Delft University of Technology)H-Index: 21
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Although present in concentrations in microgrammes per litre level, aldehydes, in particular those derived from Strecker degradation, are known to majorly contribute to the undesired wort flavour of alcohol-free beers. In order to improve currently available products, one needs to understand the underlying cause for the over-prevalence and identify leverage points and methods to selectively reduce the aldehydes in alcohol-free beers. This work gives a short overview on relevant flavour-active wo...
1 CitationsSource
#1Silvia M. Pirrung (TU Delft: Delft University of Technology)H-Index: 2
#2Carmen Berends (TU Delft: Delft University of Technology)H-Index: 1
Last. Marcel Ottens (TU Delft: Delft University of Technology)H-Index: 21
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Abstract Finding the best purification process is a challenging task. Recently, mechanistic models that can accelerate the development of chromatographic unit operations, the most important purification units, became widely available. In previous work, several chromatographic models have been linked together to simulate and optimize integrated processes. However, considering only chromatographic steps may lead to a suboptimal process. Consequently, the aim of this study was to include models for...
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#1Bianca Consorti Bussamra (TU Delft: Delft University of Technology)H-Index: 2
#2Joana Castro Gomes (TU Delft: Delft University of Technology)H-Index: 2
Last. Marcel Ottens (TU Delft: Delft University of Technology)H-Index: 21
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Abstract Aqueous two-phase systems (ATPS) can be applied to enzymatic reactions that are affected by product inhibition. In the biorefinery context, sugars inhibit the cellulolytic enzymes in charge of converting the biomass. Here, we present a strategy to select an ATPS (formed by polymer and salt) that can separate sugar and enzymes. This automated and miniaturized method is able to determine phase diagrams and partition coefficients of solutes in these. Tailored approaches to quantify the sol...
1 CitationsSource
#1Nicolai Kallscheuer (Forschungszentrum Jülich)H-Index: 12
#2Regina Menezes (NOVA: Universidade Nova de Lisboa)H-Index: 18
Last. Jan Marienhagen (Forschungszentrum Jülich)H-Index: 24
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Edible berries are considered to be among nature9s treasure chests as they contain a large number of (poly)phenols with potentially health-promoting properties. However, as berries contain complex (poly)phenol mixtures, it is challenging to associate any interesting pharmacological activity with a single compound. Thus, identification of pharmacologically interesting phenols requires systematic analyses of berry extracts. Here, raspberry (Rubus idaeus, var. Prestige) extracts were systematically...
3 CitationsSource
#1Miao Yu (TU Delft: Delft University of Technology)H-Index: 2
#2Tiago Castanheira Silva (TU Delft: Delft University of Technology)H-Index: 1
Last. Marcel Ottens (TU Delft: Delft University of Technology)H-Index: 21
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Abstract In this study, we developed a microfluidics method, using a so-called H-cell microfluidics device, for the determination of protein diffusion coefficients at different concentrations, pHs, ionic strengths, and solvent viscosities. Protein transfer takes place in the H-cell channels between two laminarly flowing streams with each containing a different initial protein concentration. The protein diffusion coefficients are calculated based on the measured protein mass transfer, the channel...
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