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Isabel Garcia-Perez
Imperial College London
EndocrinologyMetabolomicsPopulationMedicineBiology
49Publications
14H-index
741Citations
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Publications 50
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#1Jessica R. Allegretti (Brigham and Women's Hospital)H-Index: 14
#2Zain KassamH-Index: 16
Last. Christopher C. Thompson (Brigham and Women's Hospital)H-Index: 82
view all 17 authors...
Abstract Background & Aims Studies in mice have shown that the intestinal microbiota can contribute to obesity via the anorexigenic gut hormone glucagon-like peptide 1 (GLP1) and bile acids, which affect lipid metabolism. We performed a randomized, placebo-controlled pilot study of the effects of fecal microbiota transplantation (FMT) in obese, metabolically uncompromised patients. Methods We performed a double-blind study of 22 obese patients (body mass index [BMI] ≥ 35kg/m 2 ) without a diagno...
1 CitationsSource
#2Isabel Garcia-Perez (Imperial College London)H-Index: 14
Last. Antonia GarcíaH-Index: 29
view all 6 authors...
Abstract In the nutrition field, there is a lack of understanding about the impact that dietary chiral composition may have on health, especially regarding cooked meals. Chiral amino acids (AAs) are naturally present in food and their proportion may vary quite a lot. Besides, the D-amino acids (D-AAs) are present in very low concentration compared to L-AAs, so very sensitive methods are required for their accurate quantitation. Moreover, some of them have been described as indicators of quality ...
Source
#1Ciara O'Donovan (UCC: University College Cork)H-Index: 3
#2Sharon M. MadiganH-Index: 1
Last. Paul D. Cotter (UCC: University College Cork)H-Index: 64
view all 6 authors...
Abstract Objectives The gut microbiome has begun to be characterised in athlete groups, albeit, to date, only across a subset of sports. This study aimed to determine if the gut microbiome and metabolome differed across sports classification groups (SCGs) among elite Irish athletes, many of whom were participating in the 2016 Summer Olympics. Methods Faecal and urine samples were collected from 37 international level athletes. Faecal samples were prepared for shotgun metagenomic sequencing and f...
1 CitationsSource
#1Parag Kundu (CAS: Chinese Academy of Sciences)H-Index: 6
#2Hae Ung Lee (NTU: Nanyang Technological University)H-Index: 2
Last. Sven Pettersson (KI: Karolinska Institutet)H-Index: 46
view all 14 authors...
The gut microbiota evolves as the host ages, yet the effects of these microbial changes on host physiology and energy homeostasis are poorly understood. To investigate these potential effects, we transplanted the gut microbiota of old or young mice into young germ-free recipient mice. Both groups showed similar weight gain and skeletal muscle mass, but germ-free mice receiving a gut microbiota transplant from old donor mice unexpectedly showed increased neurogenesis in the hippocampus of the bra...
6 CitationsSource
#1Thomas Wilson (Aberystwyth University)H-Index: 5
#2Isabel Garcia-Perez (Imperial College London)H-Index: 14
Last. John Draper (Aberystwyth University)H-Index: 30
view all 12 authors...
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#1Edward S. Chambers (Imperial College London)H-Index: 14
#2Claire S Byrne (Imperial College London)H-Index: 4
Last. Gary Frost (Imperial College London)H-Index: 11
view all 20 authors...
Objective To investigate the underlying mechanisms behind changes in glucose homeostasis with delivery of propionate to the human colon by comprehensive and coordinated analysis of gut bacterial composition, plasma metabolome and immune responses. Design Twelve non-diabetic adults with overweight and obesity received 20 g/day of inulin-propionate ester (IPE), designed to selectively deliver propionate to the colon, a high-fermentable fibre control (inulin) and a low-fermentable fibre control (ce...
7 CitationsSource
#1Shawon Lahiri (KI: Karolinska Institutet)H-Index: 2
#2Hye Jin Kim (NTU: Nanyang Technological University)H-Index: 2
Last. Sven Pettersson (KI: Karolinska Institutet)H-Index: 46
view all 19 authors...
The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free mice that had a gut microbiota. Compared to pathogen-free mouse skeletal muscle, germ-free mouse skeletal muscle showed atrophy, decreased expression of insulin-like growth factor 1, and reduced transcription of genes associated with skeletal ...
2 CitationsSource
#1Anna Ek (KI: Karolinska Institutet)H-Index: 7
#2Christine Delisle Nyström (KI: Karolinska Institutet)H-Index: 7
Last. Paulina Nowicka (KI: Karolinska Institutet)H-Index: 17
view all 14 authors...
Childhood overweight and obesity is a serious public health issue with an increase being observed in preschool-aged children. Treating childhood obesity is difficult and few countries use standardized treatments. Therefore, there is a need to find effective approaches that are feasible for both health care providers and families. Thus, the overall aim of this study is to assess the acceptance and effectiveness of a parent support program (the More and Less, ML) for the management of overweight a...
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#1Amanda J. Lloyd (Aberystwyth University)H-Index: 14
#2N. D. WillisH-Index: 5
Last. John Draper (Aberystwyth University)H-Index: 30
view all 11 authors...
Source
#1Amanda J. Lloyd (Aberystwyth University)H-Index: 14
#2N. D. Willis (Newcastle University)H-Index: 5
Last. John Draper (Aberystwyth University)H-Index: 30
view all 11 authors...
Introduction Dietary exposure monitoring within populations is reliant on self-reported measures such as Food Frequency Questionnaires and diet diaries. These methods often contain inaccurate information due to participant misreporting, non-compliance and bias. Urinary metabolites derived from individual foods could provide additional objective indicators of dietary exposure. For biomarker approaches to have utility it is essential that they cover a wide-range of commonly consumed foods and the ...
1 CitationsSource
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