Peter Vollenweider
University of Lausanne
Publications 507
#1Ching-Ti Liu (BU: Boston University)H-Index: 35
#2Jordi Merino (Broad Institute)H-Index: 11
Last.Nabila Bouatia-Naji (Paris V: Paris Descartes University)H-Index: 12
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Type 2 diabetes (T2D) affects the health of millions of people worldwide. The identification of genetic determinants associated with changes in glycemia over time might illuminate biological features that precede the development of T2D. Here we conducted a genome-wide association study of longitudinal fasting glucose changes in up to 13,807 non-diabetic individuals of European descent from nine cohorts. Fasting glucose change over time was defined as the slope of the line defined by multiple fas...
#1Tuomas O. Kilpelaeinen (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 33
#2Amy R. Bentley (NIH: National Institutes of Health)H-Index: 16
Last.Ruth Loos (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 111
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Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...
6 CitationsSource
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint ana...
#1Vladeta Ajdacic-Gross (UZH: University of Zurich)H-Index: 30
#2Margot Mutsch (UZH: University of Zurich)H-Index: 12
Last.Martin Preisig (UNIL: University of Lausanne)H-Index: 48
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Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables.
#1Nazanin Abolhassani (UNIL: University of Lausanne)H-Index: 2
#2José Haba-Rubio (UNIL: University of Lausanne)H-Index: 22
Last.Pedro Marques-Vidal (UNIL: University of Lausanne)H-Index: 57
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Abstract Objective The aim of this study was to assess the trends and determinants of sleeping pill consumption in the general population. Methods This was a prospective study that included 4329 participants (2379 women, 51.9 ± 10.4 years) living in the city of Lausanne, Switzerland, followed up for an average of 10.9 years. Benzodiazepines and benzodiazepine receptor agonists were considered as sleeping pills. Results The prevalence (95% confidence interval [CI]) of sleeping pills use was 8.0% ...
1 CitationsSource
Handedness, a consistent asymmetry in skill or use of the hands, has been studied extensively because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and 32 studies from the International Handedness Consortium, we conducted the world9s largest genome-wide association study of handedness (1,534,836 right-handed, 194,198 (11.0%) left-handed and 37,637 (2.1%) ambidextrous individuals). We fou...